9 research outputs found
The Geopolitics of the Iran Nuclear Negotiations
- Author
- Publication venue
- NUPI
- Publication date
- 01/01/2014
- Field of study
I sin geopolitiske analyse av atomvÄpenforhandlingene i Iran, pÄpeker Charles W. Freeman at Iran i praksis har de samme uvennene i MidtÞsten som Vesten har, om enn ikke de samme vennene. En avtale vil gi en bedre sjanse bÄde for landene i og utenfor regione Ä samles i en felles innsats mot ekstremisme. En avtale trenger nÞdvendigvis ikke Ä medfÞre at dette lykkes, men uten, vil mulighetene vÊre ikke-eksisterende. Enda en forlengelse av forhandlingsfristen vil fullstendig mangle troverdighet, og vil til en viss grad gi de samme negative konsekvensene som mislykket avtale ville gi
Protein sensitization and kindred phenomena
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The present status of investigation of varietal resistance to disease in the potato
- Author
- A. H. Gilbert
- Chas D. Woods
- Donald Reddick
- E. S. Schultz
- E. S. Schultz
- E. S. Schultz
- E. S. Schultz
- F. W. Rane
- Freeman Weiss
- G. H. Pethybridge
- H. A. Edson
- H. M. Jennison
- H. W. Wollenweber
- J. Arthur Harrts
- Just Aumiot
- L. A. Hawkins
- L. R. Jones
- O. A. Pratt
- O. A. Pratt
- O. Appel
- Paul A. Murphy
- Philip Brierley
- R. J. Haskell
- R. N. Salaman
- W. T. Macoun
- William J. Green
- Wm Stuart
- Wm. Stuart
- Wm. Stuart
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Constructing international relations: The role of transnational migrants and other nonâstate actors
- Author
- _____
- _____
- _____
- _____
- Appadurai Arjun
- Barston R. P.
- Basch Linda
- Bernal Victoria
- Canclini NĂ©stor GarcĂa
- Carvajal Doreen
- Danforth Loring
- Escobar Arturo
- Fanon Franz
- FeldmanâBianco Bela
- Foner Nancy
- Freeman Chas W.
- Funkhouser Edward
- Gamson W. A.
- Georges Eugenia
- Glick Schiller Nina
- Glick Schiller Nina
- Glick Schiller Nina
- Goldring Luin
- Gonzalez Gutierrez Carlos
- Grasmuck Sherri
- Guarnizo Luis Eduardo
- HondagneuâSotelo Pierrette
- Kearney Michael
- Korten David C.
- Kyle David
- Loescher Gil
- Lungo Mario
- MacCannell Dean
- Mahler Sarah J.
- Marshall Peter
- Massey Douglas S.
- Mato Daniel
- McCarthy J. D.
- Mitchell Christopher
- Montes Mozo Segundo
- Myoshi Masao
- Nagengast Carole
- Ong Aihwa
- Paul Shuva
- Piven Frances Fox
- Portes Alejandro
- Reimers Fernando
- Rhoades Robert E.
- Richman Karen
- Sarah J. Mahler
- Scott James C.
- Sider Gerald
- Smith Robert C.
- Thompson E. P.
- Tilly Charles
- Wallerstein Emmanuel
- Webster
- Wyman Mark
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Sex offender as homo sacer
- Author
- Agamben Giorgio
- Agamben Giorgio
- Agamben Giorgio
- Akerstrom M.
- Arendt Hannah
- Aristotle
- Bauman Zygmunt
- Beccaria Cesare
- Bell Vikki
- Brown Sarah
- Canetti Elias
- Carey Allison
- Cotter Ryan
- Cowburn M.
- Critcher Chas
- Dale Spencer
- Douglas Mary
- Durkheim Emile
- Eliot Thomas D.
- Foucault Michel
- Freeman-Longo R.
