Rematerialising Heritage

The Rocks is one of Sydney's premier tourist locations; its identity largely founded on the perception of it as a historically significant site. This perception is steeped in complex notions of the `authentic tourist experience offered at The Rocks, which arguably originates from the retention of some of the early streets and architectures of the area. However, implicit in the act of retention is also the act of deletion. Throughout the area of The Rocks, gaps exist. These are the spaces where buildings, houses, outhouses, lanes and indeed whole streets have been eradicated to make way for urban progress or to redefine areas of the city according to political or economic aims. Heritage here is constructed, not only from that which is retained and preserved but also from that which is deleted and destroyed. This paper seeks to examine the fate of one particular street in the Rocks Princes Street that was eradicated in 1927 to make way for the Sydney Harbour Bridge. The physical demolition of the street and subsequent erasure of any material sign of it has effectively allowed the street to disappear. The predominant historical narrative that results reveals the extent to which current notions of the past are fundamentally understood through the existence of the material artefact. Yet this paper argues that definitions of the past can be drawn, not only from the material or architectural object that operates as historical proof but also from the social, performative and touristic acts that might be undertaken around the object, the architecture or even its representation

Comparison of respondent-reported and sensor-recorded latrine utilization measures in rural Bangladesh: a cross-sectional study.

Background: Health improvements realized through sanitation are likely achieved through high levels of facilities utilization by all household members. However, measurements of sanitation often rely on either the presence of latrines, which does not guarantee use, or respondent-reported utilization of sanitation facilities, which is prone to response bias. Overstatement of sanitation metrics limits the accuracy of program outcome measures, and has implications for the interpretation of related health impact data. Methods: We conducted a cross-sectional study of 213 households in 14 village water, sanitation and hygiene committee clusters throughout rural Bangladesh and used a combined data- and relationship-scale approach to assess agreement between respondent-reported latrine utilization and sensor-recorded measurement. Results: Four-day household-level respondent-reported defecation averaged 28 events (inter-quartile range [IQR] 20-40), while sensor-recorded defecation averaged 17 events (IQR 11-29). Comparative analyses suggest moderately high accuracy (bias correction factor=0.84), but imprecision in the data (broad scatter of data, Pearson's r=0.35) and thus only weak concordance between measures (ρc=0.29 [95% BCa CI 0.15 to 0.43]). Conclusions: Respondent-reported latrine utilization data should be interpreted with caution, as evidence suggests use is exaggerated. Coupling reported utilization data with objective measures of use may aid in the estimation of latrine use

The metallicity distributions in high-latitudes with SDSS

We present metallicities and their variations with different parameters for 36 high-latitude fields covering Galactic longitudes 0<l<360. The metallicities for relatively short vertical distances (z<2.5 kpc) show systematic fluctuations with Galactic longitude, similar to those of the thick-disc scaleheight, which may be interpreted as indicating a common origin, viz., the flare effect of the disc. This suggestion is supported by the metallicity variations which we find as functions of radial distance. The metallicity variation at larger vertical distances (6.5<z<9.5 kpc) is small but monotonic. Three different vertical metallicity gradients could be detected: d[M/H]/dz=-0.22(+/-0.03), d[M/H]/dz=-0.38 (+/-0.06), and d[M/H]/dz=-0.08 (+/-0.07) dex/kpc for the intervals z<3, 3<z<5, and 5<z<10 kpc, respectively. Since our data cover the whole Galactic longitude interval, the resulting metallicity gradients can be interpreted as properties of the larger-scale Galaxy. The first gradient confirms the dissipational formation of the disc at short z-distances. The steeper gradient corresponds to the transition region between different population components of the Galaxy, and finally, the lowest value provides an adequate description of the inner-halo metallicity gradient.Comment: 14 pages, 7 figures and 2 tables, accepted for publication in New Astronom

The stellar metallicity distribution in intermediate latitude fields with BATC and SDSS data

