The Effect of Office Chair Backrest Design on the Body\u27s Metabolic Response to Office Work

Most office chairs have a backrest that is wider at the shoulders than at the hips. Recently, a new office chair was developed that has a backrest that is narrower at the shoulders and wider at the hips (upwardly tapered backrest). The upwardly tapered backrest should allow users to increase their ventilatory efficiency, compared to a conventional, wide backrest. This new backrest design will hypothetically allow a user to retract their scapulae, increase expansion of the chest cavity, thus allowing the lungs more space to expand. Specific measures of improved ventilatory efficiency are an increase in tidal volume (Vt - liters/breath) and a decrease in respiratory rate (RR - breaths/min). Ventilatory and cardiovascular metabolic variables were measured from 31 office workers sitting in 2 chairs (conventional and upwardly tapered). The Cortex Metamax 3B system (Leipzig, Germany) was used to measure VO2 , RR, Vt and heart rate (HR - beats per min). Each participant performed 8 tasks in each chair. The tasks included typing, searching the internet, creating a spreadsheet, and watching a movie. Physiologic data were collected throughout testing. The subjects were blinded to which chair the test chair was. Results indicated no significant differences in users\u27 RR and Vt between the two chairs, but the users did have a significantly lower HR when they sat in the chair with the upwardly tapered backrest (3 to 7 bpm less). Heart rate has been shown to be a risk factor of heart disease, and thus the test chair could reduce the impact of a risk factor of heart disease in office workers. Analysis of subjective assessment data did not show any overall preference for either chair

Gamma ray emission from the region of the galactic center

A combination nuclear emulsion-spark chamber gamma ray (E=100 MeV) telescope was used to study the region of sky that includes the Galactic Center. 95% confidence upper limits on the flux from the reported sources G gamma 2 - 3 and Sgr gamma-1 were placed at 4.4 and 8.8 x 10 to the minus 5th power protons/sq cm-sec, and a similar limit on the emission from the Galactic Center as a point source (plus or minus .75 degrees) was placed at 3.3 x 10 to the minus 5th power protons/sq cm-sec. No enhanced emission was observed from the Galactic Plane (plus or minus 6 degrees) and an upper limit of 2 x 10 to the minus 4th power protons/sq cm-sec rad/ was obtained

Outdoor music festivals: Cacophonous consumption or melodious moderation?

Large outdoor music festivals have emerged as part of a general expansion of licensed recreational activities, but in research terms they have been largely impenetrable due to commercial sensitivities. These sensitivities notwithstanding, the number and scale of such events necessitate a greater understanding of alcohol and drug use and the potential to promote normative protective behaviours in this context. This study examines self-reported alcohol and drug behaviours of 1589 attendees at a music festival in Scotland during the summer of 2008. Similarities between the outdoor rock music festivals and the dance club scene are considered alongside the challenges associated with risk reduction in these settings. Results show that alcohol was consumed by the majority of samples; however, negative consequences were reported by a minority of respondents, suggesting evidence of controlled hedonism within a situation traditionally associated with unrestrained excess. Similarly, the majority of samples did not use drugs. The majority also report a number of self-regulating protective behaviours suggesting that alcohol and drug use is contained within a developing social culture of ‘controlled intoxication’. Results further suggest that although music festivals are transitory events, there is a degree of consistency amongst attendees. Music festivals may therefore be atypical but potentially effective environments to increase protective behaviours using normative messaging and modern communications media. This study was resourced exclusively by local alcohol and drug partnerships

Biomechanical Effects of Mobile Computer Location in a Vehicle Cab

Objective: The objective of this research is to determine the best location to place a conventional mobile computer supported by a commercially available mount in a light truck cab. Background: U.S. and Canadian electric utility companies are in the process of integrating mobile computers into their fleet vehicle cabs. There are no publications on the effect of mobile computer location in a vehicle cab on biomechanical loading, performance, and subjective assessment. Method: The authors tested four locations of mobile computers in a light truck cab in a laboratory study to determine how location affected muscle activity of the lower back and shoulders; joint angles of the shoulders, elbows, and wrist; user performance; and subjective assessment. A total of 22 participants were tested in this study. Results: Placing the mobile computer closer to the steering wheel reduced low back and shoulder muscle activity. Joint angles of the shoulders, elbows, and wrists were also closer to neutral angle. Biomechanical modeling revealed substantially less spinal compression and trunk muscle force. In general, there were no practical differences in performance between the locations. Subjective assessment indicated that users preferred the mobile computer to be as close as possible to the steering wheel. Conclusion: Locating the mobile computer close to the steering wheel reduces risk of injuries, such as low back pain and shoulder tendonitis. Application: Results from the study can guide electric utility companies in the installation of mobile computers into vehicle cabs. Results may also be generalized to other industries that use trucklike vehicles, such as construction

