Promoting radio astronomy in Ghana through school visits and Astronomy Clubs

The Promoting Radio Astronomy in Ghana through School visits and Astronomy Clubs (PRAGSAC) project was an intervention to promote astronomy education in schools in Ghana. It was initiated by a group of enthusiastic students who were trained in radio astronomy and astrophysics under a Royal Society/Newton Fund UK project termed Development in Africa with Radio Astronomy. The team's aim is to expose school children to astronomy and to increase their interest in the sciences. Approximately 800 school children from seven junior high schools were positively impacted by this project. Astronomy clubs were formed in the selected schools with practical astronomy lessons taught. The kids visited the largest single radio telescope in Africa at Kuntunse in Accra and were amazed about the engineering and the science that it undertakes. For the patrons of the clubs, a teacher training workshop was organised for them, so as to equip them to manage the clubs. The feedback from students and teachers was exceptionally positive, implying that the PRAGSAC project has helped inspire more students to pursue courses and consider careers within the sciences

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the host’s protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly, slow healers had deeper metabolic and coagulation defects at the start of antibiotic therapy. In addition to providing novel insight into Buruli ulcer pathogenesis, our study therefore identifies a unique proteomic signature for this disease

Integrated use of fertilizer micro-dosing and Acacia tumida mulching increases millet yield and water use efficiency in Sahelian semi-arid environment

Limited availability of soil organic amendments and unpredictable rainfall, decrease crop yields drastically in the Sahel. There is, therefore, a need to develop an improved technology for conserving soil moisture and enhancing crop yields in the Sahelian semi-arid environment. A 2-year field experiment was conducted to investigate the mulching effects of Acacia tumida pruning relative to commonly applied organic materials in Niger on millet growth, yields and water use efficiency (WUE) under fertilizer micro-dosing technology. We hypothesized that (1) A. tumida pruning is a suitable mulching alternative for crop residues in the biomass-scarce areas of Niger and (2) combined application of A. tumida mulch and fertilizer micro-dosing increases millet yield and water use efficiency. Two fertilizer micro-dosing options (20 kg DAP ha−1, 60 kg NPK ha−1) and three types of organic mulches (millet straw, A. tumida mulch, and manure) and the relevant control treatments were arranged in factorial experiment organized in a randomized complete block design with four replications. Fertilizer micro-dosing increased millet grain yield on average by 28 %. This millet grain yield increased further by 37 % with combined application of fertilizer micro-dosing and organic mulch. Grain yield increases relative to the un-mulched control were 51 % for manure, 46 % for A. tumida mulch and 36 % for millet mulch. Leaf area index and root length density were also greater under mulched plots. Fertilizer micro-dosing increased WUE of millet on average by 24 %, while the addition of A. tumida pruning, manure and millet increased WUE on average 55, 49 and 25 %, respectively. We conclude that combined application of micro-dosing and organic mulch is an effective fertilization strategy to enhance millet yield and water use efficiency in low-input cropping systems and that A. tumida pruning could serve as an appropriate mulching alternative for further increasing crop yields and water use efficiency in the biomass-scarce and drought prone environment such as the Sahel. However, the economic and social implications and the long-term agronomic effects of this agroforestry tree in Sahelian millet based system have to be explored further

Timing of susceptibility-based antifungal drug administration in patients with Candida bloodstream infection: Correlation with outcomes

10.1093/jac/dkr511Journal of Antimicrobial Chemotherapy673707-714JACH