ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure

The majority of genes contributing to the heritable component of blood pressure remain unidentified, but there is substantial evidence to suggest that common polymorphisms at loci involved in the biosynthesis of the corticosteroids aldosterone and cortisol are important. This view is supported by data from genome-wide association studies that consistently link the CYP17A1 locus to blood pressure. In this review article, we describe common polymorphisms at three steroidogenic loci (CYP11B2, CYP11B1 and CYP17A1) that alter gene transcription efficiency and levels of key steroids, including aldosterone. However, the mechanism by which this occurs remains unclear. While the renin angiotensin system is rightly regarded as the major driver of aldosterone secretion, there is increasing evidence that the contribution of corticotropin (ACTH) is also significant. In light of this, we propose that the differential response of variant CYP11B2, CYP11B1 and CYP17A1 genes to ACTH is an important determinant of blood pressure, tending to predispose individuals with an unfavourable genotype to hypertension

Epistemologies of Imperial Feminism(s): Violence, Colonization, and Sexual (Re)Inscriptions of Empire.

This doctoral thesis project brings together Indigenous theory and post-colonial feminism under a decolonial framework to highlight the significance of feminist moral epistemologies in establishing global hierarchical systems. I argue that when situated within the sexual matrices of coloniality, feminist moral regulation knowledge production in Canada institutionalizes hierarchical social ordering through the de-mediation of non-secular agency and sacred Indigenous self-consciousness. This dissertation warns feminist moral regulation scholars of the contamination of feminist knowledge produced about the “sexual Other” that remains colonized within the methodological grids of the epistemic structures of secular-coloniality. It highlights how a focus on epistemology allows us to understand the role of feminism’s contingent investments in imperial knowledge systems and the effects this has for structuring neocolonial governmentality and settler colonial domination, in the service of sexual empire. In it, I employ deconstruction and genealogical analytics to reveal how structures of empire are intertwined with discourses of sex and colonial law to trace how such intertwinements shape the production of subjectivities, liberal state-making projects, and colonial enterprises under the promise of “sexual progress” and political freedom. This framework allows me to explore the co-production of knowledge systems within neocolonial orders by focusing on philosophical debates about human rights, gender and racial (in)security, liberal secularism, transnational imperial feminist power. Central to the argument that I pursue in this dissertation is that in the wake of neo-liberalism and neo-colonialism, feminist knowledge about sex work and morality is not mediated by a singular site of annunciation via moral regulation theory. I argue, instead, that moral regulation feminist theorizations of sexual morality are also conditioned by the epistemic and methodological project of imperial feminist praxis. Therefore, this dissertation investigates the epistemological dimensions of moral regulation feminist knowledge production and excavates the modalities of power that drive this discipline and explores the epistemological regions from which it speaks.