Saving the fourth generation Higgs with radion mixing

We study Higgs-radion mixing in a warped extra dimensional model with Standard Model fields in the bulk, and we include a fourth generation of chiral fermions. The main problem with the fourth generation is that, in the absence of Higgs-radion mixing, it produces a large enhancement in the Higgs production cross-section, now severely constrained by LHC data. We analyze the production and decay rates of the two physical states emerging from the mixing and confront them with present LHC data. We show that the current signals observed can be compatible with the presence of one, or both, of these Higgs-radion mixed states (the $\phi$ and the $h$), although with a severely restricted parameter space. In particular, the radion interaction scale must be quite low, Lambda_\phi ~ 1-1.3 TeV. If m_\phi ~ 125 GeV, the $h$ state must be heavier (m_h>320 GeV). If m_h ~ 125 GeV, the $\phi$ state must be quite light or close in mass (m_\phi ~ 120 GeV). We also present the modified decay branching ratios of the mixed Higgs-radion states, including flavor violating decays into fourth generation quarks and leptons. The windows of allowed parameter space obtained are very sensitive to the increased precision of upcoming LHC data. During the present year, a clear picture of this scenario will emerge, either confirming or further severely constraining this scenario.Comment: 22 pages, 5 figures, 4 table

CP Asymmetry in Charged Higgs Decays in MSSM

We discuss and compare the charge-parity (CP) asymmetry in the charged Higgs boson decays H -> \bar{u}_i d_j for the second and third generation quarks in the minimal supersymmetric standard model. As part of the analysis, we derive some general analytical formulas for the imaginary parts of two-point and three-point scalar one-loop integrals and use them for calculating vectorial and tensorial type integrals needed for the problem under consideration. We find that, even though each decay mode has a potential to yield a CP asymmetry larger than 10%, further analysis based on the number of required charged Higgs events at colliders favors the \bar{t}b, \bar{c}b, and \bar{c}s channels, whose asymmetry could reach 10-15% in certain parts of the parameter space.Comment: 25 pages, 9 figures. Discussion about charged Higgs observability added, typos corrected, accepted for publication in PR

Higgs Phenomenology in Warped Extra-Dimensions with a 4th Generation

We study a warped extra-dimension scenario where the Standard Model fields lie in the bulk, with the addition of a fourth family of fermions. We concentrate on the flavor structure of the Higgs couplings with fermions in the flavor anarchy ansatz. Even without a fourth family, these couplings will be generically misaligned with respect to the SM fermion mass matrices. The presence of the fourth family typically enhances the misalignment effects and we show that one should expect them to be highly non-symmetrical in the ${(34)}$ inter-generational mixing. The radiative corrections from the new fermions and their flavor violating couplings to the Higgs affect negligibly known experimental precision measurements such as the oblique parameters and $Z\to b {\bar b}$ or $Z \to \mu^+ \mu^-$. On the other hand, $\Delta F=1,2$ processes, mediated by tree-level Higgs exchange, as well as radiative corrections to $b \to s \gamma$ and $\mu \to e\gamma$ put some generic pressure on the allowed size of the flavor violating couplings. But more importantly, these couplings will alter the Higgs decay patterns as well as those of the new fermions, and produce very interesting new signals associated to Higgs phenomenology in high energy colliders. These might become very important indirect signals for these type of models as they would be present even when the KK mass scale is high and no heavy KK particle is discovered.Comment: 39 pages, 6 figure

Rare Decay of the Top t->c l lbar and Single Top Production at International Linear Collider

We perform a complete and detailed analysis of the flavor changing neutral current rare top quark decays t-> cl+l- and t->c nu_i bar nu_i at one-loop level in the Standard Model, Two Higgs Doublet Models (I and II) and in MSSM. The branching ratios are very small in all models, O(10^-14), except for the case of the unconstrained MSSM, where they can reach O(10^-6) for e+e- and nu_i bar nu_i, and O(10^-5) for tau+ tau-. This branching ratio is comparable to the ones for t-> c V, cH. We also study the production rates of single top and the forward-backward asymmetry in e+e- -> t cbar and comment on the observability of such a signal at the International Linear Collider.Comment: 32 pages and 18 figures, minor clarification in the text, references added. To be published in Phys. Rev.

Environmental drivers of variation in bleaching severity of Acropora species during an extreme thermal anomaly

High sea surface temperatures caused global coral bleaching during 2015–2016. During this thermal stress event, we quantified within- and among-species variability in bleaching severity for critical habitat-forming Acropora corals. The objective of this study was to understand the drivers of spatial and species-specific variation in the bleaching susceptibility of these corals, and to evaluate whether bleaching susceptibility under extreme thermal stress was consistent with that observed during less severe bleaching events. We surveyed and mapped Acropora corals at 10 sites (N = 596) around the Lizard Island group on the northern Great Barrier Reef. For each colony, bleaching severity was quantified using a new image analysis technique, and we assessed whether small-scale environmental variables (depth, microhabitat, competition intensity) and species traits (colony morphology, colony size, known symbiont clade association) explained variation in bleaching. Results showed that during severe thermal stress, bleaching of branching corals was linked to microhabitat features, and was more severe at reef edge compared with lagoonal sites. Bleaching severity worsened over a very short time-frame (∼1 week), but did not differ systematically with water depth, competition intensity, or colony size. At our study location, within- and among-species variation in bleaching severity was relatively low compared to the level of variation reported in the literature. More broadly, our results indicate that variability in bleaching susceptibility during extreme thermal stress is not consistent with that observed during previous bleaching events that have ranged in severity among globally dispersed sites, with fewer species escaping bleaching during severe thermal stress. In addition, shaded microhabitats can provide a refuge from bleaching which provides further evidence of the importance of topographic complexity for maintaining the biodiversity and ecosystem functioning of coral reefs

