Should Europe Further Strengthen Intellectual Property for Plant Breeders? An Analysis of Seed Industry Proposals

This paper illustrates the potential negative effects of increasing the scope of plant breeders' rights (PBR) protection, as has been proposed for Europe by leading plant breeding firms. Such a policy could increase the costs for varietal development for breeding companies, particularly if their access to varieties of the market leader is constrained. This is represented as an asymmetrical increase in breeders' cost functions in a simple model of endogenous quality choice under price competition. Increased scope of IPR protection leads to increased profits for the leading breeding company but decreases in varietal quality and both farm and overall profits.intellectual property rights, product differentiation, plant breeding, genetic diversity, Research and Development/Tech Change/Emerging Technologies, L13, O34, Q16,

The Person at the Core of Psychological Science

The paper has been written from aphilosophical perspective and triggered by the recurrent discussions in psychology about the most suitable methods to study our multifaceted subjectivity. Its main point is that aphenomenological understanding of the human person provides arobust and also flexible philosophical framework for psychology. The first part discusses three classical distinctions –individual/general; explaining/understanding; induction/interpretation– which, in spite of possible deficiencies, are useful to illustrate the specificity of the human sciences relative to the natural sciences. If not understood as an either-or dichotomy these distinctions represent the search of the right balance to reflect the complexity and richness of psychological science. The second part presents the phenomenological notions of ‘vital reduction’ and ‘personalist reduction’, where reductions does not take on an eliminativistic meaning, but of directing the mind’s gaze to attend to what is originally the case. The ‘vital reduction’ reveals asubject of experience at the center of the lifeworld, and the ‘personalist reduction’ sees in rationality –i.e., the power to grasp the meaning of things and to recognize other subjects of experience –adeeper dimension of the subject, who we can thus call aperson. Psychology and phenomenology converge in disclosing the person-centeredness of our lifeworld

The unified coordination language UnCL.

In this paper we show how to use a (subset) of UML as an Unified Coordination Language (UnCL) that is based on a separation of concerns between coordination and computation. As such UnCL provides a general language for the coordination of, in particular, object-oriented applications. The basic idea of UnCL is to use UML as a formalism to specify the `glue code' in terms of state-machines which are added to the classes of the underlying applications. These state-machines describe the coordination of the objects of the underlying applications in terms of sending and receiving events. We introduce a formal semantics of UnCL and discuss its implementation using a new tool for the transformation of XML data which is based on a new Rule Markup Language (RML). Finally, we discuss the incorporation of a more high-level coordination mechanism called MoCha, an exogenous coordination framework for (distributed) communication and collaboration using mobile channels as its mediu

Mesons as qbar-q Bound States from Euclidean 2-Point Correlators in the Bethe-Salpeter Approach

We investigate the 2-point correlation function for the vector current. The gluons provide dressings for both the quark self energy as well as the vector vertex function, which are described consistently by the rainbow Dyson-Schwinger equation and the inhomogeneous ladder Bethe-Salpeter equation. The form of the gluon propagator at low momenta is modeled by a 2-parameter ansatz fitting the weak pion decay constant. The quarks are confined in the sense that the quark propagator does not have a pole at timelike momenta. We determine the ground state mass in the vector channel from the Euclidean time Fourier transform of the correlator, which has an exponential falloff at large times. The ground state mass lies around 590 MeV and is almost independent of the model form for the gluon propagator. This method allows us to stay in Euclidean space and to avoid analytic continuation of the quark or gluon propagators into the timelike region.Comment: 21 pages (REVTEX), 8 Postscript figure

Enterprise Architecture Analysis with XML

This paper shows how XML can be used for static and dynamic analysis of architectures. Our analysis is based on the distinction between symbolic and semantic models of architectures. The core of a symbolic model consists of its signature that specifies symbolically its structural elements and their relationships. A semantic model is defined as a formal interpretation of the symbolic model. This provides a formal approach to the design of architectural description languages and a general mathematical foundation for the use of formal methods in enterprise architectures. For dynamic analysis we define transformations of models of architectures, modeled in XML, and for this purpose the XML vocabulary for an architecture is extended with a few constructs defined in the Rule Markup Language (RML). There are RML tools available that perform the desired transformations. 1. Introductio

Higgs sector and R-parity breaking couplings in models with broken U(1)_B-L gauge symmetry

Four different supersymmetric models based on SU(2)_L X U(1)_R X U(1)_B-L and SU(2)_L X SU(2)_R X U(1)_B-L gauge symmetry groups are studied. U(1)_B-L symmetry is broken spontaneously by a vacuum expectation value (VEV) of a sneutrino field. The right-handed gauge bosons may obtain their mass solely by sneutrino VEV. The physical charged lepton and neutrino are mixtures of gauginos, higgsinos and lepton interaction eigenstates. Explicit formulae for masses and mixings in the physical lepton fields are found. The spontaneous symmetry breaking mechanism fixes the trilinear R-parity breaking couplings. Only some special R-parity breaking trilinear couplings are allowed. There is a potentially large trilinear lepton number breaking coupling - which is unique to left-right models - that is proportional to the SU(2)_R gauge coupling g_R. The couplings are parametrized by few mixing angles, making the spontaneous R-parity breaking a natural ``unification framework'' for R-parity breaking couplings in SUSYLR models.Comment: 19 pages, no figures, uses REVTeX. To be published in PR