Based on the Beijing-Arizona-Taiwan-Connecticut (BATC) and Sloan Digital Sky Survey (SDSS) photometric data, we adopt SEDs fitting Method to evaluate the metallicity distribution for \sim40,000 main-sequence stars in the Galaxy. According to the derived photometric metallicities of these sample stars, we find that the metallicity distribution shift from metal-rich to metal-poor with the increase of distance from the Galactic center. The mean metallicity is about of 1.5 \pm 0.2dex in the outer halo and 1.3 \pm 0.1 dex in the inner halo. The mean metallicity smoothly decreases from -0.4 to -0.8 in interval 0 < r \leq 5 kpc. The fluctuation in the mean metallicity with Galactic longitude can be found in interval 4 < r \leq 8 kpc. There is a vertical abundance gradients d[Fe/H]/dz\sim -0.21 \pm 0.05 dex kpc-1 for the thin disk (z \leq 2 kpc). At distance 2 < z \leq 5 kpc, where the thick disk stars are dominated, the gradients are about of -0.16 \pm0.06 dex kpc-1, it can be interpreted as a mixture of stellar population with different mean metallicities at all z levels. The vertical metallicity gradient is - 0.05 \pm0.04 dex kpc-1 for the halo (z > 5 kpc). So there is little or no metallicity gradient in the halo

Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial : FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study)

Background: A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and post-operative intraocular tamponade with gas, is effective for stage 2, 3 and 4 FTMH. Internal limiting membrane (ILM) peeling has been introduced as an additional surgical manoeuvre to increase the success of the surgery; i.e. increase rates of hole closure and visual improvement. However, little robust evidence exists supporting the superiority of ILM peeling compared with no-peeling techniques. The purpose of FILMS (Fullthickness macular hole and Internal Limiting Membrane peeling Study) is to determine whether ILM peeling improves the visual function, the anatomical closure of FTMH, and the quality of life of patients affected by this disorder, and the cost-effectiveness of the surgery. Methods/Design: Patients with stage 2–3 idiopathic FTMH of less or equal than 18 months duration (based on symptoms reported by the participant) and with a visual acuity ≤ 20/40 in the study eye will be enrolled in this FILMS from eight sites across the UK and Ireland. Participants will be randomised to receive combined cataract surgery (phacoemulsification and intraocular lens implantation) and pars plana vitrectomy with postoperative intraocular tamponade with gas, with or without ILM peeling. The primary outcome is distance visual acuity at 6 months. Secondary outcomes include distance visual acuity at 3 and 24 months, near visual acuity at 3, 6, and 24 months, contrast sensitivity at 6 months, reading speed at 6 months, anatomical closure of the macular hole at each time point (1, 3, 6, and 24 months), health related quality of life (HRQOL) at six months, costs to the health service and the participant, incremental costs per quality adjusted life year (QALY) and adverse events. Discussion: FILMS will provide high quality evidence on the role of ILM peeling in FTMH surgery. Trial registration: This trial is registered with Current Controlled Trials ISRCTN number 33175422 and Clinical Trials.gov identifier NCT00286507.Chief Scientist Office, Scotland (project ref no CZH/4/235), NHS GrampianPeer reviewedPublisher PD

Galactic model parameters for field giants separated from field dwarfs by their 2MASS and V apparent magnitudes

We present a procedure which separates field dwarfs and field giants by their 2MASS and V apparent magnitudes. The procedure is based on the spectroscopically selected standards, hence it is confident. We applied this procedure to stars in two fields, SA 54 and SA 82, and we estimated a full set of Galactic model parameters for giants including their total local space density. Our results are in agreement with the ones appeared recently in the literature.Comment: 10 pages, 4 figures and 5 tables, accepted for publication in A

Outlier Edge Detection Using Random Graph Generation Models and Applications

Outliers are samples that are generated by different mechanisms from other normal data samples. Graphs, in particular social network graphs, may contain nodes and edges that are made by scammers, malicious programs or mistakenly by normal users. Detecting outlier nodes and edges is important for data mining and graph analytics. However, previous research in the field has merely focused on detecting outlier nodes. In this article, we study the properties of edges and propose outlier edge detection algorithms using two random graph generation models. We found that the edge-ego-network, which can be defined as the induced graph that contains two end nodes of an edge, their neighboring nodes and the edges that link these nodes, contains critical information to detect outlier edges. We evaluated the proposed algorithms by injecting outlier edges into some real-world graph data. Experiment results show that the proposed algorithms can effectively detect outlier edges. In particular, the algorithm based on the Preferential Attachment Random Graph Generation model consistently gives good performance regardless of the test graph data. Further more, the proposed algorithms are not limited in the area of outlier edge detection. We demonstrate three different applications that benefit from the proposed algorithms: 1) a preprocessing tool that improves the performance of graph clustering algorithms; 2) an outlier node detection algorithm; and 3) a novel noisy data clustering algorithm. These applications show the great potential of the proposed outlier edge detection techniques.Comment: 14 pages, 5 figures, journal pape

