A community-engaged approach to investigate cardiovascular-associated inflammation among American Indian women: A research protocol

American Indian women are more likely to die from cardiovascular disease (CVD) than White or African American women. Inflammatory processes may underlie CVD disparities by gender and race and may be critical to understanding population-specific drivers and potential buffers. Exposure to environmental air pollutants, especially particulate matter (PM), is known to be an important catalyst in CVD-associated inflammation. Positive psychological states, associated with low levels of inflammatory gene expression, could serve to moderate the inflammatory response to environmental air pollutants and ultimately lead to better cardiovascular health outcomes. The aim of the ongoing community-engaged and NIH-funded study described in this study protocol is to address the racial and gender gaps in CVD mortality by investigating the contextually relevant and culturally important determinants of health among American Indian women. In this paper we describe the procedures used to examine the relationship between environmental air pollutant exposures (PM 10-2.5 and PM 2.5 ), psychological factors (e.g., depressive symptoms, posttraumatic stress symptoms, eudemonic well-being, and positive emotions), and cardiovascular-associated inflammation (hs-CRP, IL-6, Amyloid A, CBCs with differentials) in a sample of 150 women 18–50 years of age from the Lumbee Tribe in southeastern North Carolina. We describe lessons learned and strategies used in developing a community-engaged approach to enhance recruitment of American Indian women in biomedical research. The empirical data and community infrastructure resulting from this study will be foundational in designing and testing future interventions to reduce CVD-associated morbidity and mortality in American Indian women

Exploration of the equilibrium operating space for NSTX-Upgrade

This paper explores a range of high-performance equilibrium scenarios available in the NSTX-Upgrade device [J.E. Menard, submitted for publication to Nuclear Fusion]. NSTX-Upgrade is a substantial upgrade to the existing NSTX device [M. Ono, et al., Nuclear Fusion 40, 557 (2000)], with significantly higher toroidal field and solenoid capabilities, and three additional neutral beam sources with significantly larger current drive efficiency. Equilibria are computed with freeboundary TRANSP, allowing a self consistent calculation of the non-inductive current drive sources, the plasma equilibrium, and poloidal field coil current, using the realistic device geometry. The thermal profiles are taken from a variety of existing NSTX discharges, and different assumptions for the thermal confinement scalings are utilized. The no-wall and idealwall n=1 stability limits are computed with the DCON code. The central and minimum safety factors are quite sensitive to many parameters: they generally increases with large outer plasmawall gaps and higher density, but can have either trend with the confinement enhancement factor. In scenarios with strong central beam current drive, the inclusion of non-classical fast ion diffusion raises qmin, decreases the pressure peaking, and generally improves the global stability, at the expense of a reduction in the non-inductive current drive fraction; cases with less beam current drive are largely insensitive to additional fast ion diffusion. The non-inductive current level is quite sensitive to the underlying confinement and profile assumptions. For instance, for BT=1.0 T and Pinj=12.6 MW, the non-inductive current level varies from 875 kA with ITER-98y,2 thermal confinement scaling and narrow thermal profiles to 1325 kA for an ST specific scaling expression and broad profiles. This sensitivity should facilitate the determination of the correct scaling of transport with current and field to use for future fully non-inductive ST devices. Scenarios are presented which can be sustained for 8-10 seconds, or (20-30)τCR, at βN=3.8-4.5, facilitating, for instance, the study of disruption avoidance for very long pulse. Scenarios have been documented which can operate with βT~25% and equilibrated qmin>1. The value of qmin can be controlled at either fixed non-inductive fraction of 100% or fixed plasma current, by varying which beam sources are used, opening the possibility for feedback qmin control. In terms of quantities like collisionality, neutron emission, non-inductive fraction, or stored energy, these scenarios represent a significant performance extension compared to NSTX and other present spherical torii

An efficient low-degree RMST algorithm for VLSI/ULSI physical design

Abstract. Motivated by very/ultra large scale integrated circuit (VLSI/ULSI) physical design applications, we study the construction of rectilinear minimum spanning tree (RMST) with its maximum vertex degree as the constraint. Given a collection of n points in the plane, we firstly construct a graph named the bounded-degree neighborhood graph (BNG). Based on this framework, we propose an O(n log n) algorithm to construct a 4-BDRMST (RMST with maximum vertex degree ≤ 4). This is the first 4-BDRMST algorithm with such a complexity, and experimental results show that the algorithm is significantly faster than the existing 4-BDRMST algorithms.

The Additive Value of Positive Psychological Capital in Predicting Work Attitudes and Behaviors

Conventional wisdom over the years and recent research findings have supported the importance of positivity in the workplace. However, to date, empirical analysis has not demonstrated potential added value of recently emerging positive state-like constructs such as psychological capital over the more established positive traits in predicting work attitudes and behaviors. This study of a sample of employees (N=336) from a broad cross section of organizations and jobs found that their state-like psychological capital is positively related to desired extra-role organizational citizenship behaviors (OCBs) and negatively with undesired organizational cynicism, intentions to quit and counterproductive workplace behaviors. Except for individual OCBs, their psychological capital also predicted unique variance in the same attitudinal and behavioral outcomes beyond their demographics, core self-evaluation, and personality traits, and person-organization fit and person-job fit. The article concludes with implications these findings have for future research and practical application

POSITIVE ORGANIZATIONAL SCHOLARSHIP CONCEPT: AN OVERVIEW AND FUTURE STUDIES

Ver arquivo em anexo já que não consegui colar o texto aqui