Classification and Lateralization of Temporal Lobe Epilepsies with and without Hippocampal Atrophy Based on Whole-Brain Automatic MRI Segmentation

Brain images contain information suitable for automatically sorting subjects into categories such as healthy controls and patients. We sought to identify morphometric criteria for distinguishing controls (n = 28) from patients with unilateral temporal lobe epilepsy (TLE), 60 with and 20 without hippocampal atrophy (TLE-HA and TLE-N, respectively), and for determining the presumed side of seizure onset. The framework employs multi-atlas segmentation to estimate the volumes of 83 brain structures. A kernel-based separability criterion was then used to identify structures whose volumes discriminate between the groups. Next, we applied support vector machines (SVM) to the selected set for classification on the basis of volumes. We also computed pairwise similarities between all subjects and used spectral analysis to convert these into per-subject features. SVM was again applied to these feature data. After training on a subgroup, all TLE-HA patients were correctly distinguished from controls, achieving an accuracy of 96 ± 2% in both classification schemes. For TLE-N patients, the accuracy was 86 ± 2% based on structural volumes and 91 ± 3% using spectral analysis. Structures discriminating between patients and controls were mainly localized ipsilaterally to the presumed seizure focus. For the TLE-HA group, they were mainly in the temporal lobe; for the TLE-N group they included orbitofrontal regions, as well as the ipsilateral substantia nigra. Correct lateralization of the presumed seizure onset zone was achieved using hippocampi and parahippocampal gyri in all TLE-HA patients using either classification scheme; in the TLE-N patients, lateralization was accurate based on structural volumes in 86 ± 4%, and in 94 ± 4% with the spectral analysis approach. Unilateral TLE has imaging features that can be identified automatically, even when they are invisible to human experts. Such morphometric image features may serve as classification and lateralization criteria. The technique also detects unsuspected distinguishing features like the substantia nigra, warranting further study

Intensity of tropical cyclones during pre and post monsoon seasons in relation to accumulated tropical heat potential over Bay of Bengal

The aim of the present study is to understand the impact of oceanic heat potential in relation to the intensity of tropical cyclones (TC) in the Bay of Bengal during the pre-monsoon (April–May) and post-monsoon (October–November) cyclones for the period 2006–2010. To accomplish this, the two-layer gravity model (TLGM) is employed to estimate daily tropical cyclone heat potential (TCHP) utilizing satellite altimeter data, satellite sea surface temperature (SST), and a high-resolution comprehensive ocean atlas developed for Indian Ocean, subsequently validated with in situ ARGO profiles. Accumulated TCHP (ATCHP) is estimated from genesis to the maximum intensity of cyclone in terms of minimum central pressure along their track of all the cyclones for the study period using TLGM generated TCHP and six-hourly National Centre for Environmental Prediction Climate Forecast System Reanalysis data. Similarly, accumulated sea surface heat content (ASSHC) is estimated using satellite SST. In this study, the relationship between ATCHP and ASSHC with the central pressure (CP) which is a function of TC intensity is developed. Results reveal a distinct relationship between ATCHP and CP during both the seasons. Interestingly, it is seen that requirement of higher ATCHP during pre-monsoon cyclones is required to attain higher intensity compared to post-monsoon cyclones. It is mainly attributed to the presence of thick barrier layer (BL) resulting in higher enthalpy fluxes during post-monsoon period, where as such BL is non-existent during pre-monsoon period

Tratamento do transtorno de pânico com terapia psicodramática de grupo Treatment for panic disorder with psychodramatic group therapy

INTRODUÇÃO/OBJETIVOS: Há poucos trabalhos publicados sobre psicoterapia grupal para pacientes com transtorno de pânico (TP); além disso, esses estudos geralmente são restritos a abordagens cognitivo-comportamentais. O objetivo deste trabalho é relatar uma experiência de atendimento psicoterápico psicodramático grupal para portadores de TP, iniciada em 1996 na Faculdade de Medicina de Botucatu/Unesp, e discutir aspectos psicodinâmicos desse transtorno. MÉTODOS: Atende-se uma média de oito a dez pacientes em sessões mensais de duas horas de duração, nas quais se utilizam técnicas psicodramáticas. O uso associado de psicofármacos é a regra. A temática é aberta, centrando-se tanto em aspectos próprios do TP (sintomas mais comuns; peregrinação em serviços médicos até o diagnóstico; preocupações hipocondríacas; limitações e dependência; reações dos familiares; estratégias de exposição e enfrentamento; efeitos e reações dos medicamentos) quanto em problemas individuais específicos. RESULTADOS: A abordagem psicodramática favorece a identificação e a elaboração de aspectos psicodinâmicos. Entre estes, destacaram-se os sentimentos de desamparo e seus desdobramentos: insegurança; fragilidade e medo; raiva e culpa; sentimentos de desamor e rejeição; vergonha e inferioridade; isolamento e dificuldade de pedir ajuda; dificuldade de identificar e de expressar sentimentos - manifestados somaticamente -; e dificuldade de assumir o papel de "cuidador" e outras responsabilidades. CONCLUSÕES: Aspectos valiosos para o tratamento do TP, como apoio mútuo, companheirismo, confiança, modelo e estímulo, são favorecidos pelo contexto grupal homogêneo. O compartilhar de experiências e sofrimentos comuns propiciou rápida coesão e suporte grupal, melhora da capacidade de expressar sentimentos e da auto-estima e o aprimoramento de papéis sociais. Além da melhora dos sintomas, possibilitou-se a melhor compreensão e elaboração destes, que passam a ser integrados significativamente no contexto existencial.<br>INTRODUCTION: There are few published articles on group psychotherapy for patients with panic disorder (PD) and usually they are restricted to the cognitive-behavioral approach. OBJECTIVE: To describe an experience of group psychodramatic therapy for PD patients, started in 1996 at Botucatu Medical School - UNESP, and discuss psychodynamic aspects of the panic disorder. METHODS: Two-hour monthly psychodramatic sessions, with an average of 8 to10 patients were carried out. The patients were usually receiving concomitantly psychopharmacological treatment. The subjects to be discussed were freely chosen, ranging from issues directly related to PD (most common symptoms, hurdles to get to a diagnosis, hypochondriac concerns, limitations and dependency, family reactions, strategies of exposure and coping, and effects of drug treatment) to individual conflicts and problems. RESULTS: The psychodramatic approach favors the identification and elaboration of psychodynamic aspects. The most common feelings observed were helplessness and other related ones, such as: insecurity; vulnerability and fear; anger and guilt; isolation and difficulty in identifying and expressing emotions (which manifested physically); and difficulty in assuming the role of caretaker and other responsibilities. CONCLUSIONS: Valuable aspects for the treatment of PD, such as mutual support, partnership, confidence, modeling and encouragement, are favored in a group setting, where sharing experiences and sufferings helped to improve the participants' self-esteem, their ability to express emotions and to play different social roles. Besides the clinical improvement, the symptoms could be better understood and elaborated, and meaningfully integrated into their life context