Proposal for an optical laser producing light at half the Josephson frequency

We describe a superconducting device capable of producing laser light in the visible range at half of the Josephson generation frequency with the optical phase of the light locked to the superconducting phase difference. It consists of two single-level quantum dots embedded into a p-n semiconducting heterostructure and surrounded by a cavity supporting a resonant optical mode. We study decoherence and spontaneous switching in the device.Comment: 4+3 pages, 3+1 figure

Reproducción humana asistida : los problemas que suscita desde la bioética y el derecho

El artículo trata de los problemas éticos y jurídicos que surgen a raíz de la puesta en práctica de técnicas de reproducción asistida, al querer determinar la paternidad o poder elegir el sexo de un embrión viable, entre otros.The article deals with the ethical and juridical problems derived from the implementation of assisted reproduction techniques in determining paternity a the sex of au embryo, among other questions

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Lasing at half the Josephson frequency with exponentially long coherence times

We describe a superconducting device capable of producing laser light in the visible range at half the Josephson generation frequency, with the optical phase of the light locked to the superconducting phase difference. An earlier proposed device, the so-called “half-Josephson laser” [ Phys. Rev. Lett. 107 073901 (2011)], cannot provide long coherence times, because of spontaneous switchings between the emitter states. To circumvent this we consider N?1 emitters driving an optical resonator mode. We derive a general model that captures essential physics of such devices while not depending on specific microscopic details. We find the conditions under which the coherence times are exponentially long, thus surpassing the fundamental limitation on the coherence times of common lasers. For this we study the noise in the device. In particular, we are interested in the rate of large fluctuations of the light field in the limit where the typical fluctuations are small. The large fluctuations are responsible for switching of the laser between stable states of radiation and therefore determine the coherence time.QN/Quantum NanoscienceApplied Science