Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD)

Audrain, C

Auffret, A

Bakardjian, H

Baldacci, F

Batrancourt, B

Benakki, I

Benali, H

Bertin, H

Bertin, Hugo

Bertrand, A

Boukadida, L

Boukadida, Laurie

Cacciamani, F

Cacciamani, Federica

Causse, V

Cavedo, E

Cherif Touil, S

Chiesa, P A

Colliot, O

Dalla Barba, G

Depaulis, M

Dos Santos, A

Dubois, B

Dubois, Bruno

Dubois, M

Epelbaum, S

Epelbaum, St\ue9phane

Fontaine, B

Francisque, H

Gagliardi, G

Gagliardi, Geoffroy

Genin, A

Genthon, R

Glasman, P

Gombert, F

Habert, M O

Habert, Marie-Odile

Hampel, H

Hampel, Harald

Hewa, H

Houot, M

Jungalee, N

Kas, A

Kilani, M

La Corte, V

Le Roy, F

Lehericy, S

Letondor, C

Levy, M

Lista, S

Lowrey, M

Ly, J

Makiese, O

Masetti, I

Mendes, A

Metzinger, C

Michon, A

Mochel, F

Nait Arab, R

Nyasse, F

Perrin, C

Poirier, F

Poisson, C

Potier, M C

R\ue9villon, Marie

Ratovohery, S

Revillon, M

Rojkova, K

Santos-Andrade, K

Schindler, R

Servera, M C

Seux, L

Simon, V

Skovronsky, D

Tandetnik, Caroline

Thiebaut, M

Uspenskaya, O

Vlaincu, M

English

Background: Subjective cognitive decline (SCD) may result from m any conditions, including Alzheimer's disease (AD). Objective: In this study, we searched for a specific pattern of SCD in asymptomatic individuals at risk for AD. Methods: Cognitively normal older adults (N=318) reporting SCD and their informants were enrolled in the INSIGHT-PreAD cohort. We examined the relationship between six SCD measures and both cognitive scores and AD neuroimaging markers (amyloid burden, hippocampal atrophy and brain hypometabolism). An awareness of cognitive decline index (ACDI) has been introduced based on the subject-informant discrepancy in a questionnaire of SCD and participants with low versus high awareness were compared. Results: Scores in the INSIGHT-PreAD SCD questionnaires did not correlate with AD neuroimaging markers. As well, no correlation has been found between SCD measures and cognitive scores. Comparing subjects with a low (n=19) and high (n=86) level of awareness, no significant difference in terms of demography, neuropsychiatric symptoms, autonomy, quality of life, cognition, and hippocampal volume was found. However, the "low awareness" group showed greater amyloid burden and lower cortical metabolism, compared to the "high awareness" group. Conclusion: This study provided additional evidence that reporting SCD by itself is not a specific symptom of preclinical AD. Conversely, a low cognitive awareness (namely, when subjects report fewer difficulties than their relatives do) may represent a very early form of anosognosia and serve as a specific indicator of preclinical AD. This finding is of key importance as an enrichment factor to consider in both clinical practice and research trials

Révillon, Marie

Epelbaum, Stéphane

Dubois

Bruno (INSIGHT pre-AD study group: Audrain C

Auffret A

Bakardjian H

Baldacci F

Batrancourt B

Benakki I

Benali H

Bertin H

Bertrand A

Boukadida L

Cacciamani F

Causse V

Cavedo E

Cherif Touil S

Chiesa PA

Colliot O

Dalla Barba G

Depaulis M

Dos Santos A

Dubois B

Dubois M

Epelbaum S

Fontaine B

Francisque H

Gagliardi G

Genin A

Genthon R

Glasman P

Gombert F

Habert MO

Hampel H

Hewa H

Houot M

Jungalee N

Kas A

Kilani M

La Corte V

Le Roy F

Lehericy S

Letondor C

Levy M

Lista S

Lowrey M

Ly J

Makiese O

Masetti I

Mendes A

Metzinger C

Michon A

Mochel F

Nait Arab R

Nyasse F

Perrin C

Poirier F

Poisson C

Potier MC

Ratovohery S

Revillon M

Rojkova K

Santos-Andrade K

Schindler R

Servera MC

Seux L

Simon V

Skovronsky D

Thiebaut M

Uspenskaya O

Vlaincu M.

Archivio della Ricerca - Università di Pisa

Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease

Archivio istituzionale della ricerca - Università di Trieste

https://arts.units.it/retrieve/handle/11368/2941512/419590/2941512_10.3233%40JAD-170399-PostPrint.pdf

Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease

Abstract

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Archivio della Ricerca - Università di Pisa

Archivio istituzionale della ricerca - Università di Trieste