Reliability Testing of the PABS (Pedestrian and Bicycling Survey) Method

The Pedestrian and Bicycling Survey (PABS) is a questionnaire designed to be economical and straightforward to administer so that it can be used by local governments interested in measuring the amount and purposes of walking and cycling in their communities. In addition, it captures key sociodemographic characteristics of those participating in these activities. Methods: In 2009 and 2010 results from the 4-page mail-out/mail-back PABS were tested for reliability across 2 administrations (test-retest reliability). Two versions--early and refined--were tested separately with 2 independent groups of university students from 4 universities (N = 100 in group 1; N = 87 in group 2). Administrations were 7 to 9 days apart. Results: Almost all survey questions achieved adequate to excellent reliability. Conclusions: Transportation surveys have not typically been tested for reliability making the PABS questionnaire an important new option for improving information collection about travel behavior, particularly walking and cycling

A Mixed Methods Approach to Identifying Administration Issues Pertinent in Interscholastic Sports

The purpose of this study was to investigate three propositions: a) What are the administration issues most pertinent to interscholastic sport today, as well as the next five years?, b) How important are those administration issues to athletic administrators?, and c) What are the potential implications of those pertinent administration issues to practicing athletic administrators? The literature provides a general overview of relevant issues surrounding interscholastic athletics. However, the importance and implications of relevant issues to practicing high school athletic administrators are difficult to discern. To answer the first proposition, the Minnesota State High School League (MSHSL) provided 10 contemporary administration issues that were most pertinent to interscholastic sport today, as well as the next five years. To answer the second proposition, a Likert-Scale was created so that practicing athletic administrators could rate each issue on a scale of 5 = extremely important to 1 = very little importance. A national study was conducted with athletic directors from the National Interscholastic Athletic Administrators Association (N = 170) annual conference. A one-tailed ANOVA was executed to determine significant differences among the 10 administration issues identified by the MSHSL. Four issues were found to be significant; Athletic Facilities, Athletic Training, Health Issues and Travel Teams. A Games-Howell post hoc was executed to determine significant differences across geographical regions of the United States. For the third proposition, semi-structured interviews were completed to provide insight on the implications for practicing athletic administrators. The results offer insight from which further investigations could be conducted to continue building on policies that influence interscholastic athletic administrators’ day-to-day accountability when overseeing their athletic programs

Lexical and Discourse Analysis of Online Chat Dialog

One of the ultimate goals of natural language processing (NLP) systems is understanding the meaning of what is being transmitted, irrespective of the medium (e.g., written versus spoken) or the form (e.g., static documents versus dynamic dialogues). Although much work has been done in traditional language domains such as speech and static written text, little has yet been done in the newer communication domains enabled by the Internet, e.g., online chat and instant messaging. This is in part due to the fact that there are no annotated chat corpora available to the broader research community. The purpose of this research is to build a chat corpus, tagged with lexical (token part-of-speech labels), syntactic (post parse tree), and discourse (post classification) information. Such a corpus can then be used to develop more complex, statistical-based NLP applications that perform tasks such as author profiling, entity identification, and social network analysis

Localization and Characterization of Fatigue Cracks Around Fastener Holes Using Spherically Focused Ultrasonic Probes

Results are presented from laboratory experiments and simulations designed to determine the ability to localize and characterize fatigue cracks around fastener holes using spherically fo-cused ultrasonic (UT) probes for shear-wave inspections. In designing and evaluating inspection protocols, the number of cases that can be studied through laboratory experiments is severely limited by cost and time constraints. Simulations therefore stand to play a significant role in the design and optimization of inspection strategies for those conditions that can be accurately mod-eled. Moving from benchmark studies for relatively simple geometries toward more realistic conditions creates significant challenges. For shear-wave inspections of fastener holes these challenges include the complex energy field in the thin plates, reflections off the borehole, the complexity of making measurements in the near-field, material anisotropy, cracks as small as 1mm square, and a sealant layer between aluminum sheets. To achieve comparable modeling and simulation data requires a very accurate experimental setup that allows the probe angle, probe height and scan path to be precisely set. For the modeling, care must be taken to match the applied gain and gates used during acquisition of the experimental data. Initial results presented include sensitivity studies to determine how probe variables (frequency, focal depth, diameter), crack variables (size, shape, location, angle with respect to the probe), and the experimental setup affect results. Simulated and experimental C-scan images for 5 and 10 MHz probes are shown in Figure 1 for a fatigue crack that intersects the back wall. This work is supported by the U.S. Air Force Research Laboratory (AFRL) through Research Initiatives for Materials State Sensing (RIMSS) contract with Universal Technologies Corp., Contract No: FA8650-10-D-5210

