Effects of orthostatic hypotension on cognition in Parkinson's disease

OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design. METHODS: Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture. RESULTS: The PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention). Upright posture exacerbated and broadened these deficits in the PDOH group to include phonemic fluency, psychomotor speed, and auditory working memory. When group-specific supine scores were used as baseline anchors, both PD groups showed cognitive changes following tilt, with the PDOH group exhibiting a wider range of deficits in executive function and memory as well as significant changes in visuospatial function. CONCLUSIONS: Cognitive deficits in PD have been widely reported with assessments performed in the supine position, as seen in both our PD groups. Here we demonstrated that those with PDOH had transient, posture-mediated changes in excess of those found in PD without OH. These observed changes suggest an acute, reversible effect. Understanding the effects of OH due to autonomic failure on cognition is desirable, particularly as neuroimaging and clinical assessments collect data only in the supine or seated positions. Identification of a distinct neuropsychological profile in PD with OH has quality of life implications, and OH presents itself as a possible target for intervention in cognitive disturbance.Accepted manuscriptAccepted manuscrip

Author response: Effects of orthostatic hypotension on cognition in Parkinson disease

OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in persons with Parkinson's disease (PD) without dementia. METHODS: There were 55 participants: 37 non-demented individuals with idiopathic PD, including 18 with OH (PDOH), and 19 without (PDWOH), and18 control participants (C). All participants completed neuropsychological tests in the supine and in the upright tilted position. Blood pressure was assessed in each posture using a standardized oscillometric cuff at the right brachial artery. RESULTS: The two PD groups performed similarly while supine, with a profile notable for executive dysfunction consisting of deficits in sustained attention, response inhibition, and semantic verbal fluency, as well as reduced verbal memory encoding and retention. When upright, these deficits were exacerbated and broadened to include additional cognitive functions in the PDOH group: deficits in phonemic verbal fluency, psychomotor speed, and both basic and complex aspects of auditory working memory. When group-specific supine scores were used as baseline anchors, both PD groups showed cognitive changes following tilt, though the PDOH group had a wider range of deficits in the executive functioning and memory domains and was the only group to show significant changes in visuospatial skills. CONCLUSIONS: Cognitive deficits in idiopathic PD have been widely reported, though assessments are typically performed in the supine position. While both PD groups had supine deficits that aligned with prior studies and clinical findings, we demonstrated that those with PD and orthostatic hypotension had transient, posture-mediated changes in excess of those found in PD without autonomic failure. These observed changes suggest an acute, reversible effect, and as orthostatic hypotension is a significant comorbid factor in PD, an independent target for clinical intervention. Further understanding of the effects of autonomic failure on cognition in other disorders is desirable, particularly in the context of neuroimaging studies and clinical assessments where data are collected only in the supine or seated positions. Identification of a distinct neuropsychological profile in PD with autonomic failure also has implications for functional activities of daily living and overall quality of life.Accepted manuscrip

Detection, photometry and slitless radial velocities of 535 planetary nebulae in the flattened elliptical galaxy NGC 4697

We have detected 535 planetary nebulae (PNs) in NGC 4697, using the classic on-band, off-band filter technique with the Focal Reducer and Spectrograph (FORS) at the Cassegrain focus of the first 8-meter telescope unit of the ESO Very Large Telescope. From our photometry we have built the [O III] 5007 planetary nebula luminosity function (PNLF) of NGC 4697. It indicates a distance of 10.5 Mpc, substantially smaller than a previous estimate of 24 Mpc used in earlier dynamical studies. The PNLF also provides an estimate of the specific PN formation rate. Combining the information from on-band images with PN positions on dispersed, slitless grism images, we have obtained radial velocities for 531 of the 535 PNs. They provide kinematic information up to a distance of almost three effective radii from the nucleus. Some rotation is detected in the outer regions, but the rotation curve of this galaxy appears to drop beyond one effective radius. Assuming an isotropic velocity distribution, the velocity dispersion profile is consistent with no dark matter within three effective radii of the nucleus (however, some dark matter can be present if the velocity distribution is anisotropic). We obtain a blue mass-to-light ratio of 11. Earlier M/L ratios for NGC 4697 were too small, because of the too large distance used for their derivation.Comment: 52 pages, 24 Postscript figures, ApJ 2001, in pres

Validity of the activPAL3 activity monitor in people moderately affected by Multiple Sclerosis

Background: Walking is the primary form of physical activity performed by people with Multiple Sclerosis (MS), therefore it is important to ensure the validity of tools employed to measure walking activity. The aim of this study was to assess the criterion validity of the activPAL3 activity monitor during overground walking in people with MS.\ud Methods: Validity of the activPAL3 accelerometer was compared to video observation in 20 people moderately affected by MS. Participants walked 20-30m twice along a straight quiet corridor at a comfortable speed.\ud Results: Inter-rater reliability of video observations was excellent (all intraclass correlations > 0.99). The mean difference (activPAL3- mean of raters) was -4.70 ± 9.09, -4.55 s ± 10.76 and 1.11 s ± 1.11 for steps taken, walking duration and upright duration respectively. These differences represented 8.7, 10.0 and 1.8% of the mean for each measure respectively. The activPAL3 tended to underestimate steps taken and walking duration in those who walked at cadences of ≤ 38 steps/minute by 60% and 47% respectively.\ud Discussion: The activPAL3 is valid for measuring walking activity in people moderately affected by MS. It is accurate for upright duration regardless of cadence. In participants with slow walking cadences, outcomes of steps taken and walking duration should be interpreted with caution

