MicroRNA Role in Thyroid Cancer Development

MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3′ noncoding region of the messenger RNA targets inducing their cleavage or blocking the protein translation. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, and cell maintenance and differentiation. Their deregulation can predispose to diseases and cancer. miRNA expression has been demonstrated to be deregulated in many types of human tumors, including thyroid cancers, and could be responsible for tumor initiation and progression. In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development

Multiple endocrine neoplasia type 1

Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine pancreas and anterior pituitary, and characterised by a very high penetrance and an equal sex distribution. It occurs in approximately one in 30,000 individuals. Two different forms, sporadic and familial, have been described. The sporadic form presents with two of the three principal MEN1-related endocrine tumours (parathyroid adenomas, entero-pancreatic tumours and pituitary tumours) within a single patient, while the familial form consists of a MEN1 case with at least one first degree relative showing one of the endocrine characterising tumours. Other endocrine and non-endocrine lesions, such as adrenal cortical tumours, carcinoids of the bronchi, gastrointestinal tract and thymus, lipomas, angiofibromas, collagenomas have been described. The responsible gene, MEN1, maps on chromosome 11q13 and encodes a 610 aminoacid nuclear protein, menin, with no sequence homology to other known human proteins. MEN1 syndrome is caused by inactivating mutations of the MEN1 tumour suppressor gene. This gene is probably involved in the regulation of several cell functions such as DNA replication and repair and transcriptional machinery. The combination of clinical and genetic investigations, together with the improving of molecular genetics knowledge of the syndrome, helps in the clinical management of patients. Treatment consists of surgery and/or drug therapy, often in association with radiotherapy or chemotherapy. Currently, DNA testing allows the early identification of germline mutations in asymptomatic gene carriers, to whom routine surveillance (regular biochemical and/or radiological screenings to detect the development of MEN1-associated tumours and lesions) is recommended

PEWARISAN NILAI ETIS DAN ESTETIS DALAM TARI SILAT GELOMBANG DI MASYARAKAT SIMEULUE, ACEH

ABSTRAK Penelitian ini bertujuan untuk mengetahui pewarisan nilai etis dan estetis dalam tari Silat Gelombang di masyarakat Simeulue Provinsi Aceh. Penelitian ini menggunakan paradigma kualitatif, dengan metode Sejarah dan pendekatan multidisiplin dengan kajian Etnokoreologi sebagai grand teori dibantu dengan disiplin ilmu lain seperti Folklore, Nilai dan teori Pendidikan Informal untuk mengungkapkan proses pewarisan nilai dalam tari Silat Gelombang di lingkungan keluarga dan masyarakat. Teknik pengumpulan data dengan observasi, wawancara, dokumentasi dan studi pustaka. Hasil penelitian ini memberi informasi mengenai pewarisan tari Silat Gelombang yang mengandung nilai etis (sosial dan kepribadian) bersumber dari Nandong, Nanga-nanga, Hadih Majah sebagai sumber nilai yang diyakini masyarakat Simeulue, Aceh dan nilai estetis tari Silat Gelombang melalui filosofi teks tari kepada masyarakat Simeulue, Aceh khususnya di lingkungan keluarga dan masyarakat. Kata Kunci: Pewarisan, Nilai Etis, Nilai Estetis, Tari Silat Gelombang, Masyarakat Simeulue, Aceh. ABSTRACT This study aimed to find out the inheritance of ethical and esthetical value in Silat Gelombang dance among Simeulue people in Aceh Province. This study used qualitative paradigm, with History method and multidisciplinary approach with Ethnochoreology as grand theory aided by another discipline knowledge such as Folklore, Value and Informal Education Theory to reveal the process of values inheritance in Silat Gelombang dance in environment and society. Data collection technique by observation, interview, documentation, and literature study. This study result gave information about the inheritance of Silat Gelombang dance which contain ethical value (social and personality) sourced from Nandong, Nanga-nanga, Hadih Majah as source of value believed by Simeulue people, Aceh and esthetical value of Silat Gelombang dance through dance text philosophy to Simeulue people, Aceh particularly in family and society environment. Keywords: Inheritance, Ethical Value, Esthetical Value, Silat Gelombang Dance, Simeulue People, Aceh

Bio-Polyethylene-Based Composites Reinforced with Alkali and Palmitoyl Chloride-Treated Coffee Silverskin

[EN] This work investigates the feasibility of using coffee silverskin (CSS) as a reinforcing agent in biobased polyethylene (BioPE) composites, by adding it in bulk and thin film samples. The effect of two different treatments, alkali bleaching (CSS_A) and esterification with palmitoyl chloride (CSS_P), on mechanical, thermal, morphological and water absorption behavior of produced materials at different CSS loading (10, 20 and 30 wt %) was investigated. A reactive graft copolymerization of BioPE with maleic anhydride was considered in the case of alkali treated CSS. It was found that, when introduced in bulk samples, improvement in the elastic modulus and a reduction in strain at maximum stress were observed with the increase in CSS fraction for the untreated and treated CSS composites, while the low aspect ratio of the CSS particles and their poor adhesion with the polymeric matrix were responsible for reduced ductility in films, decreasing crystallinity values and reduction of elastic moduli. When CSS_A and CSS_P are introduced in the matrix, a substantial reduction in the water uptake is also obtained in films, mainly due to presence of maleated PE, that builds up some interactions to eliminate the amounts of OH groups and hydrophobized CSS, due to the weakened absorption capacity of the functionalized CSS.This research was partially funded by the Ministry of Science, Innovation, and Universities (MICIU) project number MAT2017-84909-C2-2-R. D.G.G. wants to thank the Universitat Politècnica de València for financial support through a postdoctoral contract [PAID-10-18].Dominici, F.; Garcia-Garcia, D.; Fombuena, V.; Luzi, F.; Puglia, D.; Torre, L.; Balart, R. (2019). Bio-Polyethylene-Based Composites Reinforced with Alkali and Palmitoyl Chloride-Treated Coffee Silverskin. Molecules. 24(17):1-14. https://doi.org/10.3390/molecules24173113S1142417Carbonell-Verdú, A., García-García, D., Jordá, A., Samper, M. D., & Balart, R. (2015). Development of slate fiber reinforced high density polyethylene composites for injection molding. Composites Part B: Engineering, 69, 460-466. doi:10.1016/j.compositesb.2014.10.026Zhang, H. (2014). Effect of a novel coupling agent, alkyl ketene dimer, on the mechanical properties of wood–plastic composites. Materials & Design, 59, 130-134. doi:10.1016/j.matdes.2014.02.048Garcia-Garcia, D., Carbonell-Verdu, A., Jordá-Vilaplana, A., Balart, R., & Garcia-Sanoguera, D. (2016). 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Durability assessment of soft elastomeric capacitor skin for SHM of wind turbine blades

Renewable energy production has become a key research driver during the last decade. Wind energy represents a ready technology for large-scale implementation in locations all around the world. While important research is conducted to optimize wind energy production efficiency, a critical issue consists of monitoring the structural integrity and functionality of these large structures during their operational life cycle. This paper investigates the durability of a soft elastomeric capacitor strain sensing membrane, designed for structural health monitoring of wind turbines, when exposed to aggressive environmental conditions. The sensor is a capacitor made of three thin layers of an SEBS polymer in a sandwich configuration. The inner layer is doped with titania and acts as the dielectric, while the external layers are filled with carbon black and work as the conductive plates. Here, a variety of samples, not limited to the sensor configuration but also including its dielectric layer, were fabricated and tested within an accelerated weathering chamber (QUV) by simulating thermal, humidity, and UV radiation cycles. A variety of other tests were performed in order to characterize their mechanical, thermal, and electrical performance in addition to their solar reflectance. These tests were carried out before and after the QUV exposures of 1, 7, 15, and 30 days. The tests showed that titania inclusions improved the sensor durability against weathering. These findings contribute to better understanding the field behavior of these skin sensors, while future developments will concern the analysis of the sensing properties of the skin after aging

Time makes histone H3 modifications drift in mouse liver

To detect the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. The comparison of different age profiles of histone H3 marks revealed global redistribution of histone H3 modifications with time, in particular in intergenic regions and near transcription start sites, as well as altered correlation between the profiles of different histone modifications. Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions

Design and Characterization of PLA Bilayer Films Containing Lignin and Cellulose Nanostructures in Combination With Umbelliferone as Active Ingredient

Poly (lactic acid) (PLA) bilayer films, containing cellulose nanocrystals (CNC) or lignin nanoparticles (LNP) and Umbelliferone (UMB) were extruded and successfully layered by thermo-compression starting from monolayer films. Lignocellulosic nanostructures were used in PLA based film as nanofillers at 3 wt.%, while UMB was used as active ingredient (AI) at 15 wt.%. The effects of processing techniques, presence, typology and content of lignocellulosic nanoparticles have been analyzed and thermal, morphological, mechanical and optical characterization of PLA nanocomposites have been made.Furthermore, X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FTIR) studies evaluated the presence of nanofillers and AI at chemical level. Bilayer formulations showed a good interfacial adhesion and improved stress at break with respect of PLA monolayers, although they were less stretchable and transparent. Data obtained from thermal, colorimetric and transparency investigations underlined that the presence of lignocellulosic nanofillers and AI in PLA monolayer and bilayer films induced relevant alterations in terms of overall color properties and thermal stability, while antioxidant activity of umbelliferone was enhanced by the addition of lignin in produced materials.Fil: Iglesias Montes, Magdalena Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Luzi, Francesca. Università di Perugia; ItaliaFil: Dominici, Franco. Università di Perugia; ItaliaFil: Torre, Luigi. Università di Perugia; ItaliaFil: Cyras, Viviana Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Manfredi, Liliana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Puglia, Debora. Università di Perugia; Itali