Revisão narrativa: realização da biópsia com coloração do linfonodo sentinela e sua utilidade para detecção de linfonodos axilares tumorais no câncer de mama

O câncer de mama é uma doença maligna causada pela proliferação anormal de células da mama, sendo o tumor mais frequente em mulheres, com incidência aproximada de 1.000.000 de casos novos a cada ano no mundo, é causador de diversos óbitos em mulheres adultas, tornando-se um grande problema de saúde pública no Brasil e no mundo devido às elevadas taxas de morbi-mortalidade. Existem diferentes formas de tratamento empregadas atualmente para o câncer de mama, onde a principal delas é a quimioterapia neoadjuvante, que se mostrou mais eficaz. As terapias sistêmicas adjuvantes também auxiliam na recorrência de neoplasia, contudo é inerente o impacto da doença e seu tratamento na saúde mental e física das pacientes, sendo favorável o diagnóstico precoce e assertivo. Metodologia: Revisão narrativa baseada na pergunta norteadora “utilidade da biópsia de linfonodo sentinela e suas colorações para o diagnóstico de câncer de mama”. Utilizado bases de dados Scielo e PubMed, com o auxílio de Docs/BVS aplicou-se os seguintes descritores em saúde: Sentinel Lymph Node and Breast Cancer, correspondentes em língua portuguesa (Linfonodo Sentinela e Câncer de Mama). Resultados e discussão: Dentre os corantes analisados, destacamos a indocianina verde (IGG) possui alta taxa de detecção, custo acessível e menor taxa de efeitos colaterais, juntamente com o uso da indocianina verde (ICG) para combinação com colóide tecnécio (Tc99m), pois foi visto que a utilização da detecção dupla evidenciou maior número de resultados positivos para linfonodos sentinela com metástase, o que diminui a ocorrência de falsos negativos. Ademais, outro estudo avaliou o benefício do uso da fluorescência do corante indocianina verde (ICG) para combinação com colóide tecnécio (Tc99m) Conclusão: Conforme analisado, ICG e MB apresentaram grande relevância por serem baratos e de alta qualidade, 99mTc-Rituximabe é melhor que o fTcSC, indocianina verde (ICG) é seguro e de baixo custo, podendo até substituir o Tc99m pois não favorecer o potencial de radiação. Traçador duplo Tc99 e ICG apresentam melhores resultados combinados do que o Tc 99m sozinho

Núcleos de Ensino da Unesp: artigos 2007

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data