286 research outputs found
Signature of frustrated moments in quantum critical CePdNiAl
CePdAl with Ce moments forming a distorted kagom\'e network is one of
the scarce materials exhibiting Kondo physics and magnetic frustration
simultaneously. As a result, antiferromagnetic (AF) order setting in at
~K encompasses only two thirds of the Ce moments. We
report measurements of the specific heat, , and the magnetic Gr\"uneisen
parameter, , on single crystals of CePdNiAl with
at temperatures down to 0.05~K and magnetic fields up to
~T. Field-induced quantum criticality for various concentrations is observed
with the critical field decreasing to zero at . Remarkably,
two-dimensional (2D) AF quantum criticality of Hertz-Millis-Moriya type arises
for and at the suppression of 3D magnetic order. Furthermore,
shows an additional contribution near ~T for all
concentrations which is ascribed to correlations of the frustrated one third of
Ce moments.Comment: 5+2 pages with 4+3 figure
Technologie als Quelle systemischer Transformationsprozesse: Implikationen fĂŒr die Theoriediskussion im Fach Internationale Beziehungen
'Obwohl Technologie viele Bereiche der internationalen Beziehungen/ internationalen politischen Ăkonomie entscheidend mitbeeinflusst, wird ihrer Rolle in den theoretischen Diskussionen nur wenig Aufmerksamkeit zuteil. Trotzdem sie fĂŒr zahlreiche systemtransformierende Prozesse (Globalisierung/ Transnationalisierung) mitverantwortlich zu machen ist, wird Technologie in der Regel als passives, exogenes und apolitisches Artefakt, das quasi von auĂen in das internationale System hineinwirkt, konzipiert. Stattdessen plĂ€diert der Beitrag dafĂŒr, Technologie in ihren mannigfaltigen Erscheinungsformen und Auswirkungen als einen endogenen, sprich, systemimmanenten und politisch relevanten Faktor zu begreifen, der auch fest im internationalen System verhaftet ist und dort wirkt, parallel dazu und in zunehmendem MaĂe aber erst auf globaler Ebene hinsichtlich seiner systemischen Auswirkungen effizienter beeinflusst und (re)reguliert werden kann. Im Vordergrund des Beitrags steht der Versuch aufzuzeigen, inwiefern Ergebnisse sozialwissenschaftlicher Technikforschung (Technikphilosophie, Techniksoziologie, Technikgeschichte) Theoriediskussionen der Internationalen Beziehungen substantiell bereichern könnten.' (Autorenreferat)'Although technology's increasingly importance in many areas of international relations/ international political economy, it still plays a minor role in theoretical discussions within International Relations/ International Political Economy. Even though, technology seems to be jointly responsible for major transformations of the international system (e.g. globalization, transnationalization), it is mostly conceptualized as a passive, exogenous and apolitical factor, affecting the international system from outside. Instead, the article argues that technology in its various manifestations and consequences should be understood as endogenous, influential and highly political factor, which is inherent to the international system. Furthermore the article suggests that, more and more, technology and its systemwide effects can only be (re)regulated at the global level. The article's main focus of attention becomes the attempt to point out, how the incorporation of technology-related discussion results of neighbour disciplines (e.g. philosophy of technology, sociology of technology, history of technology) can enrich the analytical strength of theories of International Relations.' (author's abstract
neuralnet: Training of neural networks
Artificial neural networks are applied in many situations. neuralnet is built to train multi-layer perceptrons in the context of regression analyses, i.e. to approximate functional relationships between covariates and response variables. Thus, neural networks are used as extensions of generalized linear models. neuralnet is a very flexible package. The backpropagation algorithm and three versions of resilient backpropagation are implemented and it provides a custom-choice of activation and error function. An arbitrary number of covariates and response variables as well as of hidden layers can theoretically be included
Comparison of the Accuracy of 2D and 3D Templating for Revision Total Hip Replacement
Introduction: Revision hip arthroplasty is a challenging surgical procedure, especially in
cases of advanced acetabular bone loss. Accurate preoperative planning can prevent complications
such as periprosthetic fractures or aseptic loosening. To date, the accuracy of three-dimensional
(3D) versus two-dimensional (2D) templating has been evaluated only in primary hip and knee
arthroplasty. Methods: We retrospectively investigated the accuracy of 3D personalized planning
of reinforcement cages (Burch Schneider) in 27 patients who underwent revision hip arthroplasty.
