The Montello hill: The “Classical Karst” of the Conglomerate Rocks

 Grič Montello je najbrž najbolj tipična morfološka enota krasa, razvitega v konglomeratnih kamninah. Lahko ga štejemo za klasični kras v konglomeratu, primerljivim s klasičnim krasom na apnencu, Tržaškim Krasom. Montello je v tlorisu ovalen, dolg približno 13 km v ZJZ – VSV smeri ter širok okoli 5 km. Razvit je v »montelskem konglomeratu« poznomiocenske starosti (mesinij), ki ga gradijo največ karbonatni prodniki zlepljeni s kalcitnim vezivom, debeline do 2000 m. Montello je oblikovan v cel sistem oblik, nastalih zaradi rečnega uravnavanja in vrezovanja, vidnih na osrednji planoti in sedmih živoskalnih uravnanih teras. Terase so vrezane v pobočje opuščene anticedentne doline. Na rečni uravnavi so se razvile vrtače, večinoma iz grezov pa tudi zaradi točkovnega prenikanja. Vsega skupaj jih je preko 2000. Vrtače na sedmih živoskalnih terasah kažejo različen razvoj in različno velikost glede na starost površja. Kaže, da je bil v začetni fazi morfogeneze vrtač vpliv strukture, to je lezik in razpok, šibak; nasprotno pa je bila poroznost odločujoči dejavnik za razvoj kraškega odtoka.   The Montello hill is, probably, the most typical morphounit between the karsts developed in conglomerate rocks. It may be considered the classical karst of the conglomerates comparable with the Classical Karst of limestones: the Carso of Trieste. The Montello hill consists in an elliptical plan figure, elongated for about13 km in a WSW-ENE direction and a width of about 5 km. The rock unit involved is the “Conglomerato del Montello” of late Miocene age (Messinian), mostly composed by carbonate pebbles bound by a calcitic cement, which is 2000 m thick. The Montello is shaped by a complex system of fluvial planation and incision forms in which are distinguishable a main plateau and a stairs of seven planation rock cut terraces. The terraces are cut in the slope of a dead antecedent valley. On the fluvial planation forms, dolines, mostly of the draw down type but also of the point recharge type, have evolved. In total more than 2000 dolines are present. In the seven rock cut terraces the dolines show different development and dimensions according with the ages of the surfaces. In the first morphogenesis of these dolines and of the caves the control of the plan structures as the bedding surfaces and the fractures seems to have been feeble; on the contrary the porosity of the conglomerate has been a determinant factors for the developmente of the karst drainage.

Supermassive Black Holes and Their Host Galaxies - II. The correlation with near-infrared luminosity revisited

We present an investigation of the scaling relations between Supermassive Black Hole (SMBH) masses (Mbh), and their host galaxies' K-band bulge (Lbul) and total (Ltot) luminosities. The wide-field WIRCam imager at the Canada-France-Hawaii-Telescope (CFHT) was used to obtain the deepest and highest resolution near infrared images available for a sample of 35 galaxies with securely measured Mbh, selected irrespective of Hubble type. For each galaxy, we derive bulge and total magnitudes using a two-dimensional image decomposition code that allows us to account, if necessary, for large- and small-scale disks, cores, bars, nuclei, rings, envelopes and spiral arms. We find that the present-day Mbh-Lbul and Mbh-Ltot relations have consistent intrinsic scatter, suggesting that Mbh correlates equally well with bulge and total luminosity of the host. Our analysis provides only mild evidence of a decreased scatter if the fit is restricted to elliptical galaxies. The log-slopes of the Mbh-Lbul and Mbh-Ltot relations are 0.75+/-0.10 and 0.92+/-0.14, respectively. However, while the slope of the Mbh-Lbul relation depends on the detail of the image decomposition, the characterization of Mbh-Ltot does not. Given the difficulties and ambiguities of decomposing galaxy images into separate components, our results indicate that Ltot is more suitable as a tracer of SMBH mass than Lbul, and that the Mbh-Ltot relation should be used when studying the co-evolution of SMBHs and galaxies.Comment: 19 pages, 3 figures, 7 table

