A Review of Predictive and Prescriptive Offshore Wind Farm Operation and Maintenance

Offshore wind farms are a rapidly developing source of clean, low-carbon energy and as they continue to grow in scale and capacity, so does the requirement for their efficient and optimised operation and maintenance. Historically, approaches to maintenance have been purely reactive. However, there is a movement in offshore wind, and wider industry in general, towards more proactive, condition-based maintenance approaches which rely on operational data-driven decision making. This paper reviews the current efforts in proactive maintenance strategies, both predictive and prescriptive, of which the latter is an evolution of the former. Both use operational data to determine whether a turbine component will fail in order to provide sufficient warning to carry out necessary maintenance. Prescriptive strategies also provide optimised maintenance actions, incorporating predictions into a wider maintenance plan to address predicted failure modes. Beginning with a summary of common techniques used across both strategies, this review moves on to discuss their respective applications in offshore wind operation and maintenance. This review concludes with suggested areas for future work, underlining the need for models which can be simply incorporated by site operators and integrate live data whilst handling uncertainties. A need for further focus on medium-term planning strategies is also highlighted along with consideration of the question of how to quantify the impact of a proactive maintenance strategy

‘Imagine you are a Dog’ : embodied learning in multi-species research

Based upon a multi-species ethnography of companion dog training in the UK, this paper examines the training class as a site of inter-species communication through which dogs and their humans are mutually affected and transformed. We argue that dog training represents an important form of multi-species learning in which participants (human trainer, trainee and canine) shape one another, jointly if asymmetrically, through the performance of particular tasks and challenges. Successful training requires ‘attunement’ to the haptic and sensory experiences of another species and the creation of shared embodied languages through which relationships of trust and reciprocity are formed. Responding to calls for less human-centred methods we examine the possibilities of visual and ethnographic methods for capturing the ‘animal’s point of view’ and explore how deep ethnographic involvement of the researcher’s own body can draw attention to the everyday complexities of embodied inter-species communication. We consider the importance of our own embodied learning in decentring the human in the research process, engendering a corporeal understanding of the multi-sensory nature of inter-species interaction and transforming ourselves in the process. Through the use of ethnographic vignettes, photos and video stills we highlight the importance of body language, sound, touch, smell and training atmospheres in the creation of shared knowledges. In doing so we explore the possibilities of such methods for evoking the affective dimensions of human-canine interactions and attending to the complex and multiple actors and sensibilities which comprise multi-species training relationships

Fulfilling your dog's potential: changing dimensions of power in dog training cultures

This article explores the workings of power in dog training cultures through an analysis of UK dog training manuals from the mid-19th century to the present. We focus on gundog and companion dog training cultures, investigating the dog-human relations they assume, the changing conceptions of human-animal relations they represent, and the inequalities and relations of power in which they are embedded. Rather than thinking about changing training practices in terms of a shift from dominance to positive training, or from instrumental to affective relations, we argue that training cultures reveal how inter-species inequalities are conceptualised and reproduced in a range of historical periods and cultural spaces. We suggest that dog training cultures can be distinguished by contrasting understandings of dogs as: (1) rational, thinking beings, (2) instinctive creatures, and (3) autonomous active agents as well as by the inequalities of gender, class, race and species structuring the spaces in which they are embedded. Furthermore, the modalities of power which characterise dog training cultures favour different groups of human actors rather than dogs, even in training cultures which are based on partnership and are ‘dog centred’. Our analysis shows how inter-species relations are lived and thought through the cultural practices of dog training

Application of a new multi-locus variable number tandem repeat analysis (MLVA) scheme for the seasonal investigation of Cryptosporidium parvum cases in Wales and the northwest of England, spring 2022

