1,394 research outputs found
Spanning forest polynomials and the transcendental weight of Feynman graphs
We give combinatorial criteria for predicting the transcendental weight of
Feynman integrals of certain graphs in theory. By studying spanning
forest polynomials, we obtain operations on graphs which are weight-preserving,
and a list of subgraphs which induce a drop in the transcendental weight.Comment: 30 page
Energy landscape of relaxed amorphous silicon
We analyze the structure of the energy landscape of a well-relaxed 1000-atom
model of amorphous silicon using the activation-relaxation technique (ART
nouveau). Generating more than 40,000 events starting from a single minimum, we
find that activated mechanisms are local in nature, that they are distributed
uniformly throughout the model and that the activation energy is limited by the
cost of breaking one bond, independently of the complexity of the mechanism.
The overall shape of the activation-energy-barrier distribution is also
insensitive to the exact details of the configuration, indicating that
well-relaxed configurations see essentially the same environment. These results
underscore the localized nature of relaxation in this material.Comment: 8 pages, 12 figure
Knudsen gas in a finite random tube: transport diffusion and first passage properties
We consider transport diffusion in a stochastic billiard in a random tube
which is elongated in the direction of the first coordinate (the tube axis).
Inside the random tube, which is stationary and ergodic, non-interacting
particles move straight with constant speed. Upon hitting the tube walls, they
are reflected randomly, according to the cosine law: the density of the
outgoing direction is proportional to the cosine of the angle between this
direction and the normal vector. Steady state transport is studied by
introducing an open tube segment as follows: We cut out a large finite segment
of the tube with segment boundaries perpendicular to the tube axis. Particles
which leave this piece through the segment boundaries disappear from the
system. Through stationary injection of particles at one boundary of the
segment a steady state with non-vanishing stationary particle current is
maintained. We prove (i) that in the thermodynamic limit of an infinite open
piece the coarse-grained density profile inside the segment is linear, and (ii)
that the transport diffusion coefficient obtained from the ratio of stationary
current and effective boundary density gradient equals the diffusion
coefficient of a tagged particle in an infinite tube. Thus we prove Fick's law
and equality of transport diffusion and self-diffusion coefficients for quite
generic rough (random) tubes. We also study some properties of the crossing
time and compute the Milne extrapolation length in dependence on the shape of
the random tube.Comment: 51 pages, 3 figure
Constraints on early dark energy from CMB lensing and weak lensing tomography
Dark energy can be studied by its influence on the expansion of the Universe
as well as on the growth history of the large-scale structure. In this paper,
we follow the growth of the cosmic density field in early dark energy
cosmologies by combining observations of the primary CMB temperature and
polarisation power spectra at high redshift, of the CMB lensing deflection
field at intermediate redshift and of weak cosmic shear at low redshifts for
constraining the allowed amount of early dark energy. We present these
forecasts using the Fisher-matrix formalism and consider the combination of
Planck-data with the weak lensing survey of Euclid. We find that combining
these data sets gives powerful constraints on early dark energy and is able to
break degeneracies in the parameter set inherent to the various observational
channels. The derived statistical 1-sigma-bound on the early dark energy
density parameter is sigma(Omega_d^e)=0.0022 which suggests that early dark
energy models can be well examined in our approach. In addition, we derive the
dark energy figure of merit for the considered dark energy parameterisation and
comment on the applicability of the growth index to early dark energy
cosmologies.Comment: 25 pages, 14 figures, 3 tables; v2: very minor additions, updated to
match version to be published in JCA
Early Dark Energy at High Redshifts: Status and Perspectives
Early dark energy models, for which the contribution to the dark energy
density at high redshifts is not negligible, influence the growth of cosmic
structures and could leave observable signatures that are different from the
standard cosmological constant cold dark matter (CDM) model. In this
paper, we present updated constraints on early dark energy using geometrical
and dynamical probes. From WMAP five-year data, baryon acoustic oscillations
and type Ia supernovae luminosity distances, we obtain an upper limit of the
dark energy density at the last scattering surface (lss), (95% C.L.). When we include higher redshift
observational probes, such as measurements of the linear growth factors,
Gamma-Ray Bursts (GRBs) and Lyman- forest (\lya), this limit improves
significantly and becomes (95%
C.L.). Furthermore, we find that future measurements, based on the
Alcock-Paczy\'nski test using the 21cm neutral hydrogen line, on GRBs and on
the \lya forest, could constrain the behavior of the dark energy component and
distinguish at a high confidence level between early dark energy models and
pure CDM. In this case, the constraints on the amount of early dark
energy at the last scattering surface improve by a factor ten, when compared to
present constraints. We also discuss the impact on the parameter , the
growth rate index, which describes the growth of structures in standard and in
modified gravity models.Comment: 11 pages, 9 figures and 4 table
Residual stress measurement round robin on an electron beam welded joint between austenitic stainless steel 316L(N) and ferritic steel P91
This paper is a research output of DMW-Creep project which is part of a national UK programme through the RCUK Energy programme and India's Department of Atomic Energy. The research is focussed on understanding the characteristics of welded joints between austenitic stainless steel and ferritic steel that are widely used in many nuclear power generating plants and petrochemical industries as well as conventional coal and gas-fired power systems. The members of the DMW-Creep project have under- taken parallel round robin activities measuring the residual stresses generated by a dissimilar metal weld (DMW) between AISI 316L(N) austenitic stainless steel and P91 ferritic-martensitic steel. Electron beam (EB) welding was employed to produce a single bead weld on a plate specimen and an additional smoothing pass (known cosmetic pass) was then introduced using a defocused beam. The welding re- sidual stresses have been measured by five experimental methods including (I) neutron diffraction (ND), (II) X-Ray diffraction (XRD), (III) contour method (CM), (IV) incremental deep hole drilling (iDHD) and (V) incremental centre hole drilling (iCHD). The round robin measurements of weld residual stresses are compared in order to characterise surface and sub-surface residual stresses comprehensively
Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE)—an open-labelled pilot randomized controlled trial
Background
Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice is currently limited to in vitro, animal and observational human case-series data, with no previous randomized controlled trials (RCTs).
