37 research outputs found
Does observed vs expected lung head ratio correlate with neonatal survival in infants with congenital diaphragmatic hernias?
To investigate whether observed vs expected (O/E) lung–to–head ratio (LHR) correlates with neonatal survival in infants with congenital diaphragmatic hernia (CDH). Secondary goal was to correlate O/E LHR with Oxygenation index (OI) in the first 12 hours of life
Maternal intention to breast-feed and breast-feeding outcomes in term and preterm infants: Pregnancy Risk Assessment Monitoring System (PRAMS), 2000–2003
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CSF Neurotransmitter Studies: An Infant With Ascorbic Acid-Responsive Tyrosinemia
• A female newborn infant with Marfanlike habitus experienced lethargy and hypothermia associated with tyrosinemia that was not corrected by the administration of ascorbic acid at 50 mg/day but that subsequently responded to ascorbic acid at 500 mg/day. Cerebrospinal fluid analysis for neurotransmitter metabolites showed elevated concentrations of homovanillic acid and 5-hydroxyindoleacetic acid when the child was symptomatic and normal concentrations after successful ascorbic acid therapy. These observations suggest that a high level of tyrosine in serum can affect the metabolism in the brain of dopamine and serotonin.(Am J Dis Child 134:492-494, 1980
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit
Growth in VLBW infants fed predominantly fortified maternal and donor human milk diets: a retrospective cohort study
<p>Abstract</p> <p>Background</p> <p>To determine the effect of human milk, maternal and donor, on in-hospital growth of very low birthweight (VLBW) infants. We performed a retrospective cohort study comparing in-hospital growth in VLBW infants by proportion of human milk diet, including subgroup analysis by maternal or donor milk type. Primary outcome was change in weight z-score from birth to hospital discharge.</p> <p>Methods</p> <p>Retrospective cohort study.</p> <p>Results</p> <p>171 infants with median gestational age 27 weeks (IQR 25.4, 28.9) and median birthweight 899 g (IQR 724, 1064) were included. 97% of infants received human milk, 51% received > 75% of all enteral intake as human milk. 16% of infants were small-for-gestational age (SGA, < 10<sup>th</sup> percentile) at birth, and 34% of infants were SGA at discharge. Infants fed >75% human milk had a greater negative change in weight z-score from birth to discharge compared to infants receiving < 75% (−0.6 vs, -0.4, p = 0.03). Protein and caloric supplementation beyond standard human milk fortifier was related to human milk intake (p = 0.04). Among infants receiving > 75% human milk, there was no significant difference in change in weight z-score by milk type (donor −0.84, maternal −0.56, mixed −0.45, p = 0.54). Infants receiving >75% donor milk had higher rates of SGA status at discharge than those fed maternal or mixed milk (56% vs. 35% (maternal), 21% (mixed), p = 0.08).</p> <p>Conclusions</p> <p>VLBW infants can grow appropriately when fed predominantly fortified human milk. However, VLBW infants fed >75% human milk are at greater risk of poor growth than those fed less human milk. This risk may be highest in those fed predominantly donor human milk.</p