696 research outputs found
Participants\u27 Perceptions of Factors in Preventing Falls
Falls pose a serious threat to older adults, often resulting in physical, emotional, and financial consequences. The use of multifactorial fall prevention programs has provided community-dwelling older adults with strategies to decrease the risk of falling. Outcomes for these programs are measured in terms of such factors as fear of falling, balance and self-efficacy. One outcome of fall prevention programs that is less well understood is what the older adults themselves perceive as most beneficial. For this program evaluation project, five women participated in semi-structured interviews to understand which aspects of a multifactorial fall prevention program they found to be most beneficial. Three themes emerged in the interviews: integration of exercises into daily life, implementation of home modification recommendations, and appreciation of volunteer phone calls. Based on these themes, program enhancements were recommended
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung
Mutations in LRRK2 are the most frequent cause of familial Parkinsonâs disease (PD), with common LRRK2 non-coding variants also acting as risk factors for idiopathic PD. Currently, therapeutic agents targeting LRRK2 are undergoing advanced clinical trials in humans, however, it is important to understand the wider implications of LRRK2 targeted treatments given that LRRK2 is expressed in diverse tissues including the brain, kidney and lungs. This presents challenges to treatment in terms of effects on peripheral organ functioning, thus, protein interactors of LRRK2 could be targeted in lieu to optimize therapeutic effects. Herein an in-silico analysis of LRRK2 direct interactors in brain tissue from various brain regions was conducted along with a comparative analysis of the LRRK2 interactome in the brain, kidney, and lung tissues. This was carried out based on curated proteinâprotein interaction (PPI) data from protein interaction databases such as HIPPIE, human gene/protein expression databases and Gene ontology (GO) enrichment analysis using Bingo. Seven targets (MAP2K6, MATK, MAPT, PAK6, SH3GL2, CDC42EP3 and CHGB) were found to be viable objectives for LRRK2 based investigations for PD that would have minimal impact on optimal functioning within peripheral organs. Specifically, MAPT, CHGB, PAK6, and SH3GL2 interacted with LRRK2 in the brain and kidney but not in lung tissue whilst LRRK2-MAP2K6 interacted only in the cerebellum and MATK-LRRK2 interaction was absent in kidney tissues. CDC42EP3 expression levels were low in brain tissues compared to kidney/lung. The results of this computational analysis suggest new avenues for experimental investigations towards LRRK2-targeted therapeutics
Self-Consistent Model of Magnetospheric Electric Field, Ring Current, Plasmasphere, and Electromagnetic Ion Cyclotron Waves: Initial Results
Further development of our self-consistent model of interacting ring current (RC) ions and electromagnetic ion cyclotron (EMIC) waves is presented. This model incorporates large scale magnetosphere-ionosphere coupling and treats self-consistently not only EMIC waves and RC ions, but also the magnetospheric electric field, RC, and plasmasphere. Initial simulations indicate that the region beyond geostationary orbit should be included in the simulation of the magnetosphere-ionosphere coupling. Additionally, a self-consistent description, based on first principles, of the ionospheric conductance is required. These initial simulations further show that in order to model the EMIC wave distribution and wave spectral properties accurately, the plasmasphere should also be simulated self-consistently, since its fine structure requires as much care as that of the RC. Finally, an effect of the finite time needed to reestablish a new potential pattern throughout the ionosphere and to communicate between the ionosphere and the equatorial magnetosphere cannot be ignored
Retrieval of lysosomal membrane and acid phosphatase from phagolysosomes of Paramecium caudatum.
A bounceâaveraged kinetic model of the ring current ion population
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94668/1/grl7966.pd
Quantum Cryptography Based on the Time--Energy Uncertainty Relation
A new cryptosystem based on the fundamental time--energy uncertainty relation
is proposed. Such a cryptosystem can be implemented with both correlated photon
pairs and single photon states.Comment: 5 pages, LaTex, no figure
Quantum geometry of 3-dimensional lattices
We study geometric consistency relations between angles on 3-dimensional (3D)
circular quadrilateral lattices -- lattices whose faces are planar
quadrilaterals inscribable into a circle. We show that these relations generate
canonical transformations of a remarkable ``ultra-local'' Poisson bracket
algebra defined on discrete 2D surfaces consisting of circular quadrilaterals.
Quantization of this structure leads to new solutions of the tetrahedron
equation (the 3D analog of the Yang-Baxter equation). These solutions generate
an infinite number of non-trivial solutions of the Yang-Baxter equation and
also define integrable 3D models of statistical mechanics and quantum field
theory. The latter can be thought of as describing quantum fluctuations of
lattice geometry. The classical geometry of the 3D circular lattices arises as
a stationary configuration giving the leading contribution to the partition
function in the quasi-classical limit.Comment: 27 pages, 10 figures. Minor corrections, references adde
Exponential Distribution of Locomotion Activity in Cell Cultures
In vitro velocities of several cell types have been measured using computer
controlled video microscopy, which allowed to record the cells' trajectories
over several days. On the basis of our large data sets we show that the
locomotion activity displays a universal exponential distribution. Thus, motion
resulting from complex cellular processes can be well described by an
unexpected, but very simple distribution function. A simple phenomenological
model based on the interaction of various cellular processes and finite ATP
production rate is proposed to explain these experimental results.Comment: 4 pages, 3 figure
Specific features of the luminescence and conductivity of zinc selenide on exposure to X-ray and optical excitation
The set of experimental data on the X-ray-excited luminescence and X-ray
induced conductivity of ZnSe are compared to the data on the photoluminescence
and photoconductivity. It is experimentally established that the
current-voltage characteristics and the kinetics of phosphorescence and current
relaxation depend on the type of excitation. It is found that the external
electric field influences the intensity and shape of bands in the luminescence
spectra. It is shown that the character of excitation defines the kinetics of
recombination, charge carrier trapping, and conductivity in wide-gap
semiconductors.Comment: 7 pages, 7 figures, published in Fizika i Tekhnika Poluprovodnikov,
2010, Vol. 44, No. 5, pp. 594-59
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