Effect of nose bluntness and afterbody shape on aerodynamic characteristics of a monoplanar missile concept with bodies of circular and elliptical cross sections at a Mach number of 2.50

The tests were performed at a Mach number of 2.50 and at angles of attack from about -4 deg to 32 deg. The results indicate that increasing nose bluntness increases zero lift drag and decreases both the maximum lift-drag ratio and the level of directional stability. The center of pressure generally moves forward with increasing nose size; however, small nose radii on the modified elliptical configurations move the center of pressure rearward. The circular bodied configurations exhibit the greatest longitudinal stability and the least directional stability. Concepts with the variable geometry afterbody contour display the most directional stability and the greatest zero lift drag

Stability and control characteristics at Mach numbers from 0.20 to 4.63 of a cruciform air-to-air missile with triangular canard controls and a trapezoidal wing

Investigations have been conducted in the Langley 8-foot transonic pressure tunnel and the Langley Unitary Plan wind tunnel at Mach numbers from 0.20 to 4.63 to determine the stability and control characteristics of a cruciform air-to-air missile with triangular canard controls and a trapezoidal wing. The results indicate that canards are effective in producing pitching moment throughout most of the test angle-of-attack and Mach number range and that the variations of pitching moment with lift for trim conditions are relatively linear. There is a decrease in canard effectiveness with an increase in angle of attack up to about Mach 2.50 as evidenced by the beginning of coalescence of the pitching-moment curves. At a Mach number above 2.50, there is an increase in effectiveness at moderate to high angles of attack. Simulated launch straps have little effect on the lift and pitch characteristics but do cause an increase in drag, and this increase in drag induces a rolling moment at a zero roll attitude where the straps cause an asymmetric geometric shape. The canards are not suitable devices for roll control and, at some Mach numbers and roll attitudes, are not effective in producing pure yawing moments

Geothermal studies - Yellowstone National Park /test site 11/, Wyoming

Summary report of diamond drilling in thermal areas of Yellowstone National Park, and method for determining heat flow in thermal area

Bi-defects of Nematic Surfactant Bilayers

We consider the effects of the coupling between the orientational order of the two monolayers in flat nematic bilayers. We show that the presence of a topological defect on one bilayer generates a nontrivial orientational texture on both monolayers. Therefore, one cannot consider isolated defects on one monolayer, but rather associated pairs of defects on either monolayer, which we call bi-defects. Bi-defects generally produce walls, such that the textures of the two monolayers are identical outside the walls, and different in their interior. We suggest some experimental conditions in which these structures could be observed.Comment: RevTeX, 4 pages, 3 figure

Epinephrine and clonidine do not improve intrathecal sufentanil analgesia after total hip replacement†

Background. We compared analgesia after intrathecal sufentanil alone, sufentanil with epinephrine 200µg and sufentanil with clonidine 30 µg in patients after total hip replacement, the endpoints being onset and duration of action. Methods. We performed a randomized double‐blind study of 45 patients for elective total hip arthroplasty using continuous spinal anaesthesia. As soon as a pain score higher than 3 on a 10 cm visual analogue scale was reported, sufentanil 7.5 µg alone, sufentanil 7.5 µg + epinephrine 200 µg or sufentanil 7.5 µg + clonidine 30 µg in 2 ml normal saline was given intrathecally. Pain scores, rescue analgesia (diclofenac and morphine) and adverse effects (respiratory depression, postoperative nausea and vomiting, itching) were observed for 24h after surgery. Results. Time to a pain score of 3 [281 (36) vs 288 (23) vs 305 (30) min] were similar in all three groups. Adverse effects and analgesic requirements during the first 24h were also similar. Conclusion. After total hip replacement, all three analgesic regimens gave good analgesia with comparable onset and duration of action, and minor adverse effects. Br J Anaesth 2002; 89: 562-

Clinical ethics consultation in Europe: A comparative and ethical review of the role of patients

