732 research outputs found

    Particle physics after the Higgs discovery: philosophical perspectives

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    The recent discovery at the LHC of a particle with properties matching those expected of the Higgs boson is a decisive event in the history of particle physics. The present special section combines three contributions that approach conceptual and methodological challenges related to this event and the current situation in particle physics from different angles. On

    Motivating Wittgenstein's Perspective on Mathematical Sentences as Norms

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    Reversible inhibition of mammalian tubulin assembly in vitro and effects in Saccharomyces cerevisiae D61.M by mitomycin C

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    Gaulden reported a novel and unexpected mitomycin C (MMC) effect, namely a pronounced retardation of very late prophase and loss of chromosome orientation in neuroblasts of the grasshopper Chortophaga viridifasciate. Because this effect may be due to interactions of MMC with non-DNA targets, MMC was tested for its interaction with porcine brain tubulin assembly in vitro and for the induction of chromosomal malsegregation in the diploid yeast Saccharomyces cerevisiae strain D61.M. A reversible dose-dependent inhibition of tubulin assembly was observed. Since no biological activation system was present in the incubation mixture this inhibition seems to result from an interaction of unactivated MMC with the assembly process. The possible chemical activation of MMC by reduction with 1, 4-dithioerythritol (DTE) was investigated by omission of this compound during isolation and polymerization of tubulin. The absence of DTE resulted in a strong reduction of the net tubulin assembly. Also under these conditions MMC led to a dose-dependent inhibition of the assembly, indicating that the effect of MMC on tubulin assembly is independent of a reductive chemical modification. In S.cerevisiae D61.M, MMC did not induce chromosome loss, but induced other genetic events (possibly mutations, deletions or mitotic recombination) as was detected by an increase of the total number and of the frequency of cycloheximide-resistant colonies. This effect could be observed with and without the addition of rat liver S9 as an exogenous activation syste

    Incommensurate antiferromagnetic fluctuations in the two-dimensional Hubbard model

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    Commensurate and incommensurate antiferromagnetic fluctuations in the two-dimensional repulsive t-t'-Hubbard model are investigated using functional renormalization group equations. For a sufficient deviation from half filling we establish the existence of local incommensurate order below a pseudocritical temperature T_{pc}. Fluctuations not accounted for in the mean field approximation are important--they lower T_{pc} by a factor \approx2.5.Comment: 7 pages, 8 figures, some changes due to referees' comments, equivalent to published versio

    Motivating Wittgenstein's Perspective on Mathematical Sentences as Norms

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