Model Benchmarking and Reference Signals for Angled-beam Shear Wave Ultrasonic NDE Inspections

NDE modeling and simulation are important tools to support the development and validation of enhanced localization and characterization techniques. Previously, important achievements were made by the USAF to address crack detection in aircraft structures using angled-beam shear wave inspection techniques. However, new work on model benchmarking is needed to move beyond detection and achieve reliable crack characterization. To achieve this goal, simulated studies are needed to verify that models can accurately represent all of the key variables with the inspection of multilayer structures with fastener sites and varying crack conditions. Often with model benchmark studies, the accuracy of the model is evaluated based on the change in response relative to a selected reference signal. During recent simulated and experimental studies, some challenges were discovered concerning the creation and/or selection of a reference signal in a plate with a vertical hole and crack. The focus of this paper is on key findings concerning model benchmarking using CIVA-UT for angled-beam shear wave inspections. The use of a side drilled hole (SDH) in a plate was found to be somewhat problematic as a reference signal for angled beam shear wave inspection. Previously, only a limited number of studies have looked at model benchmarking for angled beam shear wave inspections. Systematic studies were performed with varying SDH depth and size, and varying the ultrasonic probe frequency, focal depth, and probe height. Care must be taken in understanding the precise beam properties with these experiments. One issue is that there is some increased error with the simulation of angled shear wave beams, especially in the near-field. Even more significant, asymmetry in real probes and the inherent sensitivity of signals in the near-field to subtle test conditions were found to provide a greater challenge with achieving model agreement. Through these studies, conditions of good and poor agreement were observed. For some inspection conditions, the skip signal off of the far wall from the side drilled hole can provide a better reference than the direct reflected signal. All in all, these seemingly mundane studies were found to be important with providing guidance on reference signal selection for model benchmarking work on the inspection of fastener sites with cracks

Forty years later: distribution of the introduced Heath Snail, Xerolenta obvia, in Ontario, Canada (Mollusca: Gastropoda: Hygromiidae)

Xerolenta obvia is a Central European land snail that is introduced to Ontario, Canada, where it was first recorded in the literature in 1975 from a single population at Bethany (City of Kawartha Lakes). Over the four decades since that publication, additional records have been found clustered near Bethany, within the City of Kawartha Lakes, and in neighbouring Peterborough County and the Regional Municipality of Durham. Two distant sites are also now known, one in rural Ottawa (southeastern Ontario), and one at Windsor, Essex County (southwestern Ontario)

The chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data platform

Background: Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations still exist in our understanding of CD. Harnessing individual participant data (IPD) from studies could support more in-depth analyses to address the many outstanding research questions. This systematic review aims to describe the characteristics and treatment practices of clinical studies in CD and assess the breadth and availability of research data for the potential establishment of a data-sharing platform. Methodology/Principal findings This review includes prospective CD clinical studies published after 1997 with patients receiving a trypanocidal treatment. The following electronic databases and clinical trial registry platforms were searched: Cochrane Library, PubMed, Embase, LILACS, Scielo, Clintrials. gov, and WHO ICTRP. Of the 11,966 unique citations screened, 109 (0.9%) studies (31 observational and 78 interventional) representing 23,116 patients were included. Diagnosis for patient enrolment required 1 positive test result in 5 (4.6%) studies (2 used molecular method, 1 used molecular and serology, 2 used serology and parasitological methods), 2 in 60 (55.0%), 3 in 14 (12.8%) and 4 or more in 4 (3.7%) studies. A description of treatment regimen was available for 19,199 (83.1%) patients, of whom 14,605 (76.1%) received an active treatment and 4,594 (23.9%) were assigned to a placebo/no-treatment. Of the 14,605 patients who received an active treatment, benznidazole was administered in 12,467 (85.4%), nifurtimox in 825 (5.6%), itraconazole in 284 (1.9%), allopurinol in 251(1.7%) and other drugs in 286 (1.9%). Assessment of efficacy varied largely and was based primarily on biological outcome; parasitological efficacy relied on serology in 67/85 (78.8%) studies, molecular methods in 52/85 (61.2%), parasitological in 34/85 (40.0%), microscopy in 3/85 (3.5%) and immunohistochemistry in 1/85 (1.2%). The median time at which parasitological assessment was carried out was 79 days [interquartile range (IQR): 30–180] for the first assessment, 180 days [IQR: 60–500] for second, and 270 days [IQR: 18–545] for the third assessment. Conclusions/Significance This review demonstrates the heterogeneity of clinical practice in CD treatment and in the conduct of clinical studies. The sheer volume of potential IPD identified demonstrates the potential for development of an IPD platform for CD and that such efforts would enable indepth analyses to optimise the limited pharmacopoeia of CD and inform prospective data collection.Fil: Maguire, Brittany J.. University of Oxford; Reino UnidoFil: Dahal, Prabin. University of Oxford; Reino UnidoFil: Rashan, Sumayyah. University of Oxford; Reino UnidoFil: Ngu, Roland. University of Oxford; Reino UnidoFil: Boon, Anca. University of Oxford; Reino UnidoFil: Forsyth, Colin. No especifíca;Fil: Strub Wourgraft, Nathalie. No especifíca;Fil: Chatelain, Eric. No especifíca;Fil: Barreira, Fabiana. No especifíca;Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Guerin, Philippe J.. University of Oxford; Reino Unid

