Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE).

AIMS/HYPOTHESIS: Lower birthweight (a marker of fetal undernutrition) is associated with higher risks of type 2 diabetes and cardiovascular disease (CVD) and could explain ethnic differences in these diseases. We examined associations between birthweight and risk markers for diabetes and CVD in UK-resident white European, South Asian and black African-Caribbean children. METHODS: In a cross-sectional study of risk markers for diabetes and CVD in 9- to 10-year-old children of different ethnic origins, birthweight was obtained from health records and/or parental recall. Associations between birthweight and risk markers were estimated using multilevel linear regression to account for clustering in children from the same school. RESULTS: Key data were available for 3,744 (66%) singleton study participants. In analyses adjusted for age, sex and ethnicity, birthweight was inversely associated with serum urate and positively associated with systolic BP. After additional height adjustment, lower birthweight (per 100 g) was associated with higher serum urate (0.52%; 95% CI 0.38, 0.66), fasting serum insulin (0.41%; 95% CI 0.08, 0.74), HbA1c (0.04%; 95% CI 0.00, 0.08), plasma glucose (0.06%; 95% CI 0.02, 0.10) and serum triacylglycerol (0.30%; 95% CI 0.09, 0.51) but not with BP or blood cholesterol. Birthweight was lower among children of South Asian (231 g lower; 95% CI 183, 280) and black African-Caribbean origin (81 g lower; 95% CI 30, 132). However, adjustment for birthweight had no effect on ethnic differences in risk markers. CONCLUSIONS/INTERPRETATION: Birthweight was inversely associated with urate and with insulin and glycaemia after adjustment for current height. Lower birthweight does not appear to explain emerging ethnic difference in risk markers for diabetes

Kondo effect in a one dimensional d-wave superconductor

We derive a solvable resonant-level type model, to describe an impurity spin coupled to zero-energy bound states localized at the edge of a one dimensional d-wave superconductor. This results in a two-channel Kondo effect with a quite unusual low-temperature thermodynamics. For instance, the local impurity susceptibility yields a finite maximum at zero temperature (but no logarithmic-divergence) due to the splitting of the impurity in two Majorana fermions. Moreover, we make comparisons with the Kondo effect occurring in a two dimensional d-wave superconductor.Comment: 9 pages, final version; To be published in Europhysics Letter

Who wants to move? The role of neighbourhood change

This is the author accepted manuscript. The final version is available from SAGE via http://dx.doi.org/10.1177/0308518X15615367 There is growing interest in how, when and where neighbourhoods affect individual behaviours and outcomes. In Britain, falling levels of owner-occupation and the growth of ethnic minority populations have sparked a debate about how neighbourhood characteristics and neighbourhood change intersect with the decision to move. In this paper we investigate how mobility preferences vary with neighbourhood characteristics and neighbourhood change. We use multilevel logistic regression models to test whether this is configured by personal attributes or attachment to one's neighbourhood and perceived similarity to one's neighbours. The results show that neighbourhood deprivation, changes in neighbourhood ethnic composition and changes in tenure mix are associated with preferring to move. Importantly, we show that a feeling of belonging to the neighbourhood or feeling similar to others in the neighbourhood significantly reduces the desire to move. </jats:p

The moral legitimacy of entrepreneurs: An analysis of early-stage entrepreneurship across 26 countries

This article develops our socio-cultural understanding of entrepreneurship by examining the influence of the moral legitimacy of entrepreneurs upon an individual’s engagement in early-stage entrepreneurship. A multilevel analysis conducted across 26 countries demonstrates that the higher the perceived degree of moral legitimacy, the more likely an individual is to consider starting a business, to begin preparing a business and to progress to actually found and run the business. We conclude that moral norms in society are an important influence upon early-stage entrepreneurship; thus, it is critical to legitimize the position of entrepreneurs as moral and beneficial for society as a whole

Biophysical suitability, economic pressure and land-cover change: a global probabilistic approach and insights for REDD+

There has been a concerted effort by the international scientific community to understand the multiple causes and patterns of land-cover change to support sustainable land management. Here, we examined biophysical suitability, and a novel integrated index of “Economic Pressure on Land” (EPL) to explain land cover in the year 2000, and estimated the likelihood of future land-cover change through 2050, including protected area effectiveness. Biophysical suitability and EPL explained almost half of the global pattern of land cover (R 2 = 0.45), increasing to almost two-thirds in areas where a long-term equilibrium is likely to have been reached (e.g. R 2 = 0.64 in Europe). We identify a high likelihood of future land-cover change in vast areas with relatively lower current and past deforestation (e.g. the Congo Basin). Further, we simulated emissions arising from a “business as usual” and two reducing emissions from deforestation and forest degradation (REDD) scenarios by incorporating data on biomass carbon. As our model incorporates all biome types, it highlights a crucial aspect of the ongoing REDD + debate: if restricted to forests, “cross-biome leakage” would severely reduce REDD + effectiveness for climate change mitigation. If forests were protected from deforestation yet without measures to tackle the drivers of land-cover change, REDD + would only reduce 30 % of total emissions from land-cover change. Fifty-five percent of emissions reductions from forests would be compensated by increased emissions in other biomes. These results suggest that, although REDD + remains a very promising mitigation tool, implementation of complementary measures to reduce land demand is necessary to prevent this leakage

The atmospheric parameters and spectral interpolator for the stars of MILES

Context. Empirical libraries of stellar spectra are used for stellar classification and synthesis of stellar populations. MILES is a medium spectral-resolution library in the optical domain covering a wide range of temperatures, surface gravities and metallicities. Aims. We re-determine the atmospheric parameters of these stars in order to improve the homogeneity and accuracy. We build an interpolating function that returns a spectrum as a function of the three atmospheric parameters, and finally, we characterize the precision of the wavelength calibration and stability of the spectral resolution. Methods. We use the ULySS program with the ELODIE library as a reference and compare the results with literature compilations. Results. We obtain precisions of 60 K, 0.13 and 0.05 dex respectively for Teff, log g and [Fe/H] for the FGK stars. For the M stars, the mean errors are 38 K, 0.26 and 0.12 dex, and for the OBA 3.5%, 0.17 and 0.13 dex. We construct an interpolator that we test against the MILES stars themselves. We test it also by measuring the atmospheric parameters of the CFLIB stars with MILES as reference and find it to be more reliable than the ELODIE interpolator for the evolved hot stars, like in particular those of the blue horizontal branch.Comment: A&A accepted, 29 pages, 6 figure