90 research outputs found
Evaluation of Machine Learning Methods to Predict Coronary Artery Disease Using Metabolomic Data
Metabolomic data can potentially enable accurate, non-invasive and low-cost prediction of coronary artery disease. Regression-based analytical approaches however might fail to fully account for interactions between metabolites, rely on a priori selected input features and thus might suffer from poorer accuracy. Supervised machine learning methods can potentially be used in order to fully exploit the dimensionality and richness of the data. In this paper, we systematically implement and evaluate a set of supervised learning methods (L1 regression, random forest classifier) and compare them to traditional regression-based approaches for disease prediction using metabolomic data
Electric properties of the Beryllium-11 system in Halo EFT
We compute E1 transitions and electric radii in the Beryllium-11 nucleus
using an effective field theory that exploits the separation of scales in this
halo system. We fix the leading-order parameters of the EFT from measured data
on the 1/2+ and 1/2- levels in Be-11 and the B(E1) strength for the transition
between them. We then obtain predictions for the B(E1) strength for Coulomb
dissociation of the Be-11 nucleus to the continuum. We also compute the charge
radii of the 1/2+ and 1/2- states. Agreement with experiment within the
expected accuracy of a leading-order computation in this EFT is obtained. We
also discuss how next-to-leading-order (NLO) corrections involving both s-wave
and p-wave neutron-Be-10 interactions affect our results, and display the NLO
predictions for quantities which are free of additional short-distance
operators at this order. Information on neutron-Be-10 scattering in the
relevant channels is inferred.Comment: 27 pages, 8 figures, final versio
Recent advances in the theory of nuclear forces
After a brief historical review, we present recent progress in our
understanding of nuclear forces in terms of chiral effective field theory.Comment: 6 pages, 2 figures; talk at International Symposium on Correlations
Dynamics in Nuclei, University of Tokyo, Japan, 31 January-4 February, 200
Bayesian optimization in ab initio nuclear physics
Theoretical models of the strong nuclear interaction contain unknown coupling constants (parameters) that must be determined using a pool of calibration data. In cases where the models are complex, leading to time consuming calculations, it is particularly challenging to systematically search the corresponding parameter domain for the best fit to the data. In this paper, we explore the prospect of applying Bayesian optimization to constrain the coupling constants in chiral effective field theory descriptions of the nuclear interaction. We find that Bayesian optimization performs rather well with low-dimensional parameter domains and foresee that it can be particularly useful for optimization of a smaller set of coupling constants. A specific example could be the determination of leading three-nucleon forces using data from finite nuclei or three-nucleon scattering experiments
Modern topics in theoretical nuclear physics
Over the past five years there have been profound advances in nuclear physics
based on effective field theory and the renormalization group. In this brief,
we summarize these advances and discuss how they impact our understanding of
nuclear systems and experiments that seek to unravel their unknowns. We discuss
future opportunities and focus on modern topics in low-energy nuclear physics,
with special attention to the strong connections to many-body atomic and
condensed matter physics, as well as to astrophysics. This makes it an exciting
era for nuclear physics.Comment: 8 pages, 1 figure, prepared for the Nuclear Physics Town Hall Meeting
at TRIUMF, Sept. 9-10, 2005, comments welcome, references adde
Lattice Simulations for Light Nuclei: Chiral Effective Field Theory at Leading Order
We discuss lattice simulations of light nuclei at leading order in chiral
effective field theory. Using lattice pion fields and auxiliary fields, we
include the physics of instantaneous one-pion exchange and the leading-order
S-wave contact interactions. We also consider higher-derivative contact
interactions which adjust the S-wave scattering amplitude at higher momenta. By
construction our lattice path integral is positive definite in the limit of
exact Wigner SU(4) symmetry for any even number of nucleons. This SU(4)
positivity and the approximate SU(4) symmetry of the low-energy interactions
play an important role in suppressing sign and phase oscillations in Monte
Carlo simulations. We assess the computational scaling of the lattice algorithm
for light nuclei with up to eight nucleons and analyze in detail calculations
of the deuteron, triton, and helium-4.Comment: 44 pages, 15 figure
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
Background: Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway-predominant and emphysema-predominant COPD may be clinically relevant. The objective was to define clinical features of emphysema-predominant and non-emphysematous COPD patients. Methods: Current and former smokers from the Genetic Epidemiology of COPD Study (COPDGene) had chest computed tomography (CT) scans with quantitative image analysis. Emphysema-predominant COPD was defined by low attenuation area at -950 Hounsfield Units (LAA-950) ≥10%. Non-emphysematous COPD was defined by airflow obstruction with minimal to no emphysema (LAA-950 < 5%). Results: Out of 4197 COPD subjects, 1687 were classified as emphysema-predominant and 1817 as non-emphysematous; 693 had LAA-950 between 5-10% and were not categorized. Subjects with emphysema-predominant COPD were older (65.6 vs 60.6 years, p < 0.0001) with more severe COPD based on airflow obstruction (FEV1 44.5 vs 68.4%, p < 0.0001), greater exercise limitation (6-minute walk distance 1138 vs 1331 ft, p < 0.0001) and reduced quality of life (St. George's Respiratory Questionnaire score 43 vs 31, p < 0.0001). Self-reported diabetes was more frequent in non-emphysematous COPD (OR 2.13, p < 0.001), which was also confirmed using a strict definition of diabetes based on medication use. The association between diabetes and non-emphysematous COPD was replicated in the ECLIPSE study. Conclusions: Non-emphysematous COPD, defined by airflow obstruction with a paucity of emphysema on chest CT scan, is associated with an increased risk of diabetes. COPD patients without emphysema may warrant closer monitoring for diabetes, hypertension, and hyperlipidemia and vice versa
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