Regulation of the ESC transcriptome by nuclear long non-coding RNAs

Long noncoding (lnc)RNAs have recently emerged as key regulators of gene expression. Here, we performed high-depth poly(A)+ RNA sequencing across multiple clonal populations of mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) to comprehensively identify differentially regulated lncRNAs. We establish a biologically robust profile of lncRNA expression in these two cell types and further confirm that the majority of these lncRNAs are enriched in the nucleus. Applying weighted gene co-expression network analysis, we define a group of lncRNAs that are tightly associated with the pluripotent state of ESCs. Among these, we show that acute depletion of PAT-14 using antisense oligonucleotides impacts the differentiation- and development-associated gene expression program of ESCs. Furthermore, we demonstrate that Firre, a lncRNA highly enriched in the nucleoplasm and previously reported to mediate chromosomal contacts in ESCs, controls a network of genes related to RNA processing. Together, we provide a comprehensive, up-to-date and high resolution compilation of lncRNA expression in ESCs and NPCs and show that nuclear lncRNAs are tightly integrated into the regulation of ESC gene expression

Effects of external boost compression on gas turbine performance in an advanced CPFBC application

When a commercial gas turbine, designed and optimized for natural gas fuel, is used in an Advanced Circulating Pressurized Fluid Bed Combustor (CPFBC) application, changes occur that affect both the thermodynamic cycle and the performance of the individual components. These come principally from the increased pressure drop encountered between the compressor discharge and expander inlet, with changes in gas properties and flow rates for the hot combustion products having secondary effects. Net effect is that power output can be reduced and significant design and/or operational compromises may be required for the gas turbine. Application of an external boost compressor can mitigate these effects

Applications of [131I]m-iodobenzylguanidine ([131I]MIBG)

The development of the aralkylguanidine [131I]m-iodobenzylguanidine ([131I]MIBG) in the University of Michigan Nuclear Medicine Division has led to diagnostic and therapeutic evaluations of all the neuroendocrine tumors. These tumors share the property of uptake, storage and release of [131I]MIBG uptake in chromaffin granules. This property has allowed the detection of pheochromocytomas, the detection of metastases in 46% of such patients, the treatment of malignant pheochromocytomas, the detection of neuroblastoma metastases, the treatment of neuroblastomas and the detection of a percent of apudomas. We have learned how to improve our results and this is discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26908/1/0000474.pd

Primary melanoma of the prostate: case report and review of the literature

Background: Primary melanoma of the prostate has an extremely rare incidence. Only five cases have been reported in the literature and prognosis is poor. The most likely origin of prostatic melanoma is the transitional epithelium of the prostatic urethra. Surgical care for primary melanoma of mucosal sites is less well established than for primary cutaneous melanoma, but excision of the primary is recommended if the patient has no systemic disease. Case presentation: Here, we describe a case of primary malignant melanoma of the prostate. A 37-year-old male patient with history of both chemo- and radiation therapy for Hodgkin’s disease was admitted to the University Hospital Heidelberg on suspicion of pleomorphic sarcoma of the bladder. In-house diagnostic work-up revealed a malignant melanoma of the prostate. We then performed radical prostatectomy with extended lymphadenectomy. Despite presumably curative surgery, the patient suffered from early relapse of disease with pulmonary metastasis. Systemic chemotherapy and subsequent immuno-oncologic treatment was thereafter initiated. Conclusion: Since prostatic melanoma is a rare disease and a melanoma metastasis of unknown primary is the differential diagnosis, a multidisciplinary approach including early imaging to rule out possible metastases and to search for another potentially existing primary is advisable. To prevent complications related to local tumor progression and to receive tissue for mutational analysis, we recommend complete surgical resection to reduce the tumor mass. Novel immune and targeted oncologic therapies can lead to an improved survival in some cases and support of clinical trials is needed

Investigation of cell adhesion in chitosan membranes for peripheral nerve regeneration

Peripheral nerve injuries have produced major concerns in regenerative medicine for several years, as the recovery of normal nerve function continues to be a significant clinical challenge. Chitosan (CHT), because of its good biocompatibility, biodegradability and physicochemical properties, has been widely used as a biomaterial in tissue engineering scaffolding. In this study, CHT membranes were produced with three different Degrees of Acetylation (DA), envisioning its application in peripheral nerve regeneration. The three CHT membranes (DA I: 1%, DA II: 2%, DA III: 5%) were extensively characterized and were found to have a smooth and flat surface, with DA III membrane having slightly higher roughness and surface energy. All the membranes presented suitable mechanical properties and did not show any signs of calcification after SBF test. Biodegradability was similar for all samples, and adequate to physically support neurite outgrowth. The in vitro cell culture results indicate selective cell adhesion. The CHT membranes favoured Schwann cells invasion and proliferation, with a display of appropriate cytoskeletal morphology. At the same time they presented low fibroblast infiltration. This fact may be greatly beneficial for the prevention of fibrotic tissue formation, a common phenomenon impairing peripheral nerve regeneration. The great deal of results obtained during this work permitted to select the formulation with the greatest potential for further biological tests.This work has received funding from the European Community's Seventh Framework Programme (FP7-HEALTH-2011) under grant agreement no 278612 (BIOHYBRID). This study was also funded by European Union's FP7 Programme under grant agreement no REGPOT-CT2012-316331-POLARIS.The authors thank the chitosan raw material provided by Altakitin S.A., (Lisboa, Portugal). We are further thankful to Silke Fischer, Natascha Heidrich, Kerstin Kuhlemann, Jennifer Metzen, Hildegard Streich and Maike Wesemann (all from the Institute of Neuroanatomy, Hannover Medical School) for their technical support