792 research outputs found
A Digital Neuromorphic Architecture Efficiently Facilitating Complex Synaptic Response Functions Applied to Liquid State Machines
Information in neural networks is represented as weighted connections, or
synapses, between neurons. This poses a problem as the primary computational
bottleneck for neural networks is the vector-matrix multiply when inputs are
multiplied by the neural network weights. Conventional processing architectures
are not well suited for simulating neural networks, often requiring large
amounts of energy and time. Additionally, synapses in biological neural
networks are not binary connections, but exhibit a nonlinear response function
as neurotransmitters are emitted and diffuse between neurons. Inspired by
neuroscience principles, we present a digital neuromorphic architecture, the
Spiking Temporal Processing Unit (STPU), capable of modeling arbitrary complex
synaptic response functions without requiring additional hardware components.
We consider the paradigm of spiking neurons with temporally coded information
as opposed to non-spiking rate coded neurons used in most neural networks. In
this paradigm we examine liquid state machines applied to speech recognition
and show how a liquid state machine with temporal dynamics maps onto the
STPU-demonstrating the flexibility and efficiency of the STPU for instantiating
neural algorithms.Comment: 8 pages, 4 Figures, Preprint of 2017 IJCN
The lavender plumage colour in Japanese quail is associated with a complex mutation in the region of MLPH that is related to differences in growth, feed consumption and body temperature
Background
The lavender phenotype in quail is a dilution of both eumelanin and phaeomelanin in feathers that produces a blue-grey colour on a wild-type feather pattern background. It has been previously demonstrated by intergeneric hybridization that the lavender mutation in quail is homologous to the same phenotype in chicken, which is caused by a single base-pair change in exon 1 of MLPH.
Results
In this study, we have shown that a mutation of MLPH is also associated with feather colour dilution in quail, but that the mutational event is extremely different. In this species, the lavender phenotype is associated with a non-lethal complex mutation involving three consecutive overlapping chromosomal changes (two inversions and one deletion) that have consequences on the genomic organization of four genes (MLPH and the neighbouring PRLH, RAB17 and LRRFIP1). The deletion of PRLH has no effect on the level of circulating prolactin. Lavender birds have lighter body weight, lower body temperature and increased feed consumption and residual feed intake than wild-type plumage quail, indicating that this complex mutation is affecting the metabolism and the regulation of homeothermy.
Conclusions
An extensive overlapping chromosome rearrangement was associated with a non-pathological Mendelian trait and minor, non deleterious effects in the lavender Japanese quail which is a natural knockout for PRLH
Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation
Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes. The cycling of retromer on and off the endosomal membrane is regulated by a network of retromer-interacting proteins. Here, we find that Parkinson disease-associated Vps35 variant, R524W, but not P316S, is a loss-of-function mutation as marked by a reduced association with this regulatory network and dysregulation of endosomal receptor sorting. Expression of Vps35 R524W-containing retromer results in the accumulation of intracellular α-synuclein-positive aggregates, a hallmark of Parkinson disease. Overall, the Vps35 R524W-containing retromer has a decreased endosomal association, which can be partially rescued by R55, a small molecule previously shown to stabilize the retromer complex, supporting the potential for future targeting of the retromer complex in the treatment of Parkinson disease
Impacts of warming and elevated CO\u3csub\u3e2\u3c/sub\u3e on a semi-arid grassland are non-additive, shift with precipitation, and reverse over time
It is unclear how elevated CO2 (eCO2) and the corresponding shifts in temperature and precipitation will interact to impact ecosystems over time. During a 7-year experiment in a semi-arid grassland, the response of plant biomass to eCO2 and warming was largely regulated by interannual precipitation, while the response of plant community composition was more sensitive to experiment duration. The combined effects of eCO2 and warming on aboveground plant biomass were less positive in âwetâ growing seasons, but total plant biomass was consistently stimulated by ~ 25% due to unique, supra-additive responses of roots. Independent of precipitation, the combined effects of eCO2 and warming on C3 graminoids became increasingly positive and supraadditive over time, reversing an initial shift toward C4 grasses. Soil resources also responded dynamically and non-additively to eCO2 and warming, shaping the plant responses. Our results suggest grasslands are poised for drastic changes in function and highlight the need for long-term, factorial experiments
Doubt and Excitement:An Experiential Learning Approach to Teaching the Practice of Qualitative Research
Laser-Plasma Interactions Enabled by Emerging Technologies
An overview from the past and an outlook for the future of fundamental
laser-plasma interactions research enabled by emerging laser systems
10 simple rules to create a serious game, illustrated with examples from structural biology
Serious scientific games are games whose purpose is not only fun. In the
field of science, the serious goals include crucial activities for scientists:
outreach, teaching and research. The number of serious games is increasing
rapidly, in particular citizen science games, games that allow people to
produce and/or analyze scientific data. Interestingly, it is possible to build
a set of rules providing a guideline to create or improve serious games. We
present arguments gathered from our own experience ( Phylo , DocMolecules ,
HiRE-RNA contest and Pangu) as well as examples from the growing literature on
scientific serious games
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