- Freeze Colin
- Garland David
- Garland David
- Genel Katia
- Jenkins Philip
- Kitzenger Jenny
- Levi Ron
- Levi Ron
- Logan W.
- Lynch M.
- Meyer Walter J.
- Miller R.D.
- Nunn Samuel
- Overboe James
- Overboe James
- Payne B.
- Petrunik Michael
- Petrunik Michael
- Prassel Frank
- Pratt Anna
- Pratt John
- Pratt John
- Pratt John
- Pugh Ralph B.
- Rajaram Prem Kumar
- Renzema Marc
- Rose Nikolas
- Schmitt Carl
- Scott Charles L.
- Simon J.
- Simon J.
- Stanko Elizabeth
- Vasquez Michael
- Weinberger Linda E.
- Zevitz Richard
- Zevitz Richard G.
- Zippelius R.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
The Makings of Modern Humanitarian Interventions: Interplay of Interests and Norms in the Kosovo Crisis
- Author
- ( Yugoslavia
- Adam Roberts
- Adam Roberts
- Alex J Bellamy
- Alex J Bellamy
- Alexander Wendt
- Ancu?a-Gabriela Tarta
- Andrew Sullivan
- Balkan Devlen
- Bill Clinton
- Bill Clinton
- Branimir Krstic
- Buzan
- Carole Rogel
- Carr
- Carr
- Charles Babington
- Charles Krauthammer
- Charles Krauthammer
- Chas Freeman
- Clark
- Clark
- Clark
- Cristian Staub
- Del Fernando
- Donnelly
- Doreen K Allerkamp
- Fareed Zakaria
- Finnemore
- Finnemore
- For Constructivist
- Gilles Andrïżœani
- H Ivo
- Hans J Morgenthau
- Holzgrefe
- Huth
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- J Alynna
- J Hans
- J Mark
- Javier Solana
- John
- John F Harris
- John J Mearsheimer
- Joshua S Goldstein
- K Paul
- Ken Booth
- Kosovo Malcolm
- Laura Neack
- Lippman
- Mandelbaum
- Mandelbaum
- Mandelbaum
- Matthew W Herbert
- Michael Gilligan
- Michael Mandelbaum
- Miranda Vickers
- Morgenthau
- Morgenthau
- Neack
- Peter Gowan
- Peter Lippman
- Rasmus Tenbergen
- Richard Perkins
- Rodley Franck
- Roy Allison
- Saving Wheeler
- Saving Wheeler
- Saving Wheeler
- Schmidt Dunne
- Schmidt Dunne
- Schmidt Dunne
- See Michael Mandelbaum
- Seung-Whan Choi
- Sidita Kushi
- Smith Latawski
- Statistical Office
- Stedman Gilligan
- Steven Pinker
- Tenbergen
- Thucydides
- Tim Judah
- Timothy Hildebrandt
- Vïżœclav Havel
- Wesley K Clark
- Wheeler
- Wheeler
- Wheeler Bellamy
- ïżœzdamar Devlen
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
China and American Seapower in East Asia: Is Accommodation Possible?
- Author
- Armitage Richard L.
- Art Robert J.
- Art Robert J.
- Auer James E.
- Auslin Michael
- Axelrod Robert
- Blackwill Robert D.
- Blair Dennis
- Blumenthal Dan
- Blumenthal Dan with Randall Schriver, Mark Stokes, L.C. Russell Hsiao and Michael Mazza
- Brzezinski Zbigniew
- Carpenter Ted Galen
- Carpenter Ted Galen
- Cha Victor D.
- Chase Michael S.
- Cheng Dean
- Cheng Xizhong
- Christensen Thomas J.
- Churchill R.R.
- Clark Ian
- Cossa Ralph
- Davis Van Wie
- Denmark Abraham M.
- Dutton Peter
- Dutton Peter A.
- Flemming Brian
- Freeman Amb. Chas
- Gholz Eugene
- Gilley Bruce
- Glaser Charles
- Gompert David C.