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction

The protein tau and its isoforms are associated with several neurodegenerative diseases, many of which are characterized by greater deposition of the 4-repeat (4R) tau isoform; however, the role of 4R tau in disease pathogenesis remains unclear. We created antisense oligonucleotides (ASOs) that alter the ratio of 3R to 4R tau to investigate the role of specific tau isoforms in disease. Preferential expression of 4R tau in human tau-expressing (hTau-expressing) mice was previously shown to increase seizure severity and phosphorylated tau deposition without neuronal or synaptic loss. In this study, we observed strong colocalization of 4R tau within reactive astrocytes and increased expression of pan-reactive and neurotoxic genes following 3R to 4R tau splicing ASO treatment in hTau mice. Increasing 4R tau levels in primary astrocytes provoked a similar response, including a neurotoxic genetic profile and diminished homeostatic function, which was replicated in human induced pluripotent stem cell-derived (iPSC-derived) astrocytes harboring a mutation that exhibits greater 4R tau. Healthy neurons cultured with 4R tau-expressing human iPSC-derived astrocytes exhibited a higher firing frequency and hypersynchrony, which could be prevented by lowering tau expression. These findings support a potentially novel pathway by which astrocytic 4R tau mediates reactivity and dysfunction and suggest that astrocyte-targeted therapeutics against 4R tau may mitigate neurodegenerative disease progression

Chargino contributions to ϵ′/ϵ\epsilon^{\prime}/ \epsilon in the left-right supersymmetric model

We analyze the chargino contributions to the CP violating ratio $\epsilon^{\prime}/\epsilon$ in the left-right supersymmetric model. We study the possibility that these contributions alone can saturate the experimental value of $\epsilon^{\prime}/\epsilon$. We derive conservative bounds on supersymmetric flavor violation parameters in the up squark LL, RR, LR and RL sectors, using the mass insertion approximation. While the LL bounds are found to be consistent with the MSSM values, the LR constraints are new and much stronger.Comment: 14 pages, 1 figure, 2 table

The Neutron Electric Dipole Moment and CP-violating Couplings in the Supersymmetric Standard Model without R-parity

We analyze the neutron electric dipole moment (EDM) in the Minimal Supersymmetric Model with explicit R-parity violating terms. The leading contribution to the EDM occurs at the 2-loop level and is dominated by the chromoelectric dipole moments of quarks, assuming there is no tree-level mixings between sleptons and Higgs bosons or between leptons and gauginos. Based on the experimental constraint on the neutron EDM, we set limits on the imaginary parts of complex couplings ${\lambda'}_{ijk}$ and ${\lambda}_{ijk}$ due to the virtual b-loop or tau-loop.Comment: final manuscript to appear in Phys. Rev. D, 15 pages, latex, 4 figures include

Circular economy inspired imaginaries for sustainable innovations

In this chapter, Narayan and Tidström draw on the concept of imaginaries to show how Circular Economy (CE) can facilitate values that enable sustainable innovation. Innovation is key for sustainability, however, understanding and implementing sustainable innovation is challenging, and identifying the kind of actions that could direct sustainable innovations is important. The findings of this study indicate that CE-inspired imaginaries enable collaboration and by relating such imaginaries to common and shared social and cultural values, intermediaries could motivate actors into taking actions that contribute to sustainable innovation.fi=vertaisarvioitu|en=peerReviewed

Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference

The American Initiative in Mast Cell Diseases (AIM) held its inaugural investigator conference at Stanford University School of Medicine in May 2019. The overarching goal of this meeting was to establish a Pan-American organization of physicians and scientists with multidisciplinary expertise in mast cell disease. To serve this unmet need, AIM envisions a network where basic, translational, and clinical researchers could establish collaborations with both academia and biopharma to support the development of new diagnostic methods, enhanced understanding of the biology of mast cells in human health and disease, and the testing of novel therapies. In these AIM proceedings, we highlight selected topics relevant to mast cell biology and provide updates regarding the recently described hereditary alpha-tryptasemia. In addition, we discuss the evaluation and treatment of mast cell activation (syndromes), allergy and anaphylaxis in mast cell disorders, and the clinical and biologic heterogeneity of the more indolent forms of mastocytosis. Because mast cell disorders are relatively rare, AIM hopes to achieve a coordination of scientific efforts not only in the Americas but also in Europe by collaborating with the well-established European Competence Network on Mastocytosis.The research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) (award no. R13TR002722 to J.G.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We thank The Mast Cell Disease Society, Inc (TMS), a national 501c3 nonprofit, for their partnership and support of AIM, for patient-centered research, and for sponsoring international physicians at this inaugural meeting. J.G. expresses gratitude for the support of the Charles and Ann Johnson Foundation, the staff of the Stanford Mastocytosis Center, and the Stanford Cancer Institute Innovation Fund. M.C., J.J.L., and D.D.M. are supported in part by the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, NIH. D.F.D. is supported by the Asthma and Allergic Diseases Cooperative Research Centers Opportunity Fund (award no. U19AI07053 from the NIH). P.V. has been supported by the Austrian Science Fund (FWF) (grant nos. F4701-B20, F4704-B20, and P32470-B)