28 research outputs found
Symmetry-breaking transitions in networks of nonlinear circuit elements
We investigate a nonlinear circuit consisting of N tunnel diodes in series,
which shows close similarities to a semiconductor superlattice or to a neural
network. Each tunnel diode is modeled by a three-variable FitzHugh-Nagumo-like
system. The tunnel diodes are coupled globally through a load resistor. We find
complex bifurcation scenarios with symmetry-breaking transitions that generate
multiple fixed points off the synchronization manifold. We show that multiply
degenerate zero-eigenvalue bifurcations occur, which lead to multistable
current branches, and that these bifurcations are also degenerate with a Hopf
bifurcation. These predicted scenarios of multiple branches and degenerate
bifurcations are also found experimentally.Comment: 32 pages, 11 figures, 7 movies available as ancillary file
Synchronisation in networks of delay-coupled type-I excitable systems
We use a generic model for type-I excitability (known as the SNIPER or SNIC
model) to describe the local dynamics of nodes within a network in the presence
of non-zero coupling delays. Utilising the method of the Master Stability
Function, we investigate the stability of the zero-lag synchronised dynamics of
the network nodes and its dependence on the two coupling parameters, namely the
coupling strength and delay time. Unlike in the FitzHugh-Nagumo model (a model
for type-II excitability), there are parameter ranges where the stability of
synchronisation depends on the coupling strength and delay time. One important
implication of these results is that there exist complex networks for which the
adding of inhibitory links in a small-world fashion may not only lead to a loss
of stable synchronisation, but may also restabilise synchronisation or
introduce multiple transitions between synchronisation and desynchronisation.
To underline the scope of our results, we show using the Stuart-Landau model
that such multiple transitions do not only occur in excitable systems, but also
in oscillatory ones.Comment: 10 pages, 9 figure
Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates
The role of hyperphosphorylation of the microtubule-associated protein tau in the pathological processes of several neurodegenerative diseases is becoming better understood. Consequently, development of new compounds capable of preventing tau hyperphosphorylation is an increasingly hot topic. For this reason, dependable in vitro and in vivo models that reflect tau hyperphosphorylation in human diseases are needed. In this study, we generated and validated an in vitro model appropriate to test potential curative and preventive compound effects on tau phosphorylation. For this purpose, a stably transfected SH-SY5Y cell line was constructed over-expressing mutant human tau441 (SH-SY5Y-TMHT441). Analyses of expression levels and tau phosphorylation status in untreated cells confirmed relevance to human diseases. Subsequently, the effect of different established kinase inhibitors on tau phosphorylation (e.g., residues Thr231, Thr181, and Ser396) was examined. It was shown with several methods including immunosorbent assays and mass spectrometry that the phosphorylation pattern of tau in SH-SY5Y-TMHT441 cells can be reliably modulated by these compounds, specifically targeting JNK, GSK-3, CDK1/5, and CK1. These four protein kinases are known to be involved in in vivo tau phosphorylation and are therefore authentic indicators for the suitability of this new cell culture model for tauopathies
Abstracts of the 33rd International Austrian Winter Symposium : Zell am See, Austria. 24-27 January 2018.
Validation of behavioral phenotypes in the BACHD rat model
Contains fulltext :
221717.pdf (Publisher’s version ) (Closed access
Suppressing noise-induced intensity pulsations in semiconductor lasers by means of time-delayed feedback
Phosphorylation of different tau sites during progression of Alzheimer\u27s disease
Physical-layer network coding (PNC) brings throughput improvement for wireless networks. However, its synchronization requirement is widely recognized as an obstacle to its implementation. In this paper, we focus on phase-level synchronization and propose a time-slotted carrier synchronization scheme for PNC. We then analyze the phase error tolerance of PNC under different bit error rate (BER) requirements, and the synchronization overhead for obtaining synchronous signals below the phase error margin. We also consider the impact of different hardware (in particular, the phase-locked loop) parameters on the overhead in our analysis. Afterwards, we evaluate the performance of the proposed synchronization scheme with simulations. The results show that the proposed scheme is feasible with some typical hardware parameters. The throughput gain of PNC when using the proposed scheme is only slightly lower than the theoretical gain. © 2012 IEEE