- Griffiths David
- Group International Crisis
- Guoxing Ji
- Hsu Kimberly
- Iida Masafumi
- James Manicom
- Kaplan Robert
- Kraska James
- Kugler Jacek
- Kuriyama Takakazu
- Lee Jae-hyung
- Luo Yuan
- Mahnken Thomas G.
- Mandelbaum Michael
- Manicom James
- Marciel Scot
- Mead Walter Russel
- Mearsheimer John J.
- Mearsheimer John J.
- Muller David G.
- Nan Li
- Ocean Policy Research Foundation
- Office of International Security Affairs
- Office of the Press Secretary
- Office of the Secretary of Defense
- Office of the Secretary of Defense
- Organski A.F.K.
- Parent Joseph M.
- Posen Barry R.
- Ren Xiaofeng
- Richardson Michael
- Shen Dingli
- Smith Robert W.
- Smith Robert W.
- Swaine Michael D.
- Taylor Fravel M.
- Thayer Carlyle A.
- Tillman Barrett
- Tonelson Alan
- Valencia Mark
- Van Dyke John M.
- Van Dyke John M.
- Wachman Alan
- Walt Stephen M.
- White Hugh
- Xinbo Wu
- Yang Yi
- Zhang Haiwen
- Zhang Jingwei
- Zhang Wenmu
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
- Biello K
- Biello K
- Bii S
- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
- Bivol S
- Black D
- Blantari J
- Blick G
- Blumenthal S
- Bock N
- Boivin M
- Boleo C
- Boleo C
- Bolton-Moore C
- Bond V
- Bonnecwe C
- Bonnington O
- Bonnington O
- Bonzela J
- Boonsuk S
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Bor J
- Borkird T
- Borquez A
- Bose M
- Bosomprah S
- Bouchaud O
- Boulle A
- Boum Y
- Bouzas M
- Bowman B
- Boyd A
- Boyd R
- Boyer S
- Boyer S
- Boyes M
- Bozinoff N
- Bozzi G
- Bradley J
- Brahmbhatt H
- Brainard D
- Brand R
- Bredeek U
- Brenchley J
- Brennan A
- Brennan A
- Brennan A
- Brennan C
- Brennan D
- Brewster-Lee D
- Brezak A
- Brigham F
- Brigstock-Barron O
- Brill I
- Brill I
- Brittain K
- Britto P
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brooks R
- Brooks-Pollock E
- Brothers J
- Brotto L
- Brouwers P
- Brown E
- Brown G
- Brown H
- Brown L
- Browning R
- Browning R
- Brummel S
- Brummel S
- Bryant H
- Bryant K
- BrÀu N
- Bucek A
- Bucek A
- Buchanan A
- Buehler S
- Bukenya D
- Bukenya D
- Bukenya D
- Bukowski L
- Bukowski L
- Bukusi D
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bukusi E
- Bulterys M
- Bulya N
- Bulya N
- Bunu A
- Burchett S
- Burgener A
- Burke S
- Burman W
- Burmeister S
- Burton R
- Burwitz B
- Busch M
- Busch M
- Busza J
- Bwakura-Dangarembizi M
- Bwakura-Dangarembizi M
- Bwana M
- Bygrave H
- Byrareddy S
- Byrd J
- Byrne E
- BĂ€rnighausen T
- BĂ€rnighausen T
- Cadigan J
- Cahn P
- Cahn P
- Cai F
- Cai Y
- Cale E
- Cambiano V
- Cameron D
- Cameron P
- Campa A
- Campbell
- Campbell T
- Candrinho B
