497 research outputs found

    Wire Bonding Challenges in Optoelectronics Packaging

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    Wire bonding has been used in integrated circuit (IC) packaging for many years. However, there are many challenges in wire bonding for optoelectronics packaging. These challenges include bonding on sensitive devices, bonding over cavity, bonding over cantilevel leads and bonding temperature limitations. The optoelectronics package design brings another challenge, which requires wire bonding to have deep access capability. In this paper, the wire bonding technologies are reviewed and ball bonding and wedge bonding are compared. The variables that affect the wire bonding process are then discussed. Finally, the challenges of wire bonding in optoelectronics packaging are presented in detail

    Let them eat cake!

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    Let them eat cake!' is a food-led event serving an edible imaginary of a Facebook profile. In early 2012, Facebook conducted massive scale emotional contagion by manipulating the emotional expressions in the News Feeds of 689,003 users. This exemplifies how the governability and the biopolitics of everyday life flow through the many layers of shared images, liked videos, protocols, and hyperlinks, all orchestrated by the Facebook News Feed algorithm. 'Let them eat cake!' proposes a gustatory experience to the visitor, a cake imagined with synthetic DNA encoded from a user's Facebook profile data. The profile's data categories (Ad Topics, Facial Recognition Data, Friends, Followers, Likes, and Political Views) are transposed into cake layers, with an absurd twist that reflects the algorithms agency. Ultimately the work explores innovative forms of engagement with complex socio-technical assemblages

    Collaborations Nord-Sud, TICs et bibliothèques

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    Co-organisée par la BM de Bordeaux-Mériadeck en collaboration avec l’IUT Michel de Montaigne- Bordeaux 3 (pôle Métiers du livre), l’Agence régionale pour l’écrit et le livre en Aquitaine (Arpel), et l’Agence de médiation culturelle des pays du Sahel, cette journée visait à présenter des exemples de collaboration entre bibliothèques ou institutions éducatives

    Lithospheric mantle evolution monitored by overlapping large igneous provinces: case study in southern Africa

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    Most of the studies on the large igneous provinces (LIPs) focus on Phanerozoic times, and in particular, thoserelated to the disruption of Pangea (e.g. CAMP, Karoo, Parana–Etendeka) while Precambrian LIPs (e.g.Ventersdorpf, Fortescue) remain less studied. Although the investigation of Precambrian LIPs is difficultbecause they are relatively poorly preserved, assessment of their geochemical characteristics in parallel withyounger overlapping LIP is fundamental for monitoring the evolution of the mantle composition through time.Recent 40Ar/39Ar dating of the Okavango giant dyke swarm (and related sills) in southern Africa showed that~90% of the dykes were emplaced at 179±1Ma and belong to the Karoo large igneous province whereas ~10% ofdykes yielded Proterozoic ages (~1–1.1 Ga). Here,weprovide newmajor, trace and rare earth elements analysesof the low-Ti Proterozoic Okavango dyke swarm (PODS) that suggest, combined with age data, a cognate originwith the 1.1 Ga Umkondo large igneous province (UIP), southern Africa.The geochemical characteristics of the PODS and UIP basalts are comparable to those of overlapping low-TiKaroo basalts, and suggest that both LIPs were derived from similar enriched mantle sources. A mantle plumeorigin for these LIPs is not easily reconciled with the geochemical dataset and the coincidence of twocompositionally similar mantle plumes acting 900 Myr apart is unlikely. Instead,we propose that the Umkondoand Karoo large igneous provinces monitored the slight evolution of a shallow enriched lithospheric mantlefrom Proterozoic to Jurassic

    Annual report 2021

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    The Insurance Fraud Division of the South Carolina Insurance Department provides statistics and information about insurance fraud cases

    ARTICLE Development of a Polishing Step Using a Hydrophobic Interaction Membrane Adsorber With a PER.C6 1 -Derived Recombinant Antibody

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    ABSTRACT: Membrane chromatography has already proven to be a powerful alternative to polishing columns in flowthrough mode for contaminant removal. As flow-through utilization has expanded, membrane chromatography applications have included the capturing of large molecules, including proteins such as IgGs. Such bind-and-elute applications imply the demand for high binding capacity and larger membrane surface areas as compared to flow-through applications. Given these considerations, a new Sartobind Phenyl TM membrane adsorber was developed for large-scale purification of biomolecules based on hydrophobic interaction chromatography (HIC) principles. The new hydrophobic membrane adsorber combines the advantages of membrane chromatography-virtually no diffusion limitation and shorter processing time-with high binding capacity for proteins comparable to that of conventional HIC resins as well as excellent resolution. Results from these studies confirmed the capability of HIC membrane adsorber to purify therapeutic proteins with high dynamic binding capacities in the range of 20 mg-MAb/cm 3 -membrane and excellent impurity reduction. In addition the HIC phenyl membrane adsorber can operate at five-to ten-fold lower residence time when compared to column chromatography. A bind/elute purification step using the HIC membrane adsorber was developed for a recombinant monoclonal antibody produced using the PER.C6 1 cell line. Loading and elution conditions were optimized using statistical design of experiments. Scaleup is further discussed, and the performance of the membrane adsorber is compared to a traditional HIC resin used in column chromatography
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