4,630 research outputs found
Materials Science Research Rack Onboard the International Space Station
The Materials Science Research Rack (MSRR) is a highly automated facility developed in a joint venture/partnership between NASA and ESA center dot Allows for the study of a variety of materials including metals, ceramics, semiconductor crystals, and glasses onboard the International Space Station (ISS) center dot Multi-user facility for high temperature materials science research center dot Launched on STS-128 in August 2009, and is currently installed in the U.S. Destiny Laboratory Module Research goals center dot Provide means of studying materials processing in space to develop a better understanding of the chemical and physical mechanisms involved center dot Benefit materials science research via the microgravity environment of space where the researcher can better isolate the effects of gravity during solidification on the properties of materials center dot Use the knowledge gained from experiments to make reliable predictions about conditions required on Earth to achieve improved material
The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1
The pseudophosphatase MK-STYX (mitogen-activated protein kinase phosphoserine/threonine/tyrosine-binding protein) has been implicated in the stress response pathway. The expression of MK-STYX inhibits the assembly of stress granules, which are cytoplasmic storage sites for mRNA that form as a protective mechanism against stressors such as heat shock, UV irradiation and hypoxia. Furthermore, MK-STYX interacts with a key component of stress granules: G3BP-1 (Ras-GTPase activating protein SH3 domain binding protein-1). Because G3BP-1 dephosphorylation at Ser149 induces stress granule assembly, we initially hypothesized that the inhibition of stress granules by MK-STYX was G3BP-1 phosphorylation-dependent. However, in the present study, using MK-STYX constructs and G3BP-1 phosphomimetic or nonphosphorylatable mutants, we show that MK-STYX inhibits stress granule formation independently of G3BP-1 phosphorylation at Ser149. The introduction of point mutations at the active site of MK-STYX that convert serine and phenylalanine to histidine and cysteine, respectively, is sufficient to generate an active enzyme. In separate experiments, we show that this active mutant, MK-STYXactive, has opposite effects to wild-type MK-STYK. Not only does MK-STYXactive induce stress granules, but also it has the capacity to dephosphorylate G3BP-1. Taken together, these results provide evidence that the pseudophosphatase MK-STYX plays a key role in the cellular response to stress
Investigating the veracity of self-reported post-traumatic growth: a profile analysis approach
Research into posttraumatic growth—positive psychological change that people report in their relationships, priorities in life, and self-perception after experiences of adversity—has been severely critiqued. We investigated the degree to which community members’ friends and relatives corroborated targets’ self-perceived positive and negative changes as measured by the Posttraumatic Growth Inventory-42. We found corroboration only for negative changes when we examined overall (averaged) scores. However, using a profile analysis procedure, we found significant participant–informant agreement on the domains of change that had relatively higher scores in the target’s profile and those that had relatively lower scores. Our results demonstrate that informants were able to observe that targets had changed and were sensitive to the idiosyncratic ways in which these changes had manifested in targets’ behavior
Evolution of Local Microstructures (ELMS): Spatial Instabilities of Coarsening
This work examines the diffusional growth of discrete phase particles dispersed within a matrix. Engineering materials are microstructurally heterogeneous, and the details of the microstructure determine how well that material performs in a given application. Critical to the development of designing multiphase microstructures with long-term stability is the process of Ostwald ripening. Ripening, or phase coarsening, is a diffusion-limited process which arises in polydisperse multiphase materials. Growth and dissolution occur because fluxes of solute, driven by chemical potential gradients at the interfaces of the dispersed phase material, depend on particle size. The kinetics of these processes are "competitive," dictating that larger particles grow at the expense of smaller ones, overall leading to an increase of the average particle size. The classical treatment of phase coarsening was done by Todes, Lifshitz, and Slyozov, (TLS) in the limit of zero volume fraction, V(sub v), of the dispersed phase. Since the publication of TLS theory there have been numerous investigations, many of which sought to describe the kinetic scaling behavior over a range of volume fractions. Some studies in the literature report that the relative increase in coarsening rate at low (but not zero) volume fractions compared to that / 2 1/ 3 predicted by TLS is proportional to V(sub v)(exp 1/2), whereas others suggest V(sub v)(exp 1/3). This issue has been resolved recently by simulation studies at low volume fractions in three dimensions by members of the Rensselaer/MSFC team