- Capitant C
- Capitant C
- Caraulan L
- Cardenas-Ochoa A
- Cardoso J
- Carias A
- Carlson J
- Carmona S
- Carmona S
- Carmona S
- Carmona S
- Carneiro P
- Carnimeo V
- Carolus G
- Carrasco M
- Carrington M
- Carroll R
- Carter A
- Casado J
- Casavant I
- Cassell M
- Castellanos E
- Castelnuovo B
- Cathcart R
- Catranji V
- Cattamanchi A
- Cawley C
- Cawley C
- Cawood C
- Cawood C
- Cawood C
- Cazein F
- Cecchini D
- Cecilio M
- Celum C
- Celum C
- Celum C
- Celum C
- Ceranto A
- Chabala C
- Chabata S
- Chabeda S
- Chakhtoura N
- Chakhtoura N
- Chakhtoura N
- Chamanga R
- Chamie G
- Chanaiwa V
- Chandawale A
- Chandra C
- Chandra S
- Chang E
- Chang M
- Chang W
- Changalucha J
- Chapman S
- Chappell E
- Charlebois E
- Charlebois E
- Charlebois E
- Charlebois E
- Charoenying S
- Charreau I
- Charreau I
- Chas J
- Chas J
- Chasanov
- Chaturvedi S
- Chaudhury S
- Chege W
- Chelbi-Alix M
- Chemhuru M
- Chen C-H
- Chen L
- Chen M
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng H
- Cheng Z
- Cheu R
- Chidiac C
- Chigayo M
- Chihana NK
- Chikandiwa A
- Chikandiwa A
- Chikonda J
- Chileshe C
- Chilima B
- Chilima B
- Chilongani J
- Chimanpure V
- Chimbetete C
- Chimbetete C
- Chime C
- Chinkonde J
- Chinsinga B
- Chipadze
- Chipeta Z
- Chipungu J
- Chirchir B
- Chirowodza A
- Chirwa E
- Chirwa E
- Chirwa Z
- Chiyaka T
- Chomba E
- Chomba E
- Chomchey N
- Chomont N
- Chomont N
- Chopera D
- Chung A
- Church K
- Church K
- Cianci G
- Cicala C
- Clark T
- Clark T
- Clark T
- Clarke A
- Clarke K
- Clotet B
- Cluver L
- Cluver L
- Coffey-Esquivel J
- Cofield S
- Cohen
- Cohen C
- Cohen C
- Cohen C
- Cohen K
- Cohort S
- Cole M
- Colebunders R
- Coletti A
- Coletti A
- Collins I
- Collins S
- Colua E
- Come J
- Comstock L
- Condo J
- Contreras D
- Contreras-Loya D
- Conway D
- Cook A
- Coombs J-A
- Coombs R
- Cooper D
- Cooper D
- Cooper K
- Copas A
- Corbelli G
- Corey L
- Coris
- Corrigan B
- Cossa L
- Costagliola D
- Costiniuk C
- Cotte L
- Couderc C
- Coulibaly A
- Coulter R
- Cowan F
- Cowan F
- Cowan F
- Crampin A
- Crandall B
- Cranston R
- Crauwels H
- Crooks E
- Crosno K
- Crouch P-C
- Cua E
- Cuembelo F
- Cummins N
- Curran K
- Currier J
- Currier J
- Curtis P
- Custer B
- Czaicki N
- D'Angelo L
- D'Aquila R
- Dabis F
- Daho S
- Dalal S
- Dam K
- Danboise B
- Danel C
- Dange A
- Daniel C
- Daniels B
- Darbes L
- Darong G
- Darr E
- Daskalakis D
- Daskilewicz K
- Datong P
- Davenport M
- Davey C
- Davey DJ
- Davies M-A
- Davies N
- Davis S
- Davis VR
- Davis W
- Dawood H
- Dawood H
- Dawson L
- Dayton F
- Ddaaki W
- Ddaaki W
- Ddaaki W
- De Castro D
- De Gruttola V
