Valeurs normales et reproductibilité de la pression nasale de reniflement chez le jeune adulte sain

CAEN-BU Médecine pharmacie (141182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Mouth and Nasal Inspiratory Pressure: Learning Effect and Reproducibility in Healthy Adults

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[Diagnosis of lung cancer. Fluorescence bronchoscopy]

International audienceAutofluorescence endoscopy is used for more than ten years as an help to the diagnosis of bronchial precancerous lesions and early lung cancers. The technique has been extensively evaluated during the past decade including in two recent randomized studies versus conventional endoscopy that have shown an improvement for the localisation and the diagnosis of high grade precancerous lesions from 2 to 5 times. This paper reviews the principal applications and results of the use of autofluorescence endoscopy in high risk individuals, as well as innovative endoscopic approaches using the fluorescence properties of the respiratory tract

[Diagnosis of lung cancer. Fluorescence bronchoscopy]

International audienceAutofluorescence endoscopy is used for more than ten years as an help to the diagnosis of bronchial precancerous lesions and early lung cancers. The technique has been extensively evaluated during the past decade including in two recent randomized studies versus conventional endoscopy that have shown an improvement for the localisation and the diagnosis of high grade precancerous lesions from 2 to 5 times. This paper reviews the principal applications and results of the use of autofluorescence endoscopy in high risk individuals, as well as innovative endoscopic approaches using the fluorescence properties of the respiratory tract

Effets de l'hypoxie et de l'inflammation sur la synthèse de citrulline dans les entérocytes humains

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Noninvasive Ventilation in Obese Subjects After Acute Respiratory Failure

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An in vitro explant model for studies of intestinal amino acid metabolism

International audienceBackground & aimsThe main role of the small intestine to absorb the bulk of dietary nutrients, including proteins and amino acids (AA). Enterocytes have long been considered a major player in amino acid homeostasis, especially the glutamine–citrulline–arginine crossroads. In vivo intestinal epithelium cell lines for studies of nitrogen metabolism have now reached their limitations. To push research forward, an interesting approach could be to use the explant incubation model of intestinal tissue, involving in vitro incubation of duodenal tissue biopsy specimens taken from human subjects.MethodsEight duodenal biopsies were taken during endoscopy from patients without proven intestinal disease. Each biopsy was incubated in complete culture medium for 23 h then weighed, and cell viability was evaluated after 6 and 18 h. We then explored L-citrulline (L-CIT) production (reflecting metabolic activity) and the presence of the main enzymes involved in AA metabolism in the intestine (arginase II, glutaminase I, ornithine aminotransferase, and ornithine carbamoyltransferase).ResultsMean weight of biopsies was 12.36 ± 1.00 mg. Mortality was around 20% after 6 h and 50% after 18 h of incubation. CIT was amply produced by the biopsies, and enzymes implicated in intestinal AA metabolism were expressed in this model.ConclusionsThis in vitro explant model of intestinal tissue emerges as a reliable model for conducting ex vivo investigations on AA metabolism

Home Non-Invasive Ventilation Fails to Improve Quality of Life in the Elderly: Results from a Multicenter Cohort Study

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Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab.

International audienceLymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin. This report describes the case of a 33-yr-old female with an aggressive form of lymphoid granulomatosis treated with an anti-CD20 antibody. Dramatic radiological improvement was seen at the fourth week. However, the patient died at home 1 month after the last rituximab administration from a massive haemoptysis