Business model innovation in SMEs engaging in innovation ecosystems. A decoupling perspective

Digital technologies have been increasingly affecting our day-to-day activities, drastically reshaping markets and society. The diffusion of new digital technologies\u2014such as social media, cloud computing, mobile computing, 3D printing, and big-data analytics \u2013 is posing firms to challenges, creating opportunities to develop radically new business models. However, despite the growing interest towards this issue, the contribute of digitalisation from the perspective of small and medium-sized enterprises (SMEs) is still such an under-investigated topic. SMEs are considered a driving force in most national economies, contributing heavily to employment, innovation and economic growth, but at the same time they often suffer from lack of both financial and human resources. These weaknesses may be compensated by the inflow and outflow of knowledge and capital boosted by technological innovation and participation within innovation ecosystems. The aim of this paper is to understand, through the lens of the institutional theory, how both the relationships established within the ecosystem and the internal organizational capabilities of SMEs impact on business model innovation thanks to the adoption of digital technologies such as Internet of things, big data, and open data. To do so the authors carried out an embedded case study on an Italian Industry 4.0 project which involved several actors (e.g. food SMEs, universities, technology consulting companies, and Piedmont Region). First findings on this ongoing research show that innovation ecosystems could represent a strong driver for developing an innovative business model oriented to value co-creation provided that SMEs already own distinctive dynamic capabilities. Without these capabilities it would be difficult to fully exploit the digital opportunities arising from the relationships among the heterogeneous actors which are part of the project

Mirta Yáñez - L'hotel e altre poesie: Traduzione di Francesca Gambardella in collaborazione con Antonella Cancellier, Francesca Bressan, Isabella De Bernardi ed Emanuela Pisani

Mirta Yáñez (La Habana 1947) è una poetessa, narratrice e saggista particolarmente impegnata nello studio e riscatto della letteratura femminile cubana. È membro della Academia Cubana de la Lengua e nel 2018 ha ricevuto il Premio Nacional de Literatura

Eliseo Diego - Il primo discorso e altre poesie: Traduzioni di Francesca Bressan, Isabella De Bernardi ed Emanuela Pisani in collaborazione con Antonella Cancellier e Francesca Gambardella

Gabriel García Márquez lo considerava uno dei più grandi poeti in lingua spagnola, ma in Patria il rimpianto Eliseo Diego (L’Avana 1920-Città de Messico 1994) è anche ricordato come eccellente anglista e sensibile scrittore per l’infanzia. Tra gli animatori di Orígenes - rivista letteraria fondata nel 1944 da José Lezama Lima e José Rodríguez Feo - venne insignito del Premio Nazionale di Letteratura nel 1986

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged recently as valuable anticancer agents. Here, we have designed, synthesized, and tested new Hh inhibitors taking advantage by the highly versatile and privileged isoflavone scaffold. The introduction of specific substitutions on the isoflavone's ring B allowed the identification of molecules targeting preferentially Smo or Gli1. Biological assays coupled with molecular modeling corroborated the design strategy, and provided new insights into the mechanism of action of these molecules. The combined administration of two different isoflavones behaving as Smo and Gli antagonists, respectively, in primary medulloblastoma (MB) cells highlighted the synergistic effects of these agents, thus paving the way to further and innovative strategies for the pharmacological inhibition of Hh signaling

Effects of the COVID-19 Pandemic on Brief Resolved Unexplained Events (BRUEs) in Children: A Comparative Analysis of Pre-Pandemic and Pandemic Periods

Background: Brief Resolved Unexplained Events (BRUEs), formerly known as Apparent Life-Threatening Events (ALTEs), are concerning episodes of short duration (typically <1 min) characterized by a change in breathing, consciousness, muscle tone, and/or skin color. In some cases, SARS-CoV-2 infection has been associated with episodes of BRUEs in previously healthy children. This study aimed to compare the demographic, respiratory, perinatal, and infectious characteristics in children affected by BRUEs before the COVID-19 pandemic and after the spread of SARS-CoV-2. Methods: We conducted a retrospective observational study covering January 2018 to March 2020 (pre-COVID-19) and April 2023 (during the ongoing COVID-19 pandemic). Collected variables included clinical information during pregnancy and neonatal details of children with BRUEs. Results: The number of children in the pre-COVID-19 period was 186 (41%); after the emergence and spread of SARS-CoV-2 this number was 268 (59%). The risk of infection at birth for children developing BRUEs was higher during the pandemic. Children were less likely to have ongoing symptomatic infection during BRUEs during the pandemic (coefficient B = 0.783; p = 0.009). Respiratory symptoms during BRUEs were more frequent during the pandemic (coefficient B = 0.654; p = 0.052). Fever during BRUEs was less likely during the pandemic (coefficient B = -0.465, p = 0.046). Conclusions: These findings could have significant clinical implications for managing children with BRUEs during the COVID-19 pandemic

Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks

The resistance of leukemic stem cells in response to targeted therapies such as tyrosine kinase inhibitors (TKIs) relies on the cooperative activity of multiple signaling pathways and molecules, including TGFβ, AKT, and FOXO transcription factors (TFs). B cell lymphoma 6 (BCL6) is a transcriptional repressor whose translocation or mutation is associated with diffuse large BCL. New data now show that BCL6 is critical for the maintenance of leukemias driven by the BCR-ABL translocation (Philadelphia chromosome), suggesting that BCL6 is a novel, targetable member of the complex signaling pathways critical for leukemic stem cell survival

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key event remains limited. Here, we show that the Itch/β-arrestin2 complex binds SuFu and induces its Lys63-linked polyubiquitylation without affecting its stability. This process increases the association of SuFu with Gli3, promoting the conversion of Gli3 into a repressor, which keeps Hh signalling off. Activation of Hh signalling antagonises the Itch-dependent polyubiquitylation of SuFu. Notably, different SuFu mutations occurring in medulloblastoma patients are insensitive to Itch activity, thus leading to deregulated Hh signalling and enhancing medulloblastoma cell growth. Our findings uncover mechanisms controlling the tumour suppressive functions of SuFu and reveal that their alterations are implicated in medulloblastoma tumorigenesis