Trends in levels of self-reported psychological distress among individuals who seek psychiatric services over eight years: a comparison between age groups in three population surveys in Stockholm County

BACKGROUND: Psychiatric service use has increased in Sweden and in other developed countries, particularly among young people. Possible explanations include lower threshold for help-seeking among young people, but evidence is scarce. METHODS: We analysed the 2002, 2006 and 2010 Stockholm public health surveys for changes in the mean level of psychological distress among adult users of psychiatric in- and outpatient services in four age groups: 18-24, 25-44, 45-64 and ≥65 years. Psychological distress was measured via the 12-item General Health Questionnaire (GHQ-12), using the Likert scoring method 0-1-2-3. In- and out-patient psychiatric service use within 6 months from the surveys was obtained from registers. RESULTS: The mean level of distress among young adults 18-24 years who utilize psychiatric services decreased between 2002 (mean GHQ-12 score, 95% confidence interval 20.5, 18.1-23.0) and 2010 (16.2, 14.6-17.7), while it remained fairly stable in older age groups. Results were similar in sex-stratified analyses, although the decrease was statistically significant only among young women 18-24 years. At the end of the follow-up, the level of distress among patients was similar for all age-groups. CONCLUSIONS: There were no differences between age groups in the level of distress when seeking care at the end of the follow-up period, supporting that there is no age-specific over- or under-consumption of psychiatric care in later years. However, the lowered threshold for help-seeking among young adults over time might have contributed to increases in psychiatric service use in the young age group. Public health policy and service delivery planning should consider the needs of the widening group of young users of psychiatric services

The gene expression landscape of breast cancer is shaped by tumor protein p53 status and epithelial-mesenchymal transition

Introduction: Gene expression data derived from clinical cancer specimens provide an opportunity to characterize cancer-specific transcriptional programs. Here, we present an analysis delineating a correlation-based gene expression landscape of breast cancer that identifies modules with strong associations to breast cancer-specific and general tumor biology. Methods: Modules of highly connected genes were extracted from a gene co-expression network that was constructed based on Pearson correlation, and module activities were then calculated using a pathway activity score. Functional annotations of modules were experimentally validated with an siRNA cell spot microarray system using the KPL-4 breast cancer cell line, and by using gene expression data from functional studies. Modules were derived using gene expression data representing 1,608 breast cancer samples and validated in data sets representing 971 independent breast cancer samples as well as 1,231 samples from other cancer forms. Results: The initial co-expression network analysis resulted in the characterization of eight tightly regulated gene modules. Cell cycle genes were divided into two transcriptional programs, and experimental validation using an siRNA screen showed different functional roles for these programs during proliferation. The division of the two programs was found to act as a marker for tumor protein p53 (TP53) gene status in luminal breast cancer, with the two programs being separated only in luminal tumors with functional p53 (encoded by TP53). Moreover, a module containing fibroblast and stroma-related genes was highly expressed in fibroblasts, but was also up-regulated by overexpression of epithelial-mesenchymal transition factors such as transforming growth factor beta 1 (TGF-beta1) and Snail in immortalized human mammary epithelial cells. Strikingly, the stroma transcriptional program related to less malignant tumors for luminal disease and aggressive lymph node positive disease among basal-like tumors. Conclusions: We have derived a robust gene expression landscape of breast cancer that reflects known subtypes as well as heterogeneity within these subtypes. By applying the modules to TP53-mutated samples we shed light on the biological consequences of non-functional p53 in otherwise low-proliferating luminal breast cancer. Furthermore, as in the case of the stroma module, we show that the biological and clinical interpretation of a set of co-regulated genes is subtype-dependent

Finite driving rate and anisotropy effects in landslide modeling

In order to characterize landslide frequency-size distributions and individuate hazard scenarios and their possible precursors, we investigate a cellular automaton where the effects of a finite driving rate and the anisotropy are taken into account. The model is able to reproduce observed features of landslide events, such as power-law distributions, as experimentally reported. We analyze the key role of the driving rate and show that, as it is increased, a crossover from power-law to non power-law behaviors occurs. Finally, a systematic investigation of the model on varying its anisotropy factors is performed and the full diagram of its dynamical behaviors is presented.Comment: 8 pages, 9 figure

A new test procedure to measure the soil-water characteristic curves using a small-scale centrifuge

ABSTRACT: The soil-water characteristic curve is conventionally measured using a pressure plate apparatus or a Tempe cell. Considerably long periods of time are required to measure the soil-water characteristic curves using the conventional equipment. A new test procedure is proposed, using a small-scale medical centrifuge to measure the soil-water characteristic curves for compacted, fine-grained soil specimens. Soil specimen holders were designed for the small-scale centrifuge. The soil-water characteristic curves of statically compacted specimens for three different fine-grained soils with varying percentages of clay were measured using the centrifuge for a suction range between 0 to 500 kPa. There is good comparison between the soil-water characteristic curves measured using the small-scale centrifuge and the conventional laboratory equipment. The results of this study are encouraging as soil-water characteristic curves can be measured in a shorter period of time, resulting in considerable savings

