Renovation of Public Lighting Systems in Cultural Landscapes: Lighting and Energy Performance and Their Impact on Nightscapes

The technological innovation in the field of lighting and the need to reduce energy consumption connected to public lighting are leading many municipalities to undertake the renewal of public lighting systems, by replacing the existing luminaires with LED technologies. This renovation process is usually aimed at increasing energy efficiency and reducing maintenance costs, whist improving the lighting performance. To achieve these results, the new luminaires are often characterised by a luminous flux distribution much more downward oriented, which may remarkably influence and alter the perception of the night image of the sites. In this study the implications of the renovation of public lighting systems in terms of lighting and energy performance as well as the effects relating to the alteration of the night image, in historical contexts characterized by significant landscape value, are analysed. Results, along with demonstrating the positive effect that more sustainable and energy efficient lighting systems may have on the lighting performance and energy consumptions of public lighting systems, evidences the impact they may have on the alteration of the nocturnal image

Nutrient availability links mitochondria, apoptosis, and obesity

Mitochondria are the dominant source of the cellular energy requirements through oxidative phosphorylation, but they are also central players in apoptosis. Nutrient availability may have been the main evolutionary driving force behind these opposite mitochondrial functions: production of energy to sustain life and release of apoptotic proteins to trigger cell death. Here, we explore the link between nutrients, mitochondria and apoptosis with known and potential implications for age‐related decline and metabolic syndromes

Bioseparation of Four Proteins from Euphorbia characias Latex: Amine Oxidase, Peroxidase, Nucleotide Pyrophosphatase/Phosphodiesterase, and Purple Acid Phosphatase

This paper deals with the purification of four proteins from Euphorbia characias latex, a copper amine oxidase, a nucleotide pyrophosphatase/phosphodiesterase, a peroxidase, and a purple acid phosphatase. These proteins, very different in molecular weight, in primary structure, and in the catalyzed reaction, are purified using identical preliminary steps of purification and by chromatographic methods. In particular, the DEAE-cellulose chromatography is used as a useful purification step for all the four enzymes. The purification methods here reported allow to obtain a high purification of all the four proteins with a good yield. This paper will give some thorough suggestions for researchers busy in separation of macromolecules from different sources

Pistacia lentiscus: phytochemistry and anti-diabetic properties

Pistacia lentiscus L. (P. lentiscus) is an evergreen shrub (Anacardiaceae family) primarily found in the Mediterranean region. The plant has been thoroughly characterized, resulting in a high concentration of bioactive compounds as flavonoids and phenolics. Moreover, P. lentiscus was revealed to possess a great nutritional and industrial importance because of its variety of biological activities, including antibacterial, anti-inflammatory, anti-atherogenic and antioxidant properties. Many of its beneficial health properties and applications date back to antiquity, and the European Medicines Agency officially acknowledged it as an herbal medicinal product. Indeed, it is widely employed in conventional medicine to treat several diseases, including type 2 diabetes (T2D). On this basis, this review aims to summarize and describe the chemical composition of different parts of the plant and highlight the potential of P. lentiscus, focusing on its antidiabetic activities. The plant kingdom is drawing increasing attention because of its complexity of natural molecules in the research of novel bioactive compounds for drug development. In this context, P. lentiscus demonstrated several in vitro and in vivo antidiabetic effects, acting upon many therapeutic T2D targets. Therefore, the information available in this review highlighted the multitarget effects of P. lentiscus and its great potential in T2D treatment

low enthalpy geothermal systems for air conditioning a case study in the mediterranean climate

Abstract This paper presents a preliminary evaluation of the technical and economic feasibility of a low-enthalpy geothermal system for air conditioning and its integration with other systems, including a photovoltaic plant and an electrical storage system. The pilot building is a research center located in the southern side of the Mediterranean basin (Sardinia, Italy). Preliminarily, the main geological, hydrogeological and geothermal characteristics of the area were analyzed. Then, an energetic assessment of the building and its plants was performed. The hourly production of a photovoltaic plant already designed for the building was assessed. To improve the energy efficiency and the thermal energy self-consumption, an alternative thermal generation plant was proposed to replace the existing air conditioning system: a water-water heat pump coupled with a low-enthalpy geothermal probe (vertical configuration), to be embedded into the ground or placed into an existing groundwater well. The feasibility of electric storage was evaluated by considering a system capacity of 100 kWh to temporarily store and self-consume the electricity overproduced by the photovoltaic plant. A preliminary economic assessment showed the viability of the photovoltaic system. The 100 kWh-capacity electric storage will increase the self-production percentage, but it is not economically affordable. The replacement of the current air-water heat pumps with one water-water heat pump will be economically convenient if coupled with a groundwater geothermal probe, but the solution of a vertical probe embedded into the ground is unsustainable, due to high drilling costs

