Genderdidaktik: von der universitären Selbstverpflichtung zur Schlüsselkompetenz

Genderkompetenz ist zu einem wichtigen Schlagwort moderner Hochschulpolitik geworden. Neben den weitreichenden Gleichstellungsmaßnahmen, die in den letzten Jahren an vielen Universitäten eingeführt wurden, ist eine umfassende genderdidaktische Weiterbildung der Lehrenden an Universitäten ein wichtiger, bislang vergleichsweise wenig beachteter Baustein in diesem Prozess. Der Aufsatz diskutiert, welchen Beitrag genderdidaktische Maßnahmen für mehr Sensibilität und methodische Kompetenz des wissenschaftlichen Personals an Hochschulen und für ein Mehr an moderner Wissenschaftskultur leisten können. Dazu zählen vor allem die Sensibilisierung für die Erweiterung des Curriculums um genderrelevante Aspekte, ein bewusster Umgang mit Sprache und Bildern in der Lehre sowie eine unter dem Aspekt der Genderproblematik reflektierte Unterrichtsmethodik

Modelling aspects of oviduct fluid formation in vitro

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical environment remain rather poorly defined. This study uses an in vitro preparation of the bovine oviduct epithelium to investigate the formation and composition of in vitro-derived oviduct fluid (ivDOF) within a controlled environment. We confirm the presence of oviduct-specific glycoprotein 1 in ivDOF and show that the amino acid and carbohydrate content resembles that of previously reported in vivo data. In parallel, using a different culture system, a panel of oviduct epithelial solute carrier genes and the corresponding flux of amino acids within ivDOF in response to steroid hormones were investigated. We next incorporated fibroblasts directly beneath the epithelium. This dual culture arrangement represents more faithfully the in vivo environment and impacts on ivDOF composition. Lastly, physiological and pathophysiological endocrine states were modelled and their impact on the in vitro oviduct preparation was evaluated. These experiments help clarify the dynamic function of the oviduct in vitro and suggest a number of future research avenues, such as investigating epithelial-fibroblast interactions, probing the molecular aetiologies of subfertility and optimising embryo culture media

Treatment of Resistant Fever: New Method of Local Cerebral Cooling

Background: Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever. Methods: Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour8. Results: The brain, blood, and urinary bladder temperatures decreased significantly from hour0 to a minimum in hour5 (P<0.01). After hour5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted. Conclusion: This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patient

Predictors of increasing BMI during the course of diabetes in children and adolescents with type 1 diabetes: data from the German/Austrian DPV multicentre survey

Objective: Increased weight gain has been reported prior to disease onset (accelerator hypothesis) and as a side effect of intensified insulin therapy in type 1 diabetes (T1D). Paediatric studies are complicated by the age-dependency and gender-dependency of BMI, and also by a trend towards obesity in the general population. The aim of this study was to evaluate factors related to the increase in BMI during the course of diabetes in children and adolescents with T1D in a large multicentre survey. Design: Within the DPV database (Diabetespatienten Verlaufsdokumentation) a standardised, prospective, computer-based documentation programme, data of 53 108 patients with T1D, aged <20 years, were recorded in 248 centres. 12 774 patients (53% male, mean age 13.4+/-3.9, mean diabetes duration 4.7+/-3.0 years and mean age at diabetes onset 8.7+/-4.0 years) were included in this analysis. Population-based German reference data were used to calculate BMI-SDS and define overweight and obesity. Results: 12.5% of T1D patients were overweight and 2.8% were obese. Multiple longitudinal regression analysis revealed that female gender, low BMI at diabetes onset, intensified insulin therapy and higher insulin dose, as well as pubertal diabetes onset, long diabetes duration and onset in earlier calendar years among girls, were related to higher BMI-SDS increase during the course of diabetes (p<0.01; all). Conclusions: Intensified insulin regimen is associated with weight gain during T1D treatment, in addition to demographic variables. Optimisation of diabetes management, especially in females, might limit weight gain in order to reduce overweight and obesity together with comorbidities among paediatric T1D patients

Host–pathogen associations revealed by genotyping of European strains of Anaplasma phagocytophilum to describe natural endemic cycles

