Enzimas: qué son y para qué sirven

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Doble hélice, genes y cromosomas

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¿Por qué proliferan las células?

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Metabolismo de amitrol (3-amino-1,2,4-triazol) en mamíferos : sobre su influencia en la biosíntesis de proteinas

Tesis-Universidad Complutense de Madrid, 1.971.Fac. de Ciencias QuímicasTRUEProQuestpu

Site-specificity of pea histone acetyltransferase B in vitro

Histone acetyltransferase B from pea embryonic axes has been purified approximately 300-fold by a combination of chromatographic procedures, including affinity chromatography on histone-agarose. The enzyme preparation has been used for the in vitro transfer of acetyl groups from [1-14C]acetyl-CoA to non-acetylated pea histone H4. Up to three acetyl groups can be introduced into the histone. The resulting mono-, di-, and triacetylated H4 isoforms were separated and sequenced to determine the acetylated sites. Only sites 5, 12, and 16 were used by histone acetyltransferase B, but no clear preference among them was observed. The absence of modification of other potentially acetylatable sites is another indication that acetylation of the different lysine residues in the N-terminal H4 tail serves as a specific signal in different nuclear processes

Dental arch changes from adolescence to adulthood in a spanish population : a cross-sectional study

Objectives: Given the controversy in the literature about the variations in intercanine and intermolar distances and arch perimeter once the eruption of permanent teeth is completed, the aims of this study were to assess the changes of these measures with age, analyzing its sexual dimorphism and variability in a Spanish population. Study Design: 188 Spanish individuals distributed in three age groups were selected: 63 adolescents (mean age: 14.15 years), 62 young adults (mean age: 21.9 years) and 63 adults (mean age: 40 years). The intercanine and intermolar distances and arch perimeter were measured in each dental cast from each individual of the sample using a digital method. The results were compared between sex and age groups, the sexual dimorphism percentage (%) of each measure and its variability coefficient (VC%) were calculated. Results: The results depend on sex and age and, therefore, these two factors will be analyzed jointly for each of them with the variation coefficient of the measurement. Intercanine and intermolar distances and arch perimeter were greater in men than in women, especially in the young adult and adult groups. Conclusions: The intercanine distance and arch perimeter tended to decrease with age particularly in the female sex, whilst the intermolar distance didn't undergo significant changes. The intercanine distance is the dimension that presented the greatest variability, whereas the intermolar distance presented the least. The changes occur in the transition from adolescence (14 years of age) to adulthood (22 years of age) and the subsequent alterations are not relevant. © Medicina Oral S. L

Tooth size changes with age in a Spanish population : percentile tables

Objectives: The aims of this work were: firstly, to draw up tables of percentile tooth sizes similar to those of Sanin and Savara for three age groups of a Spanish population; secondly, to describe changes in tooth size between those groups over time, as well as observing any sexual dimorphism and, finally, to compare both the Spanish and Sanin and Savara's American population samples. Material and methods: The sample included 359 patients and was divided into three age groups: adolescents, young adults and adults, of both genders. After dental cast digitalization, mesiodistal tooth-size was measured on each dental cast using a digital method. Dental size tables organized by percentiles for each group of age and gender were drawn up. Percentiles under 30 were considered as small, between 30 and 70 as average, and above 70 as large. As symmetry was found between contralateral teeth, the mean between the teeth of the two semi-arches was considered. Results: The mesiodistal tooth sizes of adolescents did not present statistically significant differences between genders, in contrast to the two other age groups. Conclusions: Mesiodistal tooth diameters tended to diminish with age, especially in women, in the Spanish population. The values obtained for our dental tables, organized by percentiles, were slightly higher than those found by Sanin and Savara in an American population, especially for women. © Medicina Oral S. L

Clinical behavior of children with infantile cerebral palsy after ozone therapy

Objective. The aim of this study was to determine the usefulness of ozone therapy in the treatment of Infantile Cerebral Palsy (ICP). Patients and methods. A non-controlled clinical assay was made in the Ozone Research Center (CIO), Havana, Cuba from January 2013 to January 2014. The sample was constituted by patients remitted to pediatrics consultation of CIO, to whom inclusion and exclusion criteria were applied. The study group involved 45 patients, from 1 month of birth to 8 years, with cerebral palsy of hypoxic-ischemic cause. The evaluation criteria were: evolution of the motor disorder according to the Gross Motor Function Classification System (GMFCS) scale, modification of muscle tone (Ashworth modified scale) and response to treatment (O?Brien modified scale). The way of administration was rectal insufflation; concentrations between 15, 20, 25 and 30 mg/L were used, volumes varied according to age, making calculation of the dose of ozone according to kilograms of weight. Cycles of 20 sessions, every 3 months were indicated, until completing 4 in 16 months. Patients were clinically evaluated, according to the scales used, before and after each cycle. Results and Discussion. The best answer to treatment was obtained in the group aged ? 4 years. The variables analyzed showed a significant improvement when the ozone treatment concluded. With respect to the evolution of the motor disorder, in 65 % of cases it improved. In the group of children below 4 years, the response was better in relation to the muscle tone. Response to treatment, according to the relatives? criteria, was of 70 % of the children with marked improvement in the tone and muscle function. Conclusions. The greatest percentage of patients improved in the evolution of the motor disorder; when the Manual Ability Classification System (MACS) scale was applied, more than half the patients showed an improvement. A high percentage of children get a satisfactory result regarding muscle tone and motor function. No side effects were present in any of the cases during the study