b -> s gamma in the left-right supersymmetric model

The rare decay $b \to s \gamma$ is studied in the left-right supersymmetric model. We give explicit expressions for all the amplitudes associated with the supersymmetric contributions coming from gluinos, charginos and neutralinos in the model to one-loop level. The branching ratio is enhanced significantly compared to the standard model and minimal supersymmetric standard model values by contributions from the right-handed gaugino and squark sector. We give numerical results coming from the leading order contributions. If the only source of flavor violation comes from the CKM matrix, we constrain the scalar fermion-gaugino sector. If intergenerational mixings are allowed in the squark mass matrix, we constrain such supersymmetric sources of flavor violation. The decay $b \to s \gamma$ sets constraints on the parameters of the model and provides distinguishing signs from other supersymmetric scenarios.Comment: 12 figure

Identification of occult metastases of medullary thyroid carcinoma by pentagastrin-stimulated intravenous calcitonin sampling followed by targeted surgery

BACKGROUND: High calcitonin (CT) serum levels suggest metastatic spread in medullary thyroid carcinoma (MTC) after thyroidectomy. In limited disease stages, however, morphological investigations including ultrasound, magnetic resonance imaging (MRI) and 18F-FDG positron emission tomography ([18F]FDG-PET) may often fail to identify exact tumour sites. OBJECTIVE: The aim of the present study was to establish an improved strategy to identify small cervical tumours by combining pentagastrin stimulation with bilateral cervical intravenous CT sampling followed by high-resolution ultrasound. DESIGN AND PATIENTS: Six MTC patients were examined, of whom five patients already had bilateral neck dissection. Five patients had sporadic MTC, and one patient suffered from MEN2a. RESULTS: Retrospective analysis of all patients revealed a highly sensitive positive correlation between an early calcitonin peak (20–40 s after pentagastrin injection) and site of cervical tumour affection. Postinterventional ultrasound examination of the affected regions of the neck revealed suspicious presence; in some cases small lymph nodes of less than 1 cm in size were then surgically excised. On histology, small tumours could be identified in four patients. Postsurgical examination revealed a clear decline of basal serum calcitonin levels in four patients (between −41% and −100%). In two patients CT normalized to baseline levels (< 10 pg/ml) and in another two patients CT rendered to near normal (14 and 17 pg/ml). CONCLUSION: Pentagastrin stimulation-based intravenous catheter sampling may be beneficial in the diagnostic work-up of MTC after thyroidectomy. Our data show that an early calcitonin peak (20–40 s after administration of pentagastrin) helps to identify tumour-affected regions

Sterols sense swelling in lipid bilayers

In the mimetic membrane system of phosphatidylcholine bilayers, thickening (pre-critical behavior, anomalous swelling) of the bilayers is observed, in the vicinity of the main transition, which is non-linear with temperature. The sterols cholesterol and androsten are used as sensors in a time-resolved simultaneous small- and wide angle x-ray diffraction study to investigate the cause of the thickening. We observe precritical behavior in the pure lipid system, as well as with sterol concentrations less than 15%. To describe the precritical behavior we introduce a theory of precritical phenomena.The good temperature resolution of the data shows that a theory of the influence of fluctuations needs modification. The main cause of the critical behavior appears to be a changing hydration of the bilayer.Comment: 11 pages, 7 ps figures included, to appear in Phys.Rev.

A factor IX variant that functions independently of factor VIII mitigates the hemophilia A phenotype in patient plasma

BackgroundRecombinant factor (F)IX-FIAV has previously been shown to function independently of activated FVIII (FVIIIa) and ameliorate the hemophilia A (HA) phenotype in vitro and in vivo.ObjectivesThe aim of this study was to assess the efficacy of FIX-FIAV in plasma from HA patients using thrombin generation (TG) and intrinsic clotting activity (activated partial thromboplastin time [APTT]) analyses.MethodsPlasma obtained from 21 patients with HA (>18 years; 7 mild, 7 moderate, and 7 severe patients) was spiked with FIX-FIAV. The FXIa-triggered TG lag time and APTT were quantified in terms of FVIII-equivalent activity using FVIII calibration for each patient plasma.ResultsThe linear, dose-dependent improvement in the TG lag time and APTT reached its maximum with approximately 400% to 600% FIX-FIAV in severe HA plasma and with approximately 200% to 250% FIX-FIAV in nonsevere HA plasma. The cofactor-independent contribution of FIX-FIAV was therefore suggested and confirmed by the addition of inhibitory anti-FVIII antibodies to nonsevere HA plasma, resulting in a FIX-FIAV response similar to severe HA plasma. Addition of 100% (5 μg/mL) FIX-FIAV mitigated the HA phenotype from severe to moderate (from ConclusionFIX-FIAV is capable of increasing the FVIII-equivalent activity and coagulation activity in plasma from HA patients, thereby mitigating the HA phenotype. Hence, FIX-FIAV could serve as a potential treatment for HA patients with or without inhibitors.Thrombosis and Hemostasi