The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations

This paper reviews current knowledge on the role of the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, 20:4n-6), in maternal and term infant nutrition as well as infant development. Consensus recommendations and practice guidelines for health-care providers supported by the World Association of Perinatal Medicine, the Early Nutrition Academy, and the Child Health Foundation are provided. The fetus and neonate should receive LC-PUFA in amounts sufficient to support optimal visual and cognitive development. Moreover, the consumption of oils rich in n-3 LC-PUFA during pregnancy reduces the risk for early premature birth. Pregnant and lactating women should aim to achieve an average daily intake of at least 200mg DHA. For healthy term infants, we recommend and fully endorse breastfeeding, which supplies preformed LC-PUFA, as the preferred method of feeding. When breastfeeding is not possible, we recommend use of an infant formula providing DHA at levels between 0.2 and 0.5 weight percent of total fat, and with the minimum amount of AA equivalent to the contents of DHA. Dietary LC-PUFA supply should continue after the first six months of life, but currently there is not sufficient information for quantitative recommendation

Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas

<p>Abstract</p> <p>Background</p> <p>Matrix metalloproteinases (MMPs) are enzymes that promote tumor invasion and angiogenesis by enzymatically remodeling the extracellular matrix. MMP-2 and MMP-9 are the most abundant forms of MMPs in malignant gliomas, while a 130 kDa MMP is thought to be MMP-9 complexed to other proteinases. This study determined whether doxycycline can block MMP activity <it>in vitro</it>. We also measured MMP-2 and MMP-9 levels in cerebrospinal fluid (CSF) from patients with recurrent malignant gliomas.</p> <p>Methods</p> <p>To determine whether doxycycline can block MMP activity, we measured the extent of doxycyline-mediated MMP-2 and MMP-9 inhibition <it>in vitro </it>using epidermal growth factor receptor (EGFR) transfected U251 glioma cell lines. MMP activity was measured using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) zymography. In addition, patients underwent lumbar puncture for CSF sampling at baseline, after 6 weeks (1 cycle), and after 12 weeks (2 cycles), while being treated with a novel chemotherapy regimen of irinotecan, thalidomide, and doxycycline designed to block growth/proliferation, angiogenesis, and invasion. Irinotecan was given at 125 mg/m²/week for 4 weeks in 6-week cycles, together with continuous doxycycline at 100 mg twice daily on Day 1 and 50 mg twice daily thereafter. Daily thalidomide dose in our cohort was 400 mg. Tumor progression was monitored by magnetic resonance imaging (MRI).</p> <p>Results</p> <p>Doxycyline <it>in vitro </it>completely abolished MMP-9 activity at 500 μg/ml while there was only 30 to 50% inhibition of MMP-2 activity. Four patients respectively completed 4, 3, 1, and 2 cycles of irinotecan, thalidomide, and doxycycline. Patient enrollment was terminated after one patient developed radiologically defined pulmonary embolism, and another had probable pulmonary embolism. Although CSF MMP-2 and 130 kDa MMP levels were stable, MMP-9 level progressively increased during treatment despite stable MRI.</p> <p>Conclusion</p> <p>Doxycycline can block MMP-2 and MMP-9 activities from glioma cells <it>in vitro</it>. Increased CSF MMP-9 activity could be a biomarker of disease activity in patients with malignant gliomas, before any changes are detectable on MRI.</p