Background The zoonotic intracellular alpha-proteobacterium Anaplasma phagocytophilum is a tick-transmitted pathogen. The associations between vertebrate reservoirs and vectors are described as wide-ranging, and it was previously shown that the pathogenicity of A. phagocytophilum differs depending on the combination of pathogen variant and infected host species. This leads to the question of whether there are variations in particular gene loci associated with different virulence. Therefore, this study aims at clarifying existing host-variant combinations and detecting possible reservoir hosts. To understand these interactions, a complex toolset for molecular epidemiology, phylogeny and network theory was applied. Methods Sequences of up to four gene loci (msp4, msp2, groEL and 16S rRNA) were evaluated for different isolates from variable host species, including, for example, dogs, cattle and deer. Variant typing was conducted for each gene locus individually, and combinations of different gene loci were analysed to gain more detailed information about the genetic plasticity of A. phagocytophilum. Results were displayed as minimum spanning nets and correlation nets. Results The highest diversity of variants for all gene loci was observed in roe deer. In cattle, a reduced number of variants for 16S rRNA [only 16S-20(W) and 16S-22(Y)] but multiple variants of msp4 and groEL were found. For dogs, two msp4 variants [m4-20 and m4-2(B/C)] were found to be linked to different variants of the other three gene loci, creating two main combinations of gene loci variants. Cattle are placed centrally in the minimum spanning net analyses, indicating a crucial role in the transmission cycles by possibly bridging the vector-wildlife cycle to infections of humans and domestic animals. The minimum spanning nets confirmed previously described epidemiological cycles of the bacterium in Europe, showing separation of variants originating from wildlife animals only and a set of variants shared by wild and domestic animals. Conclusions In this comprehensive study of 1280 sequences, we found a high number of gene variants only occurring in specific hosts. Additionally, different hosts show unique but also shared variant combinations. The use of our four gene loci expand the knowledge of host–pathogen interactions and may be a starting point to predict future spread and infection risks of A. phagocytophilum in Europe

Searching for an Added Value of Precipitation in Downscaled Seasonal Hindcasts over East Africa: COSMO-CLM Forced by MPI-ESM

Downscaling of seasonal hindcasts over East Africa with the regional climate model (RCM) COSMO-CLM (CCLM), forced by the global climate model (GCM) and MPI-ESM, is evaluated. The simulations are done for five months (May to September) for a ten-year period (2000–2009), with the evaluation performed only for June to September. The dry years, 2002 and 2009, and the wet years, 2006 and 2007, are well captured by the models. By using ground based and satellite gridded observation data for evaluation it is found that both COSMO-CLM and MPI-ESM overestimate June to September precipitation over the Ethiopian highlands and in parts of the lowland with respect to all reference datasets. In addition we investigated the potential and real added value for both the RCM and the GCM hindcasts by upscaling (arithmetic mean) the precipitation resolution both in temporal and in spatial scales, over North Ethiopia (EN), South Ethiopia (ES), South Sudan (SS), and Sudan (S). Results inferred that using the RCM for seasonal forecast adds value in capturing extreme precipitation years, especially in the Ethiopian highlands. It is also found that the potential and relative potential added value decrease with decreasing the temporal resolution

Structural and functional connectivity between the lateral posterior-pulvinar complex and primary visual cortex in the ferret

The role of higher-order thalamic structures in sensory processing remains poorly understood. Here, we used the ferret (Mustela putorius furo) as a novel model species for the study of the lateral posterior-pulvinar complex (LP/pulvinar) and its structural and functional connectivity with area 17 (primary visual cortex, V1). We found reciprocal anatomical connections between the lateral part of the Lateral Posterior Nucleus of the LP/pulvinar (LPl) and V1. In order to investigate the role of this feedback loop between LPl and V1 in shaping network activity, we determined the functional interactions between LPl and supragranular, granular, and infragranular layers of V1 by recording multiunit activity (MUA) and local field potential (LFP). Coherence was strongest between LPl and supragranular V1 with the most distinct peaks in the delta and alpha frequency bands. Inter-area interaction measured by spike-phase coupling identified the delta frequency band dominated by infragranular V1 and multiple frequency bands that were most pronounced in supragranular V1. This inter-area coupling was differentially modulated by full-field synthetic and naturalistic visual stimulation. We also found that visual responses in LPl were distinct from the ones in V1 in terms of their reliability. Together, our data support a model of multiple communication channels between the LPl and layers of V1 that are enabled by oscillations in different frequency bands. This demonstration of anatomical and functional connectivity between LPl and V1 in ferrets provides a roadmap for studying the interaction dynamics during behavior and a template for identifying activity dynamics of other thalamic feedback loops

Resting state network topology of the ferret brain

Resting state functional magnetic resonance imaging (rsfMRI) has emerged as a versatile tool for non-invasive measurement of functional connectivity patterns in the brain. RsfMRI brain dynamics in rodents, non-human primates, and humans share similar properties; however, little is known about the resting state functional connectivity patterns in the ferret, an animal model with high potential for developmental and cognitive translational study. To address this knowledge-gap, we performed rsfMRI on anesthetized ferrets using a 9.4 tesla MRI scanner, and subsequently performed group-level independent component analysis (gICA) to identify functionally connected brain networks. Group-level ICA analysis revealed distributed sensory, motor, and higher-order networks in the ferret brain. Subsequent connectivity analysis showed interconnected higher-order networks that constituted a putative default mode network (DMN), a network that exhibits altered connectivity in neuropsychiatric disorders. Finally, we assessed ferret brain topological efficiency using graph theory analysis and found that the ferret brain exhibits small-world properties. Overall, these results provide additional evidence for pan-species resting-state networks, further supporting ferret-based studies of sensory and cognitive function