Project for the analysis of technology transfer Quarterly report, 1 Apr. 1969 - 30 Jun. 1969

Patterns, statistical analyses, and case studies of transfer and utilization of NASA generated technolog

Theory of Coupled Multipole Moments Probed by X-ray Scattering in CeB6_6

A minimal model for multipole orders in CeB$_6$ shows that degeneracy of the quadrupole order parameters and strong spin-orbit coupling lead to peculiar temperature and magnetic-field dependences of the X-ray reflection intensity at superlattice Bragg points. Furthermore, the intensity depends sensitively on the surface direction. These theoretical results explain naturally recent X-ray experiments in phases II and III of CeB$_6$. It is predicted that under weak magnetic field perpendicular to the (111) surface, the reflection intensity should change non-monotonically as a function of temperature.Comment: 4 pages, 5 figure

Electronic structure and light-induced conductivity in a transparent refractory oxide

Combined first-principles and experimental investigations reveal the underlying mechanism responsible for a drastic change of the conductivity (by 10 orders of magnitude) following hydrogen annealing and UV-irradiation in a transparent oxide, 12CaO.7Al2O3, found by Hayashi et al. The charge transport associated with photo-excitation of an electron from H, occurs by electron hopping. We identify the atoms participating in the hops, determine the exact paths for the carrier migration, estimate the temperature behavior of the hopping transport and predict a way to enhance the conductivity by specific doping.Comment: 4 pages including 4 figure

Discovery of 9 Ly alpha emitters at redshift z~3.1 using narrow-band imaging and VLT spectroscopy

Narrow-band imaging surveys aimed at detecting the faint emission from the 5007 [O III] line of intracluster planetary nebulae in Virgo also probe high redshift z=3.1 Ly alpha emitters. Here we report on the spectroscopic identification of 9 Ly alpha emitters at z=3.13, obtained with the FORS spectrograph at Unit 1 of the ESO Very Large Telescope (VLT UT1). The spectra of these high redshift objects show a narrow, isolated Ly alpha emission with very faint (frequently undetected) continuum, indicating a large equivalent width. No other features are visible in our spectra. Our Ly alpha emitters are quite similar to those found by Hu (1998), Cowie & Hu (1998) and Hu et al. (1998). Using simple population synthesis models, on the assumption that these sources are regions of star formation, we conclude that the nebulae are nearly optically thick and must have a very low dust content, in order to explain the high observed Ly alpha equivalent widths. For the cosmological and star formation parameters we adopted, the total stellar mass produced would seem to correspond to the formation of rather small galaxies, some of which are perhaps destined to merge. The implied star formation density in our sampled comoving volume is probably somewhat smaller than, but of the same order of magnitude as the star formation density at z=3 derived by other authors from Lyman-break galaxy surveys. This result agrees with the expectation that the Ly alpha emitters are a low-metallicity (or low-dust) tail in a distribution of star forming regions at high redshifts. Finally, the Ly alpha emitters may contribute as many H-ionizing photons as QSOs at z=3.Comment: 26 pages, 17 Postscript figures, ApJ in pres

Radiocarbon and blue optically stimulated luminescence chronologies of the Oitavos consolidated dune (Western Portugal)

The dune of Oitavos, the underlying paleosol, and Helix sp. gastropod shells found within the paleosol were dated using a combination of radiocarbon and blue optically stimulated luminescence (OSL). The organic component of the paleosol produced a significantly older age (~20,000 cal BP) than the OSL age measurement (~15,000 yr), while 14C age measurements on the inorganic component and the gastropods produced ages of ~35,000 yr and ~34,000 yr, respectively. Rare-earth element analyses provide evidence that the gastropods incorporate geological carbonate, making them an unreliable indicator of the age of the paleosol. We propose that the 14C age of the small organic component of the paleosol is also likely to be unreliable due to incorporation of residual material. The OSL age measurement of the upper paleosol (~15,000 yr) is consistent with the age for the base of the dune (~14,500 yr). The younger OSL age for the top of the dune (~12,000 yr) suggests that it was built up by at least 2 sand pulses or that there was a remobilization of material at the top during its evolution, prior to consolidation

Cortical phase transitions, non-equilibrium thermodynamics and the time-dependent Ginzburg-Landau equation

The formation of amplitude modulated and phase modulated assemblies of neurons is observed in the brain functional activity. The study of the formation of such structures requires that the analysis has to be organized in hierarchical levels, microscopic, mesoscopic, macroscopic, each with its characteristic space-time scales and the various forms of energy, electric, chemical, thermal produced and used by the brain. In this paper, we discuss the microscopic dynamics underlying the mesoscopic and the macroscopic levels and focus our attention on the thermodynamics of the non-equilibrium phase transitions. We obtain the time-dependent Ginzburg-Landau equation for the non-stationary regime and consider the formation of topologically non-trivial structures such as the vortex solution. The power laws observed in functional activities of the brain is also discussed and related to coherent states characterizing the many-body dissipative model of brain.Comment: 19 pages, 4 figures, research pape