Moraxella lacunata subacute osteomyelitis in a child

Moraxella lacunata is a rare coccobacillus associated with eye and upper respiratory tract infections. It may also have an affinity for bone and joint tissue. We report on 1 case of subacute osteomyelitis of the patella due to M. lacunata that presented as an osteolytic bone lesion in a child

β₁-AR and β₂-AR SNPs and maximal exercise capacity.

<p>Peak VO₂ is shown for β₁-AR codon 49 and 389, β₂-AR codon 16 and 27. Box graphs represent median, upper/lower quartiles and maximum/minimum values. *indicates a statistically significant difference (p <0.05) between SNP and peak VO₂. Figures represent box plot for each genotype combination (homozygous for the major allele, WT/WT, heterozygous WT/minor allele and homozygous for minor allele).</p

Multivariable correlation between peak VO₂, β₁-AR genotype and clinical variables.

<p>ΔHR = Peak heart rate—resting heart rate; BP = Blood Pressure; eGFR = estimated glomerular filtration rate.</p

Mean circumferential strain at basal, mid-ventricular and apical slices of the left ventricle comparing β₁-AR Ser49Ser and β₁-Gly49 carriers along the cardiac cycle.

<p>The strain values were obtained using HARP analysis on tagged images acquired with a SF bSSFP CSPAMM tagging technique. All measurements were adapted to the systole duration of each exam. No statistically significant difference could be found between the two groups.</p

ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis

PURPOSE: Intravenous maintenance fluid therapy (IV-MFT) prescribing in acute and critically ill children is very variable among pediatric health care professionals. In order to provide up to date IV-MFT guidelines, the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) undertook a systematic review to answer the following five main questions about IV-MFT: (i) the indications for use (ii) the role of isotonic fluid (iii) the role of balanced solutions (iv) IV fluid composition (calcium, magnesium, potassium, glucose and micronutrients) and v) and the optimal amount of fluid. METHODS: A multidisciplinary expert group within ESPNIC conducted this systematic review using the Scottish Intercollegiate Guidelines Network (SIGN) grading method. Five databases were searched for studies that answered these questions, in acute and critically children (from 37 weeks gestational age to 18 years), published until November 2020. The quality of evidence and risk of bias were assessed, and meta-analyses were undertaken when appropriate. A series of recommendations was derived and voted on by the expert group to achieve consensus through two voting rounds. RESULTS: 56 papers met the inclusion criteria, and 16 recommendations were produced. Outcome reporting was inconsistent among studies. Recommendations generated were based on a heterogeneous level of evidence, but consensus within the expert group was high. "Strong consensus" was reached for 11/16 (69%) and "consensus" for 5/16 (31%) of the recommendations. CONCLUSIONS: Key recommendations are to use isotonic balanced solutions providing glucose to restrict IV-MFT infusion volumes in most hospitalized children and to regularly monitor plasma electrolyte levels, serum glucose and fluid balance

Correction to:Intravenous maintenance fluid therapy practice in the pediatric acute and critical care settings: a European and Middle Eastern survey (European Journal of Pediatrics, (2022), 181, 8, (3163-3172), 10.1007/s00431-022-04467-y)

In the original published version of the above article, the following names under "the ESPNICIVMFT group" were presented incorrectly and are now corrected as shown below: Luregn J Schlapbach Fabrizio Chiusolo and is affiliated to "Pediatric Intensive Care, Bambino Gesù Children’s Hospital, Rome, Italy" Stavroula Ilia The original article has been corrected.</p

ESPNIC clinical practice guidelines ::intravenous maintenance fluid therapy in acute and critically ill children : a systematic review and meta-analysis

Purpose: Intravenous maintenance fluid therapy (IV-MFT) prescribing in acute and critically ill children is very variable among pediatric health care professionals. In order to provide up to date IV-MFT guidelines, the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) undertook a systematic review to answer the following five main questions about IV-MFT: (i) the indications for use (ii) the role of isotonic fluid (iii) the role of balanced solutions (iv) IV fluid composition (calcium, magnesium, potassium, glucose and micronutrients) and v) and the optimal amount of fluid. Methods: A multidisciplinary expert group within ESPNIC conducted this systematic review using the Scottish Intercollegiate Guidelines Network (SIGN) grading method. Five databases were searched for studies that answered these questions, in acute and critically children (from 37 weeks gestational age to 18 years), published until November 2020. The quality of evidence and risk of bias were assessed, and meta-analyses were undertaken when appropriate. A series of recommendations was derived and voted on by the expert group to achieve consensus through two voting rounds. Results: 56 papers met the inclusion criteria, and 16 recommendations were produced. Outcome reporting was inconsistent among studies. Recommendations generated were based on a heterogeneous level of evidence, but consensus within the expert group was high. “Strong consensus” was reached for 11/16 (69%) and “consensus” for 5/16 (31%) of the recommendations