Early vs late histological confirmation of coeliac disease in children with new-onset type 1 diabetes

AIM Screening for coeliac disease in asymptomatic children with new-onset type 1 diabetes is controversial. The aim of this study was to analyse whether the confirmation of coeliac disease in children with new-onset type 1 diabetes and positive screening results can be postponed. METHODS This was a multicentre population-based cohort study based on the German/Austrian/Swiss/Luxembourgian Prospective Diabetes Follow-up Registry (Diabetes Patienten Verlaufsdokumentation [DPV]). Participants aged ≤18 years diagnosed with type 1 diabetes between 1995 and June 2021 and with elevated IgA tissue transglutaminase antibodies (anti-tTGA) at diabetes onset on screening for coeliac disease were included. We compared outcomes of participants with a diabetes duration of more than 1 year between those in whom coeliac disease was confirmed histologically within the first 6 months and those in whom coeliac disease was confirmed between 6 and 36 months after diabetes diagnosis. RESULTS Of 92,278 children and adolescents with a diagnosis of type 1 diabetes, 26,952 (29.2%) had documented anti-tTGA data at diabetes onset. Of these, 2340 (8.7%) had an elevated anti-tTGA level. Individuals who screened positive were younger (median age 9.0 vs 9.8 years, p<0.001) and more often female (53.1% vs 44.4%, p<0.001). A total of 533 participants (22.8% of those who screened positive) had a documented biopsy, of whom 444 had documented histological confirmation of coeliac disease. Of 411 participants with biopsy-proven coeliac disease within the first 36 months of diabetes and follow-up data, histological confirmation was performed in 264 (64.2%) within the first 6 months and in 147 (35.8%) between 6 and 36 months after diabetes onset. At follow-up (median diabetes duration 5.3 years and 5.1 years, respectively), estimated median HbA1c levels (62.8 mmol/mol vs 62.2 mmol/mol [7.9% vs 7.8%]), cardiovascular risk markers (lipids, rate of microalbuminuria, blood pressure), rates of acute diabetes complications (diabetic ketoacidosis, severe hypoglycaemia) and the proportions of participants reaching anti-tTGA levels within the normal range did not differ between groups. Participants with delayed histological confirmation of coeliac disease showed no negative effects on growth or weight gain during the observation period. CONCLUSIONS Our study suggests that the histological confirmation of coeliac disease in asymptomatic individuals with new-onset type 1 diabetes could be postponed

Da.zwischen: Musik erleben – Erleben vermitteln: Interinstitutionelle-interdisziplinäre-intermediale Arbeitstagung der Musikpädagogik 12.-13. Mai 2023: Tagungsband

Der vorliegende Tagungsband eröffnet Einblicke in ausgewählte Beiträge, Workshops, Gruppenimprovisationen und Performances der Arbeitstagung „DaZwischen 2023“: einer Initiative für eine interdisziplinäre musikpädagogische Begegnung von Lehrenden und Studierenden, Mitwirkenden und Teilnehmenden verschiedener Hochschulen und Universitäten. Das Dazwischen entfaltete sich zwischen den Disziplinen und Arbeitsfeldern und eröffnete sich in pädagogischen und spezifisch musikpädagogischen Aspekten. Im Kontext der Vermittlung des Ästhetischen, des ästhetischen Erlebens und der Intention, ästhetisches Erleben zu inszenieren, wurden unbestimmbare, widersprüchliche und ambivalente Zustände beschrieben und diskutiert. Geschieht Improvisation aktiv oder passiv, vollzieht sich Bildung in Freiheit oder intentional, was bewegt – oder lässt sich bewegen? Im DaZwischen erfüllt sich Unerfüllbares, verwirklicht sich Unplanbares. Der vorliegende Band fasst die ersten Impulse des in der Entwicklung begriffenen Symposiums zusammen und bietet Anknüpfungspunkte für eine interdisziplinäre Betrachtung der Didaktiken ästhetischer und musikalischer Bildung.The conference report offers an insight into lectures, group improvisations and performances from the 'DaZwischen 2023' labour conference. This event was created as an initiative for an interdisciplinary music education encounter between teachers and students from various institutions. In the context of conveying the aesthetic - the aesthetic experience and the intention of staging aesthetic experience - indeterminable, contradictory and ambivalent states of aesthetic consciousness and experiencing were described and discussed. This volume summarizes the initial impulses of this specific symposium and its stage in development and offers points of departure for an interdisciplinary consideration of the didactics of aesthetic and musical education