Euphorbia characias: Phytochemistry and Biological Activities

The aim of this review is to summarize all the compounds identified and characterized from Euphorbia characias, along with the biological activities reported for this plant. Euphorbia is one of the greatest genera in the spurge family of Euphorbiaceae and includes different kinds of plants characterized by the presence of milky latex. Among them, the species Euphorbia characias L. is an evergreen perennial shrub widely distributed in Mediterranean countries. E. characias latex and extracts from different parts of the plant have been extensively studied, leading to the identification of several chemical components such as terpenoids, sterol hydrocarbons, saturated and unsaturated fatty acids, cerebrosides and phenolic and carboxylic acids. The biological properties range between antioxidant activities, antimicrobial, antiviral and pesticidal activities, wound-healing properties, anti-aging and hypoglycemic properties and inhibitory activities toward target enzymes related to different diseases, such as cholinesterases and xanthine oxidase. The information available in this review allows us to consider the plant E. characias as a potential source of compounds for biomedical research

Insegnanti e pandemia

A partire da febbraio 2020, l'emergenza sanitaria causata dal COVID-19 ha portato a provvedimenti di contenimento della diffusione del virus con restrizioni della mobilità dei cittadini, confinamento e chiusura delle scuole di ogni ordine e grado su tutto il territorio nazionale. A causa della chiusura delle scuole, inoltre, gli insegnanti hanno dovuto attivare repentinamente modalità di Didattica a Distanza (DaD), senza alcun tipo di preparazione o formazione preliminare. Il presente report illustra i principali risultati di un'indagine svolta durante la chiusura delle scuole che ha coinvolto più di 1000 insegnanti italiani. L'obiettivo era studiare se e come tale richiesta improvvisa di modifiche al proprio lavoro, la mancanza di competenze per l'insegnamento a distanza, unitamente alla condizione di confinamento, abbiano influito sul benessere psicologico e lavorativo e sul senso di autoefficacia degli e delle insegnanti

Benefits of Exercise with Mini Tennis in Intellectual Disabilities: Effects on Body Image and Psychopathology

The present study is aimed at evaluating the efficacy of an introductory mini tennis programme as a therapeutic aid in the psychosocial rehabilitation of participants affected by mild/moderate intellectual disability in semi-residential care

Hydroxy-3-Phenylcoumarins as Multitarget Compounds for Skin Aging Diseases: Synthesis, Molecular Docking and Tyrosinase, Elastase, Collagenase and Hyaluronidase Inhibition, and Sun Protection Factor

Skin aging is a progressive biological process of the human body, and it is not only time-dependent. Differently substituted 3-phenylcoumarins proved to efficiently inhibit tyrosinase. In the current work, new substitution patterns have been explored, and the biological studies were extended to other important enzymes involved in the processes of skin aging, as elastase, collagenase and hyaluronidase. From the studied series, five compounds presented inhibitory activity against tyrosinase, one compound against elastase, eight compounds against collagenase and two compounds against hyaluronidase, being five compounds dual inhibitors. The 3-(4 '-Bromophenyl)-5,7-dihydroxycoumarin (1) and 3-(3 '-bromophenyl)-5,7-dihydroxycoumarin (2) presented the best profiles against tyrosinase (IC50 = 1.05 mu M and 7.03 mu M) and collagenase (IC50 = 123.4 mu M and 110.4 mu M); the 3-(4 '-bromophenyl)-6,7-dihydroxycoumarin (4) presented a good inhibition against tyrosinase and hyaluronidase; the 3-(3 '-bromophenyl)-6,7-dihydroxycoumarin (5) showed an effective tyrosinase and elastase inhibition; and 6,7-dihydroxy-3-(3 '-hydroxyphenyl)coumarin (11) presented a dual profile inhibition against collagenase and hyaluronidase. Furthermore, considering the overall activities tested, compounds 1 and 2 proved to be the most promising anti-aging compounds. These compounds also showed to have a photo-protective effect, without being cytotoxic to human skin keratinocyte cells. To predict the binding site with the target enzymes, computational studies were also carried out