- De Jong B
- de la Grecca R
- de Lima Pereira ME
- de Lima CE
- de Oliveira T
- De Oliveira T
- de Pedro A
- de Pokomandy A
- de Roubaix M
- de Schacht C
- de Souza M
- de Souza MB
- de Vries H
- Decker M
- Decroo T
- del Amo J
- Del Prete G
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delany-Moretlwe S
- Delate R
- Delaugerre C
- Delfraissy J-F
- Dellar R
- Demeri D
- Denny T
- Desbiens M
- Deuba K
- Devieux J
- Dewar R
- Deyde V
- Dezembro S
- Dezutti C
- Dhilpe V
- Dhodho M
- Di Giano L
- Dias PG
- Diergaardt C
- Diez-Martin J
- Dikgale F
- Dikobe W
- Dimba A
- Dinanga JD
- Dinapoli S
- Dindi P
- Dindi P
- Ding E
- Diop A
- Diouf D
- DiPaola A
- Dirawo J
- Diseko M
- Dlamini D
- Doehle B
- Doerholt K
- Doherty T
- Dolezal C
- Dolezal C
- Donaldson E
- Donastorg Y
- Doncel G
- Dong K
- Dong K
- Donnell D
- Donnelly A
- Dores CD
- Dorey D
- Doria-Rose N
- Dorvil N
- Doré V
- Dos Santos N
- Dougherty G
- Dow W
- Dowdy D
- Dowsett G
- Drain P
- Drame F
- Dray-Spira R
- Dreyer J
- Dronda F
- du Lou AD
- Dube F
- Dube K
- Dube K
- Dube M
- Dubuc D
- Duby Z
- Dubé K
- Duck T
- Duerr A
- Duffill K
- Dumont E
- Dunkle K
- Dunn D
- Dunsmore T
- Dunsmore T
- Durand-Zaleski I
- Dutrieux J
- Dutta A
- Duverger L
- Dvoriak S
- Dzekedzeke K
- Dzissyuk N
- Dzoro S
- DĂaz A
- Eba P
- Ebagua I
- Eckard M
- Ecochard R
- Edelstein H
- Edick S
- Egan D
- Egan J
- Ehmer J
- Ehmer J
- Eholié S
- Ehouman S
- Ehrenkranz P
- Ekong E
- Ekström A
- El-Sadr W
- El-Sadr W
- Eley B
- Elkington K
- Elkington K
- Eller L
- Ellman T
- Ellman T
- Ellman T
- Ellman T
- Else L
- Emel L
- Emel L
- Emery S
- Emusu D
- Engstrom J
- Erekaha S
- Ericsen A
- Ernest O
- Eshleman S
- Esiru G
- Essex M
- Essex M
- Essex M
- Estes J
- Estes J
- Etard J-F
- Etard J-F
- Etima J
- Etyang T
- Eubanks K
- Evans D
- Evans D
- Evans M
- Evans-Frantz I
- Ezouatchi R
- Faden R
- Fagan T
- Fahey C
- Fair C
- Fairley C
- FalcĂł V
- Familiar I
- Fantus S
- Farley S
- Farley T
- Farquhar C
- Fast D
- Fatti G
- Fatti G
- Fauci A
- Faustin M
- Faye S
- Fayorsey R
- Fearon E
- Felber B
- Fennessey C
- Fernandes A
- Ferrand R
- Ferrusi C
- Fidler S
- Fiebig L
- Fiedler T
- Fields S
- Fields S
- Fields S
- Fiellin D
- Figueroa M
- Figueroa M
- Finlay-Vickers A
- Finlayson T
- Fish R
- Fisher K
- Fisher M
- Flick R
- Floyd S
- Flynn P
- Fonner V
- Fonseca E
- Footer K
- Ford S
- Forster N
- Fortenberry A
- Fortunak J
- Fought A
- Fowler
- Fowler
- Fox A
- Fox A
- Fox J
- Fox J
- Fox M
- Fox M
- Fox M
- Fox M
- Fox M
- Franck D
- Frank A
- Frank S
- Fraser N
- Frater J
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated