Infertility and assisted reproduction: legislative and cultural evolution in Italy. Infertilità e procreazione assistita: evoluzione legislativa e culturale in Italia

The social representation of the infertility coming out from the national newspapers has been explored in relation to the enactment of the Law 40/2004 and the 2005 referendum. All the articles (n=731), published in the last 15 years by the highest circulation Italian newspapers, have been collected in a corpus (token=360345) that underwent a multivariate analysis of textual data. Results show a difficulty in complementing together the mind and the body. The “biologic” is represented as the place of the technical and medical intervention while the “psycho-social” is conceived as the place of the family storytelling of the personal experiences of infertility and the public ethical debate on it. Before the law, newspapers deal with the theme of the family experience probably supporting the law enactment. After the referendum this thematic is dismissed and the theme of infertility as a pathology to treat emerges, bringing back infertility to the medical issu

Self-immolative linkers in polymeric delivery systems

There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination

Museo narrante: the Foce Sele Hera sanctuary virtual museum

The communication of one century of archaeological research at the Foce Sele Hera Sanctuary has been the main reason for the creation of a new virtual museum, for which a name that represents a museological approach, “Museo Narrante”, i.e. the Museum that tells stories has been chosen. The museum is conceived as a museum without objects, interactive, multi-sensorial, and multi-medial. Its main issues are: i. minor sites valorization; ii. museums as territorial communication networks; iii. levels of reliability; iv. multiple interpretation. The overall intent is to give viewers evidence and argument instead of a prepackaged explanation. This paper shows how this concept guided the whole exhibition, with the realization of different tools to present to the public the stories of the Foce Sele Hera Sanctuary and the archaeological investigation of the area in a new way

On the Termination of Logic Programs with Function Symbols

Recently there has been an increasing interest in the bottom-up evaluation of the semantics of logic programs with complex terms. The main problem due to the presence of functional symbols in the head of rules is that the corresponding ground program could be infinite and that finiteness of models and termination of the evaluation procedure is not guaranteed. This paper introduces, by deeply analyzing program structure, new decidable criteria, called safety and Gamma-acyclicity, for checking termination of logic programs with function symbols under bottom-up evaluation. These criteria guarantee that stable models are finite and computable, as it is possible to generate a finitely ground program equivalent to the source program. We compare new criteria with other decidable criteria known in the literature and show that the Gamma-acyclicity criterion is the most general one. We also discuss its application in answering bound queries

Dominance-based rough set approach and analytic network process for assessing urban transformation scenarios

For half a century, the significant development of intensive farming has led to a massive use of products such as pesticides. The excessive use of these substances has contaminated surface water and groundwater. Drinking water extraction points have also had to be abandoned. Some thirty years ago, in the southwest of France, a group of farmers decided to improve their farming methods, as well as developing new Best Environmental Practices, such as grass strips along streams and riparian forests. By combining the use of ELECTRE TRI-C multi-criteria model with a GIS, we were able to characterise the contribution of each farming area to the risk of surface water contamination with pesticides. We also assessed the effectiveness of different environmental practices. We found that the use of Best Environmental Practices led to a reduction in the risk of pesticides transfer. This methodology re-enforces decision support tools for water resource managers and agricultural and environmental stakeholders

Prediction of hearing recovery in sudden deafness treated with intratympanic steroids

The present study aims to obtain a probability model allowing the prediction of the auditory recovery in patients affected by sudden sensorineural hearing loss treated exclusively with intratympanic steroids. A monocentric retrospective chart review of three-hundred eighty-one patients has been performed. A Probit model was used to investigate the correlation between the success of the treatment (marked or total recovery according to Furuashi's criteria), and the delay between the onset of disease and the beginning of therapy. The age of the patients and the audiometric curve shapes were included in the analysis. Results show that delay is negatively correlated with the variable success. Considering the entire sample, each day of delay decreases by 3% the probability of success. The prediction model shows that for every day that passes from the onset of the disease the probability of success declines in absence of the medical treatment, hence we conclude that early treatment is strongly recommended

The geological characterization of landscape in majjor TV Series: a suggested approach to involve the public in the geological heritage promotion.

The characterization of natural and cultural heritage using popular entertainment, such as TV movies and series, can become an effective and original way to involve society in protecting territory and enhancing local development, thanks to the dissemination of knowledge. The aim is to make the complex aspects of landscape related to its geological and ecological assessment understandable to the public. The tools here proposed are the episodes of the TV series “Inspector Montalbano” filmed in Sicily. The stories, written by Andrea Camilleri, are located in Sicily (the biggest Italian island in the southern Mediterranean Sea), in particular with some World Heritage Sites. The natural and cultural landscapes, which provide fascinating scenery to the films, represent a meaning in the representation of the plot. At the same time, if recognized and understood, they become part of the cultural heritage of each component of the local community and of society. The cognitive process activates a virtuous circle revitalizing the links between humanity and environment. Moreover, it promotes a creative participation of the public in new policies, oriented towards sustainable development, and tourism—especially geotourism and ecotourism—becomes an important resource, especially in these times of crisis

Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells

Β-blockers (BB) are a primary treatment for chronic heart disease (CHD), resulting in prognostic and symptomatic benefits. Cardiac cell therapy represents a promising regenerative treatment and, for autologous cell therapy, the patients clinical history may correlate with the biology of resident progenitors and the quality of the final cell product. This study aimed at uncovering correlations between clinical records of biopsy-donor CHD patients undergoing cardiac surgery and the corresponding yield and phenotype of cardiospheres (CSs) and CS-derived cells (CDCs), which are a clinically relevant population for cell therapy, containing progenitors. We describe a statistically significant association between BB therapy and improved CSs yield and CDCs phenotype. We show that BB-CDCs have a reduced fibrotic-like CD90 + subpopulation, with reduced expression of collagen-I and increased expression of cardiac genes, compared to CDCs from non-BB donors. Moreover BB-CDCs had a distinctive microRNA expression profile, consistent with reduced fibrotic features (miR-21, miR-29a/b/c downregulation), and enhanced regenerative potential (miR-1, miR-133, miR-101 upregulation) compared to non-BB. In vitro adrenergic pharmacological treatments confirmed cytoprotective and anti-fibrotic effects of β1-blocker on CDCs. This study shows anti-fibrotic and pro-commitment effects of BB treatment on endogenous cardiac reparative cells, and suggests adjuvant roles of β-blockers in cell therapy applications

Enzymatically-triggered, isothermally responsive polymers: re-programming poly(oligoethylene glycols) to respond to phosphatase

Polymers which can respond to externally applied stimuli have found much application in the biomedical field due to their (reversible) coil–globule transitions. Polymers displaying a lower critical solution temperature are the most commonly used, but for blood-borne (i.e., soluble) biomedical applications the application of heat is not always possible, nor practical. Here we report the design and synthesis of poly(oligoethylene glycol methacrylate)-based polymers whose cloud points are easily varied by alkaline phosphatase-mediated dephosphorylation. By fine-tuning the density of phosphate groups on the backbone, it was possible to induce an isothermal transition: A change in solubility triggered by removal of a small number of phosphate esters from the side chains activating the LCST-type response. As there was no temperature change involved, this serves as a model of a cell-instructed polymer response. Finally, it was found that both polymers were non cytotoxic against MCF-7 cells (at 1 mg·mL–1), which confirms promise for biomedical applications