Índice de progreso social del distrito de Sullana

La presente investigación tiene como objetivo analizar el índice de progreso social en la Provincia de Sullana en Piura, evaluar la relación existente entre el crecimiento de la ciudad en términos económicos y su desarrollo en términos de progreso social en el año 2018, establecer la infraestructura e instrumentos que permitan a sus ciudadanos mejorar su calidad de vida con inclusión y generar oportunidades. La metodología utilizada considera el tipo de naturaleza no experimental del tipo longitudinal, para Hernández, Fernández y Baptista (2003) los diseños longitudinales son aquellos que recolectan a través del tiempo en periodos, para hacer inferencia respecto al cambio, sus determinantes y consecuencias. El tamaño de la muestra a la que se aplicó el Índice de Progreso Social es la encuesta de 301 hogares, de las cuales 168 hogares ubicada en la Zona 1 considerando el distrito de Sullana y 133 hogares ubicadas en la Zona 2 considerando los distritos de Bellavista, Ignacio Escudero, Lancones, Marcavelica, Miguel Checa, Querecotillo y Salitral, en la provincia de Sullana, esta zonificación fue basada principalmente en la densidad poblacional y actividades comerciales en común. Los resultados de la investigación realizada en la provincia de Sullana, en el sector externo no están aprovechando las oportunidades y por la falta de atención del gobierno central no se le permite neutralizar las amenazas. En el sector interno, la provincia logra describir una organización internamente débil, no logra aprovechar los beneficios presentes en su territorio, gestión gubernamental deficiente y no refleja bienestar de la población. Estos factores al ser controlables tiene la opción de afianzarlos con inversión en tecnología, infraestructura, salud y educación, innovación e investigación, con visión clara y de largo plazo que se desarrolle a través de la municipalidad y el auge de la provinciaThe objective of this research is to analyze the index of social progress in the Province of Sullana in Piura, to evaluate the relationship between the growth of the city in economic terms and its development in terms of social progress in 2018, to establish the infrastructure and instruments that allow its citizens to improve their life quality with inclusion and to generate opportunities. The methodology applied considers the sort non-experimental nature of the longitudinal type, for Hernández, Fernández and Baptista (2003) the longitudinal designs are those that collect in periods over time, making inference about the change, its determinants and consequences. The size of the sample which the social progress index is applied in the survey of 301 households, of wich 168 households are Zone 1 considering the district of Sullana and 133 households are Zone 2 considering the districts of Bellavista, Ignacio Escudero, Lancones, Marcavelica, Miguel Checa, Querecotillo and Salitral from Sullana province, this zones was based mainly on population density and commercial activities in common. The results of the research held on Sullana province, the external sector, does not take advantage of the opportunities and the lack of attention due to central government does not allow it neutralizing the threats. In the domestic sector, the province manages to describe an internally weak organization, fails to take advantage of the benefits present in its territory, poor government management that does not reflect the well-being on the population. These factors, being controllable, have the option of consolidate them with investment in technology, infrastructure, healthcare and education, innovation and research, with a clear and long-term vision being developed through the municipality and the boom of the provinceTesi

Detection and characterization of Plasmodium spp. by semi-nested multiplex PCR both in mosquito vectors and in humans residing in historically endemic areas of Paraguay

Corresponding author at: Department of Tropical Medicine, Research Institute in Health Science (IICS-UNA), National University of Asunción, Campus UNA, San Lorenzo, Paraguay. E-mail addresses: [email protected], [email protected]. (F. del Puerto).In Paraguay, no cases of Malaria have been recorded since 2011. Microscopy and the SnM-PCR technique were implemented to detect and characterize Plasmodium spp. both in mosquitoes and in humans residing in historically endemic areas of Paraguay, to evaluate the possibility of finding asymptomatic cases and/or Plasmodium parasites circulating in anophelines. Between 2013 and 2015, 361 human blood samples were collected on filter paper, and between 2016 and 2017, 938 female Anopheles mosquitoes were captured in 15 Paraguayan localities. All the diagnostic techniques showed negative results. We observed no asymptomatic case or Plasmodium circulating in vectors.Consejo Nacional de Ciencia y TecnologíaPrograma Paraguayo para el Desarrollo de la Ciencia y Tecnología. Proyectos de investigación y desarroll