New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation

open5noThe hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments have improved the outcome of patients with both compensated and decompensated liver disease in some specific clinical settings as acute-on-chronic liver failure mortality is still high. Moreover, the incidence of HBV-related hepatocellular carcinoma (HCC) seems to be increasing and represents a major challenge for the transplant team. In the post-transplant setting, combination of anti-HBV immunoglobulins and oral nucleos(t)ides provided significant improvement on graft and patient survival. Furthermore, recent data suggested the possibility of personalized therapeutic algorithms based on pre and post-transplant viral and host risk factors. Finally, liver grafts from HBV core antibody (anti-HBc) positive or hepatitis B surface antigen (HBsAg) donors can be safely used in order to expand the donor pool, considering adequate allocation and tailored prophylaxis after LT. In this review we have focused on the evolution of antiviral therapy for HBV, highlighting useful information to aid the transplant hepatologist in clinical practice.ReviewopenZanetto, Alberto; Ferrarese, Alberto; Bortoluzzi, Ilaria; Burra, Patrizia; Russo, Francesco PaoloZanetto, Alberto; Ferrarese, Alberto; Bortoluzzi, Ilaria; Burra, Patrizia; Russo, FRANCESCO PAOL

Geocoding health data with Geographic Information Systems: a pilot study in northeast Italy for developing a standardized data-acquiring format

Introduction. Geographic Information Systems (GIS) have become an innovative and somewhat crucial tool for analyzing relationships between public health data and environment. This study, though focusing on a Local Health Unit of northeastern Italy, could be taken as a benchmark for developing a standardized national data-acquiring format, providing a step-by-step instructions on the manipulation of address elements specific for Italian language and traditions. Methods. Geocoding analysis was carried out on a health database comprising 268,517 records of the Local Health Unit of Rovigo in the Veneto region, covering a period of 10 years, starting from 2001 up to 2010. The Map Service provided by the Environmental Research System Institute (ESRI, Redlands, CA), and ArcMap 10.0 by ESRI\uae were, respectively, the reference data and the GIS software, employed in the geocoding process. Results. The first attempt of geocoding produced a poor quality result, having about 40% of the addresses matched. A procedure of manual standardization was performed in order to enhance the quality of the results, consequently a set of guiding principle were expounded which should be pursued for geocoding health data. High-level geocoding detail will provide a more precise geographic representation of health related events. Conclusions. The main achievement of this study was to outline some of the difficulties encountered during the geocoding of health data and to put forward a set of guidelines, which could be useful to facilitate the process and enhance the quality of the results. Public health informatics represents an emerging specialty that highlights on the application of information science and technology to public health practice and research. Therefore, this study could draw the attention of the National Health Service to the underestimated problem of geocoding accuracy in health related data for environmental risk assessment

Markers of acute rejection and graft acceptance in liver transplantation.

The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct post-transplant management and a major step towards the personalisation of the immunosuppressive therapy. However, current immunological monitoring after liver transplantation relies mainly on clinical judgment and on immunosuppressive drug levels, without a proper assessment of the real suppression of the immunological system. Various markers have been studied in an attempt to identify a specific indicator of graft rejection and graft acceptance after liver transplantation. Considering acute rejection, the most studied markers are pro-inflammatory and immunoregulatory cytokines and other proteins related to inflammation. However there is considerable overlap with other conditions, and only few of them have been validated. Standard liver tests cannot be used as markers of graft rejection due to their low sensitivity and specificity and the weak correlation with the severity of histopathological findings. Several studies have been performed to identify biomarkers of tolerance in liver transplanted patients. Most of them are based on the analysis of peripheral blood samples and on the use of transcriptional profiling techniques. Amongst these, NK cell-related molecules seem to be the most valid marker of graft acceptance, whereas the role CD4+CD25+Foxp3+ T cells has still to be properly defined

Future of oil and gas development in the western Amazon

The western Amazon is one of the world's last high-biodiversity wilderness areas, characterized by extraordinary species richness and large tracts of roadless humid tropical forest. It is also home to an active hydrocarbon (oil and gas) sector, characterized by operations in extremely remote areas that require new access routes. Here, we present the first integrated analysis of the hydrocarbon sector and its associated road-building in the western Amazon. Specifically, we document the (a) current panorama, including location and development status of all oil and gas discoveries, of the sector, and (b) current and future scenario of access (i.e. access road versus roadless access) to discoveries. We present an updated 2014 western Amazon hydrocarbon map illustrating that oil and gas blocks now cover 733 414 km(2), an area much larger than the US state of Texas, and have been expanding since the last assessment in 2008. In terms of access, we documented 11 examples of the access road model and six examples of roadless access across the region. Finally, we documented 35 confirmed and/or suspected untapped hydrocarbon discoveries across the western Amazon. In the Discussion, we argue that if these reserves must be developed, use of the offshore inland model-a method that strategically avoids the construction of access roads-is crucial to minimizing ecological impacts in one of the most globally important conservation regions