Personalized 3D modeling and positioning of the reinforcement cages were performed using computed tomography (CT) of the pelvis of each patient and 3D templates of the implant. To evaluate
accuracy, the sizes of the reinforcement cages planned in 2D and 3D were compared with the sizes of
the finally implanted cages. Factors that may potentially influence planning accuracy such as gender
and body mass index (BMI) were analyzed. Results: There was a significant difference (p = 0.003)
in the accuracy of correct size prediction between personalized 3D templating and 2D templating.
Personalized 3D templating predicted the exact size of the reinforcement cage in 96.3% of the patients,
while the exact size was predicted in only 55.6% by 2D templating. Regarding gender and BMI,
no statistically significant differences in planning accuracy either for 2D or 3D templating were
observed. Conclusion: Personalized 3D planning of revision hip arthroplasty using Burch Schneider
reinforcement cages leads to greater accuracy in the prediction of the required size of implants than
conventional 2D templating
CePdAl - a Kondo lattice with partial frustration
Magnetic frustration, which is well-defined in insulating systems with
localized magnetic moments, yields exotic ground states like spin ices, spin
glasses, or spin liquids. In metals magnetic frustration is less well defined
because of the incipient delocalization of magnetic moments by the interaction
with conduction electrons, viz., the Kondo effect. Hence, the Kondo effect and
magnetic frustration are antithetic phenomena. Here we present experimental
data of electrical resistivity, magnetization, specific heat and neutron
diffraction on CePdAl, which is one of the rare examples of a geometrically
frustrated Kondo lattice, demonstrating that the combination of Kondo effect
and magnetic frustration leads to an unusual ground state.Comment: 8 pages, 6 figure
Chemical freeze-out in heavy ion collisions at large baryon densities
We argue that the chemical freeze-out in heavy ion collisions at high baryon
density is not associated to a phase transition or rapid crossover. We employ
the linear nucleon-meson model with parameters fixed by the zero-temperature
properties of nuclear matter close to the liquid-gas quantum phase transition.
For the parameter region of interest this yields a reliable picture of the
thermodynamic and chiral properties at non-zero temperature. The chemical
freeze-out observed in low-energy experiments occurs when baryon densities fall
below a critical value of about 15 percent of nuclear density. This region in
the phase diagram is far away from any phase transition or rapid crossover.Comment: 8 pages, 11 figures, published versio
Retrospective Analysis of Treatment Pathways in Patients With BRAFV600E-mutant Metastatic Colorectal Carcinoma â MORSECRC
Background/aim: Metastatic colorectal cancer (mCRC) is a heterogeneous disease with distinct molecular subtypes. The BRAFV600E-mutation found in approximately 8-12% of mCRC patients is associated with poor prognosis. Guideline recommendations for this population are mostly based on small cohorts due to lack of clinical data. This retrospective analysis was designed to evaluate (approved) therapeutic approaches and algorithms in BRAFV600E-mutant mCRC prior to approval of the targeted combination encorafenib plus cetuximab in Germany, Austria, and Switzerland.
Patients and methods: Anonymized data from BRAFV600E-mutant mCRC patients were analyzed retrospectively regarding 1st-, 2nd- and 3rd-line treatment using descriptive statistics.
Results: Forty-two patients were eligible for analysis (mean age 62.1 years, 47.6% female). At initial diagnosis, 20 patients (47.6%) were documented with right-sided tumors. Most patients (81.0%) were tested for BRAF before 1st-line. Four patients (9.5%) showed high microsatellite instability (MSI-H). Based on 94 treatment lines, chemotherapy combined with targeted therapy (TT) was used mostly (61.7%), followed by chemotherapy alone (19.1%). Backbone therapies were most frequently FOLFOXIRI (27.7%), FOLFOX/CAPOX (22.3%), or FOLFIRI (20.2%). Anti-VEGF/VEGFR and anti-EGFR-treatments were used in 45.7% and 23.4% of patients, respectively. Across all treatment lines and types, the predominantly documented reason for discontinuation was lack of efficacy.
