In Vitro Fertilized Embryos do not Secrete Detectable HLA-G on Day Two

ABSTRACT Background: Pregnancy is a successful transplantation. The factors evading rejection of the fetus are poorly understood. Recently an interest has grown, in HLA-G molecules as one of these factors. Since these antigens are mainly expressed on the surface of cytotrophoblasts that are in direct contact with maternal tissues, it has been suggested that these molecules may have a role in induction of immune tolerance in mothers. Objective: to find the association of soluble HLA-G (sHLA-G) and the success of pregnancy with intracytoplasmic sperm injection (ICSI) procedure. Methods: In this study, the supernatant of 287 individually cultured embryos corresponding to 96 women under ICSI procedure were assayed for soluble HLA-G1 and G5 by a sandwich ELISA. Results: Clinical pregnancy successfully occurred in 30 of candidates. No differences in clinical parameters (age, infertility duration, stimulation regimen) were observed between pregnant and nonpregnant women under ICSI procedure. None of the embryo supernatants in either group showed any detectable sHLA-G molecules. Conclusion: Our results showed that detectable level of sHLA-G is not produced by day 2 embryos and such a measurement may not provide reliable information for embryo selection and estimation of pregnancy success

Krein Regularization of \lambda\phi^4

We calculate the four-point function in \lambda\phi^4 theory by using Krein regularization and compare our result, which is finite, with the usual result in \lambda\phi^4 theory. The effective coupling constant (\lambda_\mu) is also calculated in this method

Effective Action of λφ3 in Krein Space Quantization

The appearance of divergence creates computational issues in the process of calculating the one-loop effective action of λφ3 in quantum field theory. In this paper, it is demonstrated that using Krein space quantization with Ford’s method of fluctuated metrics, divergence can be removed and that without using any traditional regularization method, it is possible to arrive at a finite solution for the effective action.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Evaluation of foot self-care status and foot screening problems in patients with diabetes in Iran: a national multicenter study

Abstract Background and purpose The lack of timely foot care among individuals with diabetics often lead to ulceration followed by infection and amputation. This study aimed to evaluate the foot self-care status and foot screening practices among patients with type 2 diabetes in various cities across Iran. Methods The cross-sectional descriptive study was performed on patients with type 2 diabetes in 10 main cities of Iran. The information about demographic and lifestyle factors, diabetes history, and diabetic foot self-care (DFSQ) was assessed. Additionally, the neurological and vascular condition of the foot were screened by Inlow’s 60-Second Screen. Results The study included 1094 diabetic patients with, with a majority being female (64.8%) and married (92.5%). The average age of the participants was 57.6 ± 10.21 (mean ± SD), and the mean duration of diabetes was 11.56 ± 7.41 years. Based on Inlow’s 60-Second Screen criteria, 58% of the patients should undergo yearly foot ulcer screening, 47% exhibited peripheral neuropathy, and 37% were found to have inappropriate footwear. Conclusion The high prevalence of peripheral neuropathy observed in approximately half of the participants across different regions of Iran underscores the importance of continuous patient education regarding foot care and appropriate footwear. Furthermore, regular foot ulcer screenings, following the recommended intervals outlined in Inlow’s screening protocol, should be implemented to effectively manage diabetic foot complications