57 research outputs found
Impact of alcohol use disorder severity on human immunodeficiency virus (HIV) viral suppression and CD4 count in three international cohorts of people with HIV.
Alcohol use has been linked to worse human immunodeficiency virus (HIV) immunologic/virologic outcomes, yet few studies have explored the effects of alcohol use disorder (AUD). This study assessed whether AUD severity is associated with HIV viral suppression and CD4 count in the three cohorts of the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium.
People with HIV (PWH) in Uganda (n = 301), Russia (n = 400), and Boston (n = 251), selected in-part based on their alcohol use, were included in analyses. Logistic and linear regressions were used to assess the cross-sectional associations between AUD severity (number of DSM-5 diagnostic criteria) and (1) HIV viral suppression, and (2) CD4 count (cells/mm <sup>3</sup> ) adjusting for covariates. Analyses were conducted separately by site.
The proportion of females was 51% (Uganda), 34% (Russia), and 33% (Boston); mean age (SD) was 40.7 (9.6), 38.6 (6.3), and 52.1 (10.5), respectively. All participants in Uganda and all but 27% in Russia and 5% in Boston were on antiretroviral therapy. In Uganda, 32% met criteria for AUD, 92% in Russia, and 43% in Boston. The mean (SD) number of AUD criteria was 1.6 (2.4) in Uganda, 5.6 (3.3) in Russia, and 2.4 (3.1) in Boston. Most participants had HIV viral suppression (Uganda 92%, Russia 57%, Boston 87%); median (IQR) CD4 count was 673 (506, 866), 351 (201, 542), and 591 (387, 881), respectively. In adjusted models, there were no associations between AUD severity and HIV viral suppression: adjusted odds ratios (AOR) (95%CI) per 1 additional AUD criterion in Uganda was 1.08 (0.87, 1.33); Russia 0.98 (0.92, 1.04); and Boston 0.95 (0.84, 1.08) or CD4 count: mean difference (95%CI) per 1 additional criterion: 5.78 (-7.47, 19.03), -3.23 (-10.91, 4.44), and -8.18 (-24.72, 8.35), respectively.
In three cohorts of PWH, AUD severity was not associated with HIV viral suppression or CD4 count. PWH with AUD in the current era of antiretroviral therapy can achieve virologic control
Functional determinants for general self-adjoint extensions of Laplace-type operators resulting from the generalized cone
In this article we consider the zeta regularized determinant of Laplace-type
operators on the generalized cone. For {\it arbitrary} self-adjoint extensions
of a matrix of singular ordinary differential operators modelled on the
generalized cone, a closed expression for the determinant is given. The result
involves a determinant of an endomorphism of a finite-dimensional vector space,
the endomorphism encoding the self-adjoint extension chosen. For particular
examples, like the Friedrich's extension, the answer is easily extracted from
the general result. In combination with \cite{BKD}, a closed expression for the
determinant of an arbitrary self-adjoint extension of the full Laplace-type
operator on the generalized cone can be obtained.Comment: 27 pages, 2 figures; to appear in Manuscripta Mathematic
Metastability Driven by Soft Quantum Fluctuation Modes
The semiclassical Euclidean path integral method is applied to compute the
low temperature quantum decay rate for a particle placed in the metastable
minimum of a cubic potential in a {\it finite} time theory. The classical path,
which makes a saddle for the action, is derived in terms of Jacobian elliptic
functions whose periodicity establishes the one-to-one correspondence between
energy of the classical motion and temperature (inverse imaginary time) of the
system. The quantum fluctuation contribution has been computed through the
theory of the functional determinants for periodic boundary conditions. The
decay rate shows a peculiar temperature dependence mainly due to the softening
of the low lying quantum fluctuation eigenvalues. The latter are determined by
solving the Lam\`{e} equation which governs the fluctuation spectrum around the
time dependent classical bounce.Comment: Journal of Low Temperature Physics (2008) Publisher: Springer
Netherland
Structural chemistry of metal coordination complexes at high pressure
The application of pressures of up to about 10 GPa may induce significant geometric, configurational, conformational and packing changes in molecular solids. This review highlights and describes recent advances in high pressure studies of coordination complexes, many of which have been conducted at synchrotrons or other central facilities. The main focus is on the wide range of geometric changes which occur with pressure. In some cases these changes have associated physical effects, and the review describes materials exhibiting negative linear compressibility, spin cross-over phenomena, magnetism and molecular conduction, as well as detailing the exciting possibilities for future developments in this area of research
GEOPROCESSING APPLIED TO RISK ASSESSMENT OF FOREST FIRES IN THE MUNICIPALITY OF BODOQUENA, MATO GROSSO DO SUL
Sobre a analgesia pós-operatória da morfina, cetamina ou da associação em cadelas submetidas à ovariossalpingohisterectomia eletiva
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