Long-term effectiveness of PROMPT treatment in a severely apractic-aphasic speaker
This study examined the acquisition and long-term maintenance of a functional core vocabulary by a severely apractic-aphasic speaker following the application of Prompts for Restructuring Oral Muscular Phonetic Targets (PROMPT) treatment. The subject was a 24-year-old male who had suffered a single left- hemisphere thrombotic CVA approximately 2 years prior to the beginning of this investigation. Treatment and maintenance were monitored over a 41-week period. The results showed that the 30 target words and phrases were produced accurately during the treatment phases of the study and after treatment was discontinued
The Quiet-Sun Photosphere and Chromosphere
The overall structure and the fine structure of the solar photosphere outside
active regions are largely understood, except possibly important roles of a
turbulent near-surface dynamo at its bottom, internal gravity waves at its top,
and small-scale vorticity. Classical 1D static radiation-escape modelling has
been replaced by 3D time-dependent MHD simulations that come closer to reality.
The solar chromosphere, in contrast, remains ill-understood although its
pivotal role in coronal mass and energy loading makes it a principal research
area. Its fine structure defines its overall structure, so that hard-to-observe
and hard-to-model small-scale dynamical processes are the key to understanding.
However, both chromospheric observation and chromospheric simulation presently
mature towards the required sophistication. The open-field features seem of
greater interest than the easier-to-see closed-field features.Comment: Accepted for special issue "Astrophysical Processes on the Sun" of
Phil. Trans. Royal Soc. A, ed. C. Parnell. Note: clicking on the year in a
citation opens the corresponding ADS abstract page in the browse
Mechanism of Action of Nerve Growth Factor and Cyclic AMP on Neurite Outgrowth in Embryonic Chick Sensory Ganglia: Demonstration of Independent Pathways of Stimulation
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Measuring the Hidden Aspects of Solar Magnetism
2008 marks the 100th anniversary of the discovery of astrophysical magnetic
fields, when George Ellery Hale recorded the Zeeman splitting of spectral lines
in sunspots. With the introduction of Babcock's photoelectric magnetograph it
soon became clear that the Sun's magnetic field outside sunspots is extremely
structured. The field strengths that were measured were found to get larger
when the spatial resolution was improved. It was therefore necessary to come up
with methods to go beyond the spatial resolution limit and diagnose the
intrinsic magnetic-field properties without dependence on the quality of the
telescope used. The line-ratio technique that was developed in the early 1970s
revealed a picture where most flux that we see in magnetograms originates in
highly bundled, kG fields with a tiny volume filling factor. This led to
interpretations in terms of discrete, strong-field magnetic flux tubes embedded
in a rather field-free medium, and a whole industry of flux tube models at
increasing levels of sophistication. This magnetic-field paradigm has now been
shattered with the advent of high-precision imaging polarimeters that allow us
to apply the so-called "Second Solar Spectrum" to diagnose aspects of solar
magnetism that have been hidden to Zeeman diagnostics. It is found that the
bulk of the photospheric volume is seething with intermediately strong, tangled
fields. In the new paradigm the field behaves like a fractal with a high degree
of self-similarity, spanning about 8 orders of magnitude in scale size, down to
scales of order 10 m.Comment: To appear in "Magnetic Coupling between the Interior and the
Atmosphere of the Sun", eds. S.S. Hasan and R.J. Rutten, Astrophysics and
Space Science Proceedings, Springer-Verlag, Heidelberg, Berlin, 200
Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy: criteria for weaning from ventricular assist devices
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