Evaluating the Ability of Swell Prediction Models to Predict the Swell Behavior of Excessively High Plastic Soils

Lightly loaded structures underneath expansive soils encounter severe damage due to the swell/shrink nature of expansive soils resulting from moisture variations. Billions of dollars are spent every year to repair the damages caused by these soils in the U.S. and worldwide. Designing structures to accommodate the swelling strains is a major challenge as predicting the swelling potential of these soils accurately is not easy. A wide variety of swell prediction models have been introduced by various researchers to predict the behavior of these often-problematic expansive soils. These models include various properties of soils such as, plasticity characteristics, compaction conditions, consolidation characteristics, moisture content variations, matric suction, and clay mineralogical characteristics. However, these models are generally developed with typical moderate to high plastic soils in mind whose plasticity indices range from 25 to 45. Their applicability to soils that have liquid limits in the order of 200% is not well understood. In this paper, the ability of these models to predict the behavior of excessively high plastic soils with plasticity indices ranging from 45 to 85 were evaluated. For this purpose, four existing analytical prediction models that use combinations of above-mentioned properties were selected and used to predict the one-dimensional and three-dimensional swelling strains on three high swelling soils. These predictions were verified by conducting one-dimensional and three-dimensional swell tests on the three soil types. The swell tests were conducted at three different initial moisture contents to observe how well the models could predict different levels of moisture absorption. The ability of each of the four selected methods in predicting both 1D and 3D swell strains was discussed and their relative merits and demerits are highlighted. In addition, finite element modeling was performed to simulate one-dimensional and three-dimensional swell tests by using material models that use volumetric and suction changes with moisture contents to simulate expansive soil behavior within the finite element model. The results indicated that while the analytical prediction models gave reasonable results the finite element analysis predicted results were closest to the laboratory measure soils in case both 1D and 3D analyses. Among other analytical models the ones that incorporated mineralogical and suction data exhibited better results

What are the methodological characteristics of evidence and gap maps? A systematic review and evidence and gap map

This is the final version. Available from Wiley via the DOI in this record. Data availability statement. The data that support this findings of this study are available from the corresponding author upon reasonable request.Introduction - Clarity on the characteristics of methods used to produce evidence and gap maps (EGMs) will highlight areas where method development is needed to ensure these increasingly produced tools are made following best practice to assure their quality and utility. This paper aims to describe the range, nature and variability of key methodological characteristics of studies publishing EGMs. Methods - We followed a protocol, written a‐prior and informed by PRISMA and MECCIR guidelines for undertaking systematic reviews. We searched nine data bases, from 2010, for studies across any discipline that included details of their methods used to produce an EGM. Search results were screened by two reviewers independently and the subsequent data was extracted and managed according to predefined criteria. We mapped these together with the year of publication and the area of research as the two primary dimensions. We followed established methods for mapping the evidence, including the process of developing the map framework and the filters for our interactive map. We sought input and involvement from stakeholders during this process. Results - We found 145 studies from nine distinct research areas, with health research accounting for 67%. There were 11 map designs found, of these bubble plots were the most common design, before 2019, since then it has been a matrix map design. Stakeholders were involved in 47.7% of studies, 48.35% of studies stated finding gaps was an aim of their work, 42% reported publishing or registering a protocol and only 9.39% of studies mentioned a plan to update their evidence maps/EGMs. Discussion/Conclusion - Key areas of methodological development relate to: the involvement of stakeholders, the conceptualization of gaps and the practices for updating maps. The issues of ambiguity in terminology, the flexibility of visualizations of the data and the lack of reporting detail were other aspects that needs further consideration in studies producing an EGM.National Institute for Health Research Applied Research Collaboration South West Peninsul

Task shifting and integration of HIV care into primary care in South Africa: The development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention

Background: Task shifting and the integration of human immunodeficiency virus (HIV) care into primary care services have been identified as possible strategies for improving access to antiretroviral treatment (ART). This paper describes the development and content of an intervention involving these two strategies, as part of the Streamlining Tasks and Roles to Expand Treatment and Care for HIV (STRETCH) pragmatic randomised controlled trial. Methods: Developing the intervention: The intervention was developed following discussions with senior management, clinicians, and clinic staff. These discussions revealed that the establishment of separate antiretroviral treatment services for HIV had resulted in problems in accessing care due to the large number of patients at ART clinics. The intervention developed therefore combined the shifting from doctors to nurses of prescriptions of antiretrovirals (ARVs) for uncomplicated patients and the stepwise integration of HIV care into primary care services. Results: Components of the intervention: The intervention consisted of regulatory changes, training, and guidelines to support nurse ART prescription, local management teams, an implementation toolkit, and a flexible, phased introduction. Nurse supervisors were equipped to train intervention clinic nurses in ART prescription using outreach education and an integrated primary care guideline. Management teams were set up and a STRETCH coordinator was appointed to oversee the implementation process. Discussion: Three important processes were used in developing and implementing this intervention: active participation of clinic staff and local and provincial management, educational outreach to train nurses in intervention sites, and an external facilitator to support all stages of the intervention rollout