1,157 research outputs found
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Hanford Permanent Isolation Barrier Program: Asphalt technology development
An important component of the Hanford Permanent Isolation Barrier is the use of a two-layer composite asphalt system, which provides backup water diversion capabilities if the primary capillary barrier fails to meet infiltration goals. Because of asphalt`s potential to perform to specification over the 1000-year design life criterion, a composite asphalt barrier (HMAC/fluid-applied polymer-modified asphalt) is being considered as an alternative to the bentonite clay/high density poly(ethylene) barriers for the low-permeability component of the Hanford Permanent Isolation Barrier. The feasibility of using asphalt as a long-term barrier is currently being studied. Information that must be known is the ability of asphalt to retain desirable physical properties over a period of 1000 years. This paper presents the approach for performing accelerated aging tests and evaluating the performance of samples under accelerated conditions. The results of these tests will be compared with asphalt artifact analogs and the results of modeling the degradation of the selected asphalt composite to make life-cycle predictions
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Potential application of Madison formation waters for community heating in South Dakota
It is suggested that the most practical early application of the Madison waters is in community space heating with the local hot waters considered as a municipal commodity. The general design of such a community system is discussed along with its cost, means of financing, and life expectancy. Legal questions and state statutes that are pertinent are cited and the life expectancy of the entire Madison resource and equipment to expoit the resource are considered. (MHR
A comparison of statistical machine learning methods in heartbeat detection and classification
In health care, patients with heart problems require quick responsiveness in a clinical setting or in the operating theatre. Towards that end, automated classification of heartbeats is vital as some heartbeat irregularities are time consuming to detect. Therefore, analysis of electro-cardiogram (ECG) signals is an active area of research. The methods proposed in the literature depend on the structure of a heartbeat cycle. In this paper, we use interval and amplitude based features together with a few samples from the ECG signal as a feature vector. We studied a variety of classification algorithms focused especially on a type of arrhythmia known as the ventricular ectopic fibrillation (VEB). We compare the performance of the classifiers against algorithms proposed in the literature and make recommendations regarding features, sampling rate, and choice of the classifier to apply in a real-time clinical setting. The extensive study is based on the MIT-BIH arrhythmia database. Our main contribution is the evaluation of existing classifiers over a range sampling rates, recommendation of a detection methodology to employ in a practical setting, and extend the notion of a mixture of experts to a larger class of algorithms
Evaluation of analogues of furan-amidines as inhibitors of NQO2
Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluated. The furan ring has been changed to other heterocycles (imidazole, N-methylimidazole, oxazole, thiophene) and the amidine group has been replaced with imidate, reversed amidine, N-arylamide and amidoxime to probe NQO2 activity, improve solubility and decrease basicity of the lead furan amidine. All compounds were fully characterised spectroscopically and the structure of the unexpected product N-hydroxy-4-(5-methyl-4-phenylfuran-2-yl)benzamidine was established by X-ray crystallography. The analogues were evaluated for inhibition of NQO2, which showed lower activity than the lead furan amidine. The observed structure-activity relationship for the furan-amidine series with NQO2 was rationalized by preliminary molecular docking and binding mode analysis. In addition, the oxazole-amidine analogue inhibited the growth of Plasmodium falciparum with an IC50 value of 0.3 μM
Large-scale collective motion of RFGC galaxies in curved space-time
We consider large-scale collective motion of flat edge-on spiral galaxies
from the Revised Flat Galaxy Catalogue (RFGC) taking into account the curvature
of space-time in the Local Universe at the scale 100 Mpc/h. We analyse how the
relativistic model of collective motion should be modified to provide the best
possible values of parameters, the effects that impact these parameters and
ways to mitigate them. Evolution of galactic diameters, selection effects, and
difference between isophotal and angular diameter distances are inadequate to
explain this impact. At the same time, measurement error in HI line widths and
angular diameters can easily provide such an impact. This is illustrated in a
toy model, which allows analytical consideration, and then in the full model
using Monte Carlo simulations. The resulting velocity field is very close to
that provided by the non-relativistic model of motion. The obtained bulk flow
velocity is consistent with {\Lambda}CDM cosmology.Comment: 10 pages, 3 figures, 2 table
Modified gravity without dark matter
On an empirical level, the most successful alternative to dark matter in
bound gravitational systems is the modified Newtonian dynamics, or MOND,
proposed by Milgrom. Here I discuss the attempts to formulate MOND as a
modification of General Relativity. I begin with a summary of the
phenomenological successes of MOND and then discuss the various covariant
theories that have been proposed as a basis for the idea. I show why these
proposals have led inevitably to a multi-field theory. I describe in some
detail TeVeS, the tensor-vector-scalar theory proposed by Bekenstein, and
discuss its successes and shortcomings. This lecture is primarily pedagogical
and directed to those with some, but not a deep, background in General
RelativityComment: 28 pages, 10 figures, lecture given at Third Aegean Summer School,
The Invisible Universe: Dark Matter and Dark Energy, minor errors corrected,
references update
Review of progress in Fast Ignition
Copyright 2005 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Physics of Plasmas, 12(5), 057305, 2005 and may be found at http://dx.doi.org/10.1063/1.187124
Optical Spectra of SNR Candidates in NGC 300
We present moderate-resolution (<5A) long-slit optical spectra of 51 nebular
objects in the nearby Sculptor Group galaxy NGC 300 obtained with the 2.3 meter
Advanced Technology Telescope at Siding Spring Observatory, Australia. Adopting
the criterion of [SII]/Ha>=0.4 to confirm supernova remnants (SNRs) from
optical spectra, we find that of 28 objects previously proposed as SNRs from
optical observations, 22 meet this criterion with six showing [SII]/Ha of less
than 0.4. Of 27 objects suggested as SNRs from radio data, four are associated
with the 28 previously proposed SNRs. Of these four, three (included in the 22
above) meet the criterion. In all, 22 of the 51 nebular objects meet the
[SII]/Ha criterion as SNRs while the nature of the remaining 29 objects remains
undetermined by these observations.Comment: Accepted for publication in Astrophysics & Space Scienc
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