Clinical ethics has developed significantly in Europe over the past 15 years and remains an evolving process. While sharing our experiences in different European settings, we were surprised to discover marked differences in our practice, especially regarding the position and role of patients. In this paper, we describe these differences, such as patient access to and participation or representation in ethics consults. We propose reasons to explain these differences, hypothesizing that they relate to the historic and sociocultural context of implementation of clinical ethics consultation services (Cecs), as well as the initial aims for which each structure was established. Then, we analyse those differences with common ethical arguments arising in patient involvement. We conclude that there is no unique model of best practice for patient involvement in clinical ethics, as far as Cecs reflect on how to deal with the challenging ethical issues raised by patient role and position.This article was written by Dr Ainsley Newson during the time of her employment with the University of Bristol, UK (2006-2012). Self-archived in the Sydney eScholarship Repository with permission of Bristol University, Sept 2014

Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control region

The human serine protease inhibitor (serpin) gene cluster at 14q32.1 is a useful model system to study cell-type-specific gene expression and chromatin structure. Activation of the serpin locus can be induced in vitro by transferring human chromosome 14 from non-expressing to expressing cells. Serpin gene activation in expressing cells is correlated with locus-wide alterations in chromatin structure, including the de novo formation of 17 expression-associated DNase I-hypersensitive sites (DHSs). In this study, we investigated histone acetylation throughout the proximal serpin subcluster. We report that gene activation is correlated with high levels of histone H3 and H4 acetylation at serpin gene promoters and other regulatory regions. However, the locus is not uniformly hyperacetylated, as there are regions of hypoacetylation between genes. Furthermore, genetic tests indicate that locus-wide controls regulate both gene expression and chromatin structure. For example, deletion of a previously identified serpin locus control region (LCR) upstream of the proximal subcluster reduces both gene expression and histone acetylation throughout the ∼130 kb region. A similar down regulation phenotype is displayed by transactivator-deficient cell variants, but this phenotype can be rescued by transfecting the cells with expression cassettes encoding hepatocyte nuclear factor-1α (HNF-1α) or HNF-4. Taken together, these results suggest that histone acetylation depends on interactions between the HNF-1α/HNF-4 signaling cascade and the serpin LCR

Rickettsia mongolotimonae: a rare pathogen in France.

We report a second case of laboratory-confirmed infection caused by Rickettsia mongolotimonae in Marseille, France. This rickettsiosis may represent a new clinical entity; moreover, its geographic distribution may be broader than previously documented. This pathogen should be systematically considered in the differential diagnosis of atypical rickettsioses, especially rashless fevers with lymphangitis and lymphadenopathy, in southern France and perhaps elsewhere

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

Tyrosine aminotransferase (TAT) gene expression is liver specific and inducible by glucocorticoids and via the cAMP signaling pathway. In fibroblasts and other nonliver cells the gene is subject to negative control by the trans-dominant tissue-specific extinguisher locus Tse-1. We identified a hepatocyte-specific enhancer that is repressed by Tse-1. Two distinct sequence motifs are absolutely essential for function of this enhancer: a cAMP response element (CRE), which is the target for repression by Tse-1, and a hepatocyte-specific element. The specificity of the enhancer is generated by the combination of these two essential elements, which are fully interdependent. In vivo footprinting indicates that Tse-1 acts by affecting protein binding at the CRE. A direct antagonism between Tse-1 and the cAMP signaling pathway suggests that Tse-1 plays a role in control of developmental activation of the TAT gene

Universality of Velocity Gradients in Forced Burgers Turbulence

It is demonstrated that Burgers turbulence subject to large-scale white-noise-in-time random forcing has a universal power-law tail with exponent -7/2 in the probability density function of negative velocity gradients, as predicted by E, Khanin, Mazel and Sinai (1997, Phys. Rev. Lett. 78, 1904). A particle and shock tracking numerical method gives about five decades of scaling. Using a Lagrangian approach, the -7/2 law is related to the shape of the unstable manifold associated to the global minimizer.Comment: 4 pages, 2 figures, RevTex4, published versio