Conclusion: Combined chemotherapy+TT (anti-VEGF/VEGFR and anti-EGFR) played a predominant role in BRAFV600E-mutated mCRC treatment prior to approval of the targeted combination encorafenib plus cetuximab. Since lack of efficacy was the major reason for treatment discontinuation, newly approved therapies including encorafenib plus cetuximab and - for MSI-H tumors - pembrolizumab represent urgently needed options for future mCRC patients.
Keywords: Austria; Chemotherapy; Germany; Switzerland; disease characteristics; targeted therapy; treatment reality
The impact of sulfur hexafluoride (SFâ) sinks on age of air climatologies and trends
Mean age of air (AoA) is a common diagnostic for the strength of the stratospheric overturning circulation in both climate models and observations. AoA climatologies and AoA trends over the recent decades of model simulations and proxies derived from observations of long-lived tracers do not agree. Satellite observations show much older air than climate models, and while most models compute a clear decrease in AoA over the last decades, a 30-year time series from measurements shows a statistically nonsignificant positive trend in the Northern Hemisphere extratropical middle stratosphere. Measurement-based AoA derivations are often founded on observations of the trace gas sulfur hexafluoride (SF), a fairly long-lived gas with a near-linear increase in emissions during recent decades. However, SF has chemical sinks in the mesosphere that are not considered in most model studies. In this study, we explicitly compute the chemical SF sinks based on chemical processes in the global chemistry climate model EMAC (ECHAM/MESSy Atmospheric Chemistry). We show that good agreement between stratospheric AoA in EMAC and MIPAS (Michelson Interferometer for Passive Atmospheric Sounding) is reached through the inclusion of chemical SF sinks, as these sinks lead to a strong increase in the stratospheric AoA and, therefore, to a better agreement with MIPAS satellite observations. Remaining larger differences at high latitudes are addressed, and possible reasons for these differences are discussed. Subsequently, we demonstrate that the AoA trends are also strongly influenced by the chemical SF6 sinks. Under consideration of the SF sinks, the AoA trends over the recent decades reverse sign from negative to positive. We conduct sensitivity simulations which reveal that this sign reversal does not result from trends in the stratospheric circulation strength nor from changes in the strength of the SF sinks. We illustrate that even a constant SF destruction rate causes a positive trend in the derived AoA, as the amount of depleted SF scales with increasing SF abundance itself. In our simulations, this effect overcompensates for the impact of the accelerating stratospheric circulation which naturally decreases AoA. Although various sources of uncertainties cannot be quantified in detail in this study, our results suggest that the inclusion of SF depletion in models has the potential to reconcile the AoA trends of models and observations. We conclude the study with a first approach towards a correction to account for SF loss and deduce that a linear correction might be applicable to values of AoA of up to 4 years
New Element Organic Frameworks Based on Sn, Sb, and Bi, with Permanent Porosity and High Catalytic Activity
We present new element organic frameworks based on Sn, Sb and Bi atoms connected via organic linkers by element-carbon bonds. The open frameworks are characterized by specific surface areas (BET) of up to 445 mÂČ gâ»Âč and a good stability under ambient conditions resulting from a highly hydrophobic inner surface. They show good performance as heterogeneous catalysts in the cyanosylilation of benzaldehyde as a test reaction. Due to their catalytic activity, this class of materials might be able to replace common homogeneous element-organic and often highly toxic catalysts especially in the food industry
Carbon Nanotube Network Ambipolar Field-Effect Transistors with 10(8) On/Off Ratio
Polymer wrapping is a highly effective method of selecting semiconducting carbon nanotubes and dispersing them in solution. Semi-aligned semiconducting carbon nanotube networks are obtained by blade coating, an effective and scalable process. The field-effect transistor (FET) performance can be tuned by the choice of wrapping polymer, and the polymer concentration modifies the FET transport characteristics, leading to a record on/off ratio of 108
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