The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy

This project was funded by NHS Grampian R&D project number RG05/019Peer reviewedPostprin

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence.

Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents. However, far less is known about the role for hypocretin transmission in regulating ongoing cocaine-taking behavior. Here, we investigated the effects of the selective Hcrt-R1 antagonist SB-334867 on cocaine intake, as measured by intravenous (IV) cocaine self-administration in rats. The stimulatory effects of cocaine on brain reward systems contribute to the establishment and maintenance of cocaine-taking behaviors. Therefore, we also assessed the effects of SB-334867 on the reward-enhancing properties of cocaine, as measured by cocaine-induced lowering of intracranial self-stimulation (ICSS) thresholds. Finally, to definitively establish a role for Hcrt-R1 in regulating cocaine intake, we assessed IV cocaine self-administration in Hcrt-R1 knockout mice. We found that SB-334867 (1-4 mg/kg) dose-dependently decreased cocaine (0.5 mg/kg/infusion) self-administration in rats but did not alter responding for food rewards under the same schedule of reinforcement. This suggests that SB-334867 decreased cocaine reinforcement without negatively impacting operant performance. SB-334867 (1-4 mg/kg) also dose-dependently attenuated the stimulatory effects of cocaine (10 mg/kg) on brain reward systems, as measured by reversal of cocaine-induced lowering of ICSS thresholds in rats. Finally, we found that Hcrt-R1 knockout mice self-administered far less cocaine than wildtype mice across the entire dose-response function. These data demonstrate that Hcrt-R1 play an important role in regulating the reinforcing and reward-enhancing properties of cocaine and suggest that hypocretin transmission is likely essential for establishing and maintaining the cocaine habit in human addicts

Participant views on involvement in a trial of social recovery cognitive behaviour therapy

Background The PRODIGY trial (Prevention of long term social disability amongst young people with emerging psychological difficulties, ISRCTN47998710) is a pilot trial of social recovery cognitive behaviour therapy (SRCBT). Aims The PRODIGY qualitative substudy aimed to (a) explore individual experiences of participating in the pilot randomised, controlled trial (recruitment, randomisation, assessment) andinitial views of therapy, and (b) to explore perceived benefits of taking part in research v. ethical concerns and potential risks. Method Qualitative investigation using semi-structured interviews with thematic analysis. Results Analysis revealed participant experiences around the key themes of acceptability, disclosure, practicalities, altruism and engagement. Conclusions Participants in both trial arms perceived themselves as gaining benefits from being involved in the study, above and beyond the intervention. This has implications for the design of future research and services for this client group, highlighting the importance of being flexible and an individualised approach as key engagement tools

Breaking ground in Canaan: African-American community in Lawrence, 1870-1920

This article was published in the Spring 2014 issue of the Journal of Undergraduate Researc

Approach to universal self-similar attractor for the levelling of thin liquid films

We compare the capillary levelling of a random surface perturbation on a thin polystyrene film with a theoretical study on the two-dimensional capillary-driven thin film equation. Using atomic force microscopy, we follow the time evolution of samples prepared with different initial perturbations of the free surface. In particular, we show that the surface profiles present long term self-similarity, and furthermore, that they converge to a universal self-similar attractor that only depends on the volume of the perturbation, consistent with the theory. Finally, we look at the convergence time for the different samples and find very good agreement with the analytical predictions.Comment: 7 pages, 5 figure