Zona Intangible Tagaeri Taromenane y Expansion de las Fronteras Hidrocarburifera

El Estado Ecuatoriano en 1999 se ha comprometido en delimitar una Zona Intangible para los pueblos en aislamiento Tagaeri Taromenane, que deber\ueda vedar \u201ca perpetuidad a todo tipo de actividad extractiva\u201d. Pero hay una movilidad de los pueblos en aislamiento y se asiste a una movilidad de la frontera petrolera. Este trabajo utilizando el papel de la escala (cartogr\ue1fica y geogr\ue1fica) y su implicaciones cognitivas ofrece un recorrido en cuatro miradas sobre lo que esta aconteciendo al redor, cerca, dentro la Zona Intangible, desde una visi\uf3n continental hasta el detalle de su historia y su perimetracion. Las herramientas cartogr\ue1fica y geogr\ue1fica nos ayudan a visualizar el hoy y imaginar el ma\uf1ana, sabiendo que el destino de este rinc\uf3n de la Amazonia no esta necesariamente definido: se trata de una regi\uf3n a elevada complexidad territorial con la potencialidad de articular una red entre \ue1reas protegidas, territorios ind\uedgenas y corredores ecol\uf3gicos culturales, recorriendo rutas alternativas de desarrollo local

Measuring supermassive black holes with gas kinematics - II. The LINERs IC 989, NGC 5077, and NGC 6500

We present results from a kinematical study of the gas in the nucleus of a sample of three LINER galaxies, obtained from archival HST/STIS long-slit spectra. We found that, while for the elliptical galaxy NGC 5077, the observed velocity curves are consistent with gas in regular rotation around the galaxy's center, this is not the case for the two remaining objects. By modeling the surface brightness distribution and rotation curve from the emission lines in NGC 5077, we found that the observed kinematics of the circumnuclear gas can be accurately reproduced by adding to the stellar mass component a black hole mass of M_bh = 6.8 (-2.8,+4.3) 10**8 M_sun (uncertainties at a 1 sigma level); the radius of its sphere of influence (R_sph ~ 0".34) is well-resolved at the HST resolution. The BH mass estimate in NGC 5077 is in fairly good agreement with both the M_bh-M_bul (with an upward scatter of ~ 0.4 dex) and M_bh-sigma correlations (with an upward scatter of 0.5 dex in the Tremaine et al. form and essentially no scatter using the Ferrarese et al. form) and provides further support for the presence of a connection between the ``residuals'' from the M_bh-sigma correlation and the bulge effective radius. This indicates the presence of a black hole's ``fundamental plane'' in the sense that a combination of at least sigma and R_e drives the correlations between M_bh and host bulge properties.Comment: Accepted for publication in A&

Liver transplantation for viral hepatitis in 2015

Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease and for patients with liver cell cancer related to liver disease. Acute and chronic liver diseases related to hepatitis viruses are between the main indications for liver transplantation. The risk of viral reinfection after transplantation is the main limiting factor in these indications. Before the availability of antiviral prophylaxis, hepatitis B virus (HBV) recurrence was universal in patients who were HBV DNA-positive before transplantation. The natural history of recurrent HBV was accelerated by immunosuppression, and it progressed rapidly to graft failure and death. Introduction of post-transplant prophylaxis with immunoglobulin alone first, and associated to antiviral drugs later, drastically reduced HBV recurrence, resulting in excellent long-term outcomes. On the contrary, recurrence of hepatitis C is the main cause of graft loss in most transplant programs. Overall, patient and graft survival after LT for hepatitis C virus (HCV)-associated cirrhosis is inferior compared with other indications. However, successful pretransplant or post transplant antiviral therapy has been associated with increased graft and overall survival. Until recently, the combination of pegylated interferon and ribavirin was the standard of care for the treatment of patients with chronic hepatitis C. Highly active antiviral compounds have been developed over the past decade, thanks to new in vitro systems to study HCV entry, replication, assembly, and release