Improving NFS for the Discrete Logarithm Problem in Non-prime Finite Fields

International audienceThe aim of this work is to investigate the hardness of the discrete logarithm problem in fields GF$(p^n)$ where $n$ is a small integer greater than 1. Though less studied than the small characteristic case or the prime field case, the difficulty of this problem is at the heart of security evaluations for torus-based and pairing-based cryptography. The best known method for solving this problem is the Number Field Sieve (NFS). A key ingredient in this algorithm is the ability to find good polynomials that define the extension fields used in NFS. We design two new methods for this task, modifying the asymptotic complexity and paving the way for record-breaking computations. We exemplify these results with the computation of discrete logarithms over a field GF$(p^2)$ whose cardinality is 180 digits (595 bits) long

Expression of CD33 is a predictive factor for effect of gemtuzumab ozogamicin at different doses in adult acute myeloid leukaemia

It remains unclear in adult acute myeloid leukaemia (AML) whether leukaemic expression of CD33, the target antigen for gemtuzumab ozogamicin (GO), adds prognostic information on GO effectiveness at different doses. CD33 expression quantified in 1583 patients recruited to UK-NCRI-AML17 (younger adults) and UK-NCRI-AML16 (older adults) trials was correlated with clinical outcomes and benefit from GO including a dose randomisation. CD33 expression associated with genetic subgroups, including lower levels in both adverse karyotype and core-binding factor (CBF)-AML, but was not independently prognostic. When comparing GO versus no GO (n=393, CBF-AMLs excluded) by stratified subgroup-adjusted analysis, patients with lowest quartile (Q1) Í33-positivity had no benefit from GO (relapse risk, HR 2.41 (1.27–4.56), P=0.009 for trend; overall survival, HR 1.52 (0.92–2.52)). However, from the dose randomisation (NCRI-AML17, n=464, CBF-AMLs included), 6 mg/m2 GO only had a relapse benefit without increased early mortality in CD33-low (Q1) patients (relapse risk HR 0.64 (0.36–1.12) versus 1.70 (0.99–2.92) for CD33-high, P=0.007 for trend). Thus CD33 expression is a predictive factor for GO effect in adult AML; although GO does not appear to benefit the non-CBF AML patients with lowest CD33 expression a higher GO dose may be more effective for CD33-low but not CD33-high younger adults

Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more mature CD34− AML have heterogeneous immunophenotypes overlapping with normal stem/progenitor cells (SPC) but may be differentiated by functional markers. We therefore investigated the oxidative/reactive oxygen species (ROS) profile, its relationship with cell-cycle/BCL2 for normal SPC, and whether altered in AML and myelodysplasia (MDS). In control BM (n = 24), ROS levels were highest in granulocyte-macrophage progenitors (GMP) and CD34− myeloid precursors but megakaryocyte-erythroid progenitors had equivalent levels to CD34+CD38low immature-SPC although they were ki67high. BCL2 upregulation was specific to GMPs. This profile was also observed for CD34+SPC in MDS-without-excess-blasts (MDS-noEB, n = 12). Erythroid CD34− precursors were, however, abnormally ROS-high in MDS-noEB, potentially linking oxidative stress to cell loss. In pre-treatment AML (n = 93) and MDS-with-excess-blasts (MDS-RAEB) (n = 14), immunophenotypic mature-SPC had similar ROS levels to co-existing immature-SPC. However ROS levels varied between AMLs; Flt3ITD+/NPM1wild-type CD34+SPC had higher ROS than NPM1mutated CD34+ or CD34− SPC. An aberrant ki67lowBCL2high immunophenotype was observed in CD34+AML (most prominent in Flt3ITD AMLs) but also in CD34− AMLs and MDS-RAEB, suggesting a shared redox/pro-survival adaptation. Some patients had BCL2 overexpression in CD34+ ROS-high as well as ROS-low fractions which may be indicative of poor early response to standard chemotherapy. Thus normal SPC subsets have distinct ROS, cell-cycle, BCL2 profiles that in AML /MDS-RAEB are decoupled from maturation. The combined profile of these functional properties in AML subpopulations may be relevant to differential treatment resistance