Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD

Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages. Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score. Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution and no association between longitudinal changes in ACD and in cognitive scores. Conclusions: ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized. Trial registration: The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42

Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease

Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD)

A Review and Classification of Approaches for Dealing with Uncertainty in Multi-Criteria Decision Analysis for Healthcare Decisions

The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Multi-criteria decision analysis (MCDA) is increasingly used to support decisions in healthcare involving multiple and conflicting criteria. Although uncertainty is usually carefully addressed in health eco-nomic evaluations, whether and how the different sources of uncertainty are dealt with and with what methods in MCDA is less known. The objective of this study is to review how uncertainty can be explicitly taken into account in MCDA and to discuss which approach may be appro-priate for healthcare decision makers. A literature review was conducted in the Scopus and PubMed databases. Two reviewers independently categorized studies according to research areas, the type of MCDA used, and the approach used to quantify uncertainty. Selected full text articles wer

Modeling of heterotrophic bacteria in a water distribution system

Heterotrophic plate count (HPC) is an indicator widely used for routine microbiological monitoring of water quality in distribution systems.This paper identifies the factors explaining the spatiotemporal distribution of HPC. It presents predictive models for predicting HPC in water distribution systems as a possible substitute for high-frequency on-site monitoring of HPC concentrations.La num\ue9ration des bact\ue9ries h\ue9t\ue9rotrophes (NBH) est un indicateur largement utilis\ue9 aux fins de la surveillance microbiologique ordinaire de la qualit\ue9 de l'eau dans les r\ue9seaux de distribution. Ce document identifie les facteurs qui expliquent la distribution spatiotemporelle des NBH. On y pr\ue9sente des mod\ue8les permettant de pr\ue9dire les NBH dans les r\ue9seaux de distribution comme substitut potentiel de la surveillance in situ \ue0 haute fr\ue9quence des concentrations des bact\ue9ries h\ue9t\ue9rotrophes.Peer reviewed: YesNRC publication: Ye

Rapport présenté à S. Exc. le Ministre de l'instruction publique et des cultes par M. P. Mérimée, sénateur, au nom de la commission chargée d'examiner les modifications à introduire dans l'organisation de la Bibliothèque impériale.

Mérimée Prosper, Allard Nelzir, Lélut Louis-Francisque, Marchand A., Chaix d'Est-Ange Gustave, Lascoux , Pelletier J., Laborde Léon de, de Longperrier A., Saulcy Louis Félicien de, Rouland Gustave. Rapport présenté à S. Exc. le Ministre de l'instruction publique et des cultes par M. P. Mérimée, sénateur, au nom de la commission chargée d'examiner les modifications à introduire dans l'organisation de la Bibliothèque impériale.. In: Bulletin administratif de l'instruction publique. Tome 9 n°103, juillet 1858. pp. 143-170

Rapport présenté à S. Exc. le Ministre de l'instruction publique et des cultes par M. P. Mérimée, sénateur, au nom de la commission chargée d'examiner les modifications à introduire dans l'organisation de la Bibliothèque impériale.

Mérimée Prosper, Allard Nelzir, Lélut Louis-Francisque, Marchand A., Chaix d'Est-Ange Gustave, Lascoux , Pelletier J., Laborde Léon de, de Longperrier A., Saulcy Louis Félicien de, Rouland Gustave. Rapport présenté à S. Exc. le Ministre de l'instruction publique et des cultes par M. P. Mérimée, sénateur, au nom de la commission chargée d'examiner les modifications à introduire dans l'organisation de la Bibliothèque impériale.. In: Bulletin administratif de l'instruction publique. Tome 9 n°103, juillet 1858. pp. 143-170