Objectives
This pilot RCT aimed to determine the feasibility of conducting a clinical trial to examine if adjunctive clindamycin with standard therapy has greater efficacy than standard therapy alone for S. aureus infections.
Methods
We performed an investigator-initiated, open-label, multicentre, pilot RCT (ACTRN12617001416381p) in adults and children with severe S. aureus infections, randomized to standard antibiotic therapy with or without clindamycin for 7 days.
Results
Over 28 months, across nine sites, 127 individuals were screened and 34 randomized, including 11 children (32%). The primary outcome—number of days alive and free of systemic inflammatory response syndrome ≤14 days—was similar between groups: clindamycin (3 days [IQR 1–6]) versus standard therapy (4 days [IQR 0–8]). The 90 day mortality was 0% (0/17) in the clindamycin group versus 24% (4/17) in the standard therapy group. Secondary outcomes—microbiological relapse, treatment failure or diarrhoea—were similar between groups.
Conclusions
As the first clinical trial assessing adjunctive clindamycin for S. aureus infections, this study indicates feasibility and that adults and children can be incorporated into one trial using harmonized endpoints, and there were no safety concerns. The CASSETTE trial will inform the definitive S. aureus Network Adaptive Platform (SNAP) trial, which includes an adjunctive clindamycin domain and participants with non-severe disease
The price of rapid exit in venture capital-backed IPOs
This paper proposes an explanation for two empirical puzzles surrounding initial public offerings (IPOs). Firstly, it is well documented that IPO underpricing increases during “hot issue” periods. Secondly, venture capital (VC) backed IPOs are less underpriced than non-venture capital backed IPOs during normal periods of activity, but the reverse is true during hot issue periods: VC backed IPOs are more underpriced than non-VC backed ones. This paper shows that when IPOs are driven by the initial investor’s desire to exit from an existing investment in order to finance a new venture, both the value of the new venture and the value of the existing firm to be sold in the IPO drive the investor’s choice of price and fraction of shares sold in the IPO. When this is the case, the availability of attractive new ventures increases equilibrium underpricing, which is what we observe during hot issue periods. Moreover, I show that underpricing is affected by the severity of the moral hazard problem between an investor and the firm’s manager. In the presence of a moral hazard problem the degree of equilibrium underpricing is more sensitive to changes in the value of the new venture. This can explain why venture capitalists, who often finance firms with more severe moral hazard problems, underprice IPOs less in normal periods, but underprice more strongly during hot issue periods. Further empirical implications relating the fraction of shares sold and the degree of underpricing are presented
Light propagation in statistically homogeneous and isotropic universes with general matter content
We derive the relationship of the redshift and the angular diameter distance
to the average expansion rate for universes which are statistically homogeneous
and isotropic and where the distribution evolves slowly, but which have
otherwise arbitrary geometry and matter content. The relevant average expansion
rate is selected by the observable redshift and the assumed symmetry properties
of the spacetime. We show why light deflection and shear remain small. We write
down the evolution equations for the average expansion rate and discuss the
validity of the dust approximation.Comment: 42 pages, no figures. v2: Corrected one detail about the angular
diameter distance and two typos. No change in result
Lighthouse Schools and Crop Museums in the Philippines
In The Philippines, Lighthouse Schools (LSs) and school-based Crop Museums (CMs) serve as repositories of crop biodiversity. Specifically, LSs are research sites where the integration of school feeding, nutrition education and school gardens, is demonstrated and evidence is established; while CMs are located within the large network of LS and act as seed banks that enable the multiplication and exchange of crop types and varieties across schools. Together they have helped conserve and promote multiple varieties of traditional and indigenous vegetables (IVs)and fruits
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