The protozoan Cryptosporidium parvum is an important cause of gastroenteritis in humans and livestock, and cryptosporidiosis outbreaks are common. However, a multi-locus genotyping scheme is not widely adopted. We describe the further development and application of a seven-locus multi-locus variable number of tandem repeats analysis (MLVA) scheme. From 28th March to 31st July 2022, confirmed C. parvum stools (n = 213) from cryptosporidiosis patients (cases) in Wales (n = 95) and the north west of England (n = 118) were tested by MLVA. Typability (defined as alleles identified at all seven loci in a sample) was 81.2% and discriminatory power estimated by Hunter Gaston Discriminatory Index was 0.99. A MLVA profile was constructed from the alleles, expressed in chromosomal order. Profiles were defined as simple (single allele at each locus) or mixed (more than one allele at any locus). A total of 161 MLVA profiles were identified; 13 were mixed, an additional 38 simple profiles contained null records, and 110 were complete simple profiles. A minimum spanning tree was constructed of simple MLVA profiles and those identical at all seven loci defined genetic clusters of cases (here, null records were considered as an allele); 77 cases formed 25 clusters, ranging from two to nine (mode = two) cases. The largest cluster, following epidemiological investigation, signalled a newly-identified outbreak. Two other cases with mixed profiles that contained the outbreak alleles were included in the outbreak investigation. In another epidemiologically-identified outbreak of six initial cases, MLVA detected two additional cases. In a third, small outbreak of three cases, identical MLVA profiles strengthened the microbiological evidence. Review of the performance characteristics of the individual loci and of the seven-locus scheme suggested that two loci might be candidates for review, but a larger dataset over a wider geographical area and longer timeframe will help inform decision-making about the scheme by user laboratories and stakeholders (such as public health agencies). This MLVA scheme is straightforward in use, fast and cheap compared to sequence-based methods, identifies mixed infections, provides an important tool for C. parvum surveillance, and can enhance outbreak investigations and public health action

Life, time, and the organism:Temporal registers in the construction of life forms

In this paper, we articulate how time and temporalities are involved in the making of living things. For these purposes, we draw on an instructive episode concerning Norfolk Horn sheep. We attend to historical debates over the nature of the breed, whether it is extinct or not, and whether presently living exemplars are faithful copies of those that came before. We argue that there are features to these debates that are important to understanding contemporary configurations of life, time and the organism, especially as these are articulated within the field of synthetic biology. In particular, we highlight how organisms are configured within different material and semiotic assemblages that are always structured temporally. While we identify three distinct structures, namely the historical, phyletic and molecular registers, we do not regard the list as exhaustive. We also highlight how these structures are related to the care and value invested in the organisms at issue. Finally, because we are interested ultimately in ways of producing time, our subject matter requires us to think about historiographical practice reflexively. This draws us into dialogue with other scholars interested in time, not just historians, but also philosophers and sociologists, and into conversations with them about time as always multiple and never an inert background

National surveillance data analysis of COVID-19 vaccine uptake in England by women of reproductive age

Women of reproductive age are a group of particular concern with regards to vaccine uptake, related to their unique considerations of menstruation, fertility, and pregnancy. To obtain vaccine uptake data specific to this group, we obtained vaccine surveillance data from the Office for National Statistics, linked with COVID-19 vaccination status from the National Immunisation Management Service, England, from 8 Dec 2020 to 15 Feb 2021; data from 13,128,525 such women at population-level, were clustered by age (18–29, 30–39, and 40–49 years), self-defined ethnicity (19 UK government categories), and index of multiple deprivation (IMD, geographically-defined IMD quintiles). Here we show that among women of reproductive age, older age, White ethnicity and being in the least-deprived index of multiple deprivation are each independently associated with higher vaccine uptake, for first and second doses; however, ethnicity exerts the strongest influence (and IMD the weakest). These findings should inform future vaccination public messaging and policy

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Summary Background Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder. Methods To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations. Findings We identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07–1·15, p=1·84 × 10−9) and the previously identified chromosome 8 locus (near CHRNA2 and EPHX2, lead SNP rs4732724; OR 0·89, 95% CI 0·86–0·93, p=6·46 × 10−9). Cannabis use disorder and cannabis use were genetically correlated (rg 0·50, p=1·50 × 10−21), but they showed significantly different genetic correlations with 12 of the 22 traits we tested, suggesting at least partially different genetic underpinnings of cannabis use and cannabis use disorder. Cannabis use disorder was positively genetically correlated with other psychopathology, including ADHD, major depression, and schizophrenia. Interpretation These findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder. Funding National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.Peer reviewe