18 research outputs found
WALTER ROTHKEGEL (1874 – 1959) Begründer der Reichsbodenschätzung
Das Bodenschätzungsgesetz von 1934 geht im Wesentlichen auf die Initiativen von ROTHKEGEL und HERZOG zurück. Es ist ein Verdienst von W. ROTHKEGEL, dass er erstmalig und bisher einmalig eine einheitliche Bodenbonitierung und zugleich auch großmaßstäbige Boden-kartierung für Deutschland durchgesetzt und flächendeckend realisiert hat. W. ROTHKEGEL hat als Wegbereiter der Bodenschätzung auch deren Ausrichtung für die nichtsteuerliche Auswertung und Anwendung und damit die bodenkund-liche Zielstellung gesetzlich verankert. Die einheitliche Datenfülle der Boden-schätzung ist für die Umsetzung der Bodenschutzgesetze eine wesentliche Voraussetzung
RAD51C – a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC)
INTRODUCTION:
Head and neck squamous cell carcinomas (HNSSCs) are one of the leading causes of cancer-associated death worldwide. Although certain behavioral risk factors are well recognized as tumor promoting, there is very little known about the presence of predisposing germline mutations in HNSCC patients.
METHODS:
In this study, we analyzed 121 individuals with HNSCCs collected at our institution for germline alterations in the newly identified cancer susceptibility gene RAD51C.
RESULTS:
Sequencing of all exons and the adjacent introns revealed five distinct heterozygous sequence deviations in RAD51C in seven patients (5.8%). A female patient without any other risk factors carried a germline mutation that disrupted the canonical splice acceptor site of exon 5 (c.706-2A>G).
CONCLUSIONS:
As there are only a few publications in the literature identifying germline mutations in head and neck cancer patients, our results provide the first indication that paralogs of RAD51, recently described as mutated in breast and ovarian cancer patients, might also be candidates for genetic risk factors in sporadic squamous cell carcinomas of the head and neck
Toward Low-Temperature Dehydrogenation Catalysis: Isophorone Adsorbed on Pd(111)
Adsorbate geometry and reaction dynamics play essential roles in catalytic processes at surfaces. Here we present a theoretical and experimental study for a model functional organic/metal interface: isophorone (C9H14O) adsorbed on the Pd(111) surface. Density functional theory calculations with the Perdew-Burke-Ernzerhoff (PBE) functional including van der Waals (vdW) interactions, in combination with infrared spectroscopy and temperature-programmed desorption (TPD) experiments reveal the reaction pathway between the weakly chemisorbed reactant (C9H14O) and the strongly chemisorbed product (C9H10O), which occurs by the cleavage of four C-H bonds below 250 K. Analysis of the TPD spectrum is consistent with the relatively small magnitude of the activation barrier derived from PBE+vdW calculations, demonstrating the feasibility of low-temperature dehydrogenation
Toward Low-Temperature Dehydrogenation Catalysis: Isophorone Adsorbed on Pd(111)
Adsorbate geometry and reaction dynamics play essential
roles in
catalytic processes at surfaces. Here we present a theoretical and
experimental study for a model functional organic/metal interface:
isophorone (C<sub>9</sub>H<sub>14</sub>O) adsorbed on the Pd(111)
surface. Density functional theory calculations with the Perdew–Burke–Ernzerhoff
(PBE) functional including van der Waals (vdW) interactions, in combination
with infrared spectroscopy and temperature-programmed desorption (TPD)
experiments, reveal the reaction pathway between the weakly chemisorbed
reactant (C<sub>9</sub>H<sub>14</sub>O) and the strongly chemisorbed
product (C<sub>9</sub>H<sub>10</sub>O), which occurs by the cleavage
of four C–H bonds below 250 K. Analysis of the TPD spectrum
is consistent with the relatively small magnitude of the activation
barrier derived from PBE+vdW calculations, demonstrating the feasibility
of low-temperature dehydrogenation