Automação do acervo Paleontológico da coleção do Museu de Ciências da Terra / DNPM-RJ e sua disponibilização na internet

Resum

Uso terapêutico do CBD na epilepsia: uma revisão integrativa

A utilização medicinal da cannabis remonta a milênios, embora somente recentemente tenham surgido estudos explorando suas propriedades medicinais. O objetivo deste estudo consiste em descrever a eficácia terapêutica do canabidiol (CBD), no tratamento de crises epilépticas, seja como monoterapia ou em conjunto com outros tratamentos. Por meio de uma revisão de cunho integrativo com abordagem qualitativa, quantitativa e descritiva. Foram realizadas buscas nas bases de dados Scientific Electronic Library Online (SCIELO) e National Library of Medicine (PubMed) onde as consultas foram realizadas durante o primeiro semestre de 2024, nos meses de janeiro a junho. e os artigos foram selecionados independentemente por: temática central, levantamento bibliográfico com referência às publicações do recorde temporal, na língua portuguesa e inglesa. Foram incluídos 8 artigos, 4 são estudos experimentais, 3 ensaios clínicos duplo-cego randomizados e 1 ensaio clínico randomizado. Todos os estudos demonstraram melhora na frequência das crises após uso do CBD. Os efeitos adversos mais encontrados foram diarreia, sonolência, fadiga, distúrbios gastrointestinais, hiporexia, diarreia e irritabilidade. Diante desse cenário, os estudos evidenciaram que o uso do CBD se revelou uma opção promissora para aliviar os sintomas clínicos, proporcionando uma melhoria significativa na qualidade de vida dos pacientes afetados por essa condição médica

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Innovation and Use of New Teaching Technologies in Undergraduate Learning and Empowerment for the Labour Market

The present study aims to investigate the perspective of students in the business course on innovation and the use of new teaching technologies in undergraduate learning and empowerment for the labour market in a city in northeastern Brazil. The methodology study is qualitative, conducted through a questionnaire tech-nique with open questions with students from a higher education institution, graduates of the business course and others who have already completed and are looking for space in the labour market. The results obtained in the present study suggest a greater participation of the university in the articulation of its trained professionals with the local companies, serving as a support platform and in this way enabling some monitoring of these graduates at the entrance of the local market, through networks of contacts that bring together companies of recent graduates. The conclusion of the study is that there is a complex situation, that despite the difficulties imposed by the economic crisis and lack of local opportu-nities, the chance of getting a job is better for those who, in fact, absorb as much of the knowledge that the course offers and get their diploma

Núcleos de Ensino da Unesp: artigos 2007

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data