Supersymmetric gauge theories on squashed five-spheres and their gravity duals

We construct the gravity duals of large N supersymmetric gauge theories defined on squashed five-spheres with SU(3) x U(1) symmetry. These five-sphere backgrounds are continuously connected to the round sphere, and we find a one-parameter family of 3/4 BPS deformations and a two-parameter family of (generically) 1/4 BPS deformations. The gravity duals are constructed in Euclidean Romans F(4) gauged supergravity in six dimensions, and uplift to massive type IIA supergravity. We holographically renormalize the Romans theory, and use our general result to compute the renormalized on-shell actions for the solutions. The results agree perfectly with the large N limit of the dual gauge theory partition function, which we compute using large N matrix model techniques. In addition we compute BPS Wilson loops in these backgrounds, both in supergravity and in the large N matrix model, again finding precise agreement. Finally, we conjecture a general formula for the partition function on any five-sphere background, which for fixed gauge theory depends only on a certain supersymmetric Killing vector.Comment: 63 pages, no figures; v2: minor corrections and reference adde

Supersymmetric solutions to Euclidean Romans supergravity

We study Euclidean Romans supergravity in six dimensions with a non-trivial Abelian R-symmetry gauge field. We show that supersymmetric solutions are in one-to-one correspondence with solutions to a set of differential constraints on an SU(2) structure. As an application of our results we (i) show that this structure reduces at a conformal boundary to the five-dimensional rigid supersymmetric geometry previously studied by the authors, (ii) find a general expression for the holographic dual of the VEV of a BPS Wilson loop, matching an exact field theory computation, (iii) construct holographic duals to squashed Sasaki-Einstein backgrounds, again matching to a field theory computation, and (iv) find new analytic solutions.Comment: 31 pages; v2: published version (with reference added

Restoration of NK Cell Cytotoxic Function With Elotuzumab and Daratumumab Promotes Elimination of Circulating Plasma Cells in Patients With SLE.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by multiple cellular and molecular dysfunctions of the innate and adaptive immunity. Cytotoxic function of NK cells is compromised in patients with SLE. Herein, we characterized the phenotypic alterations of SLE NK cells in a comprehensive manner to further delineate the mechanisms underlying the cytotoxic dysfunction of SLE NK cells and identify novel potential therapeutic targets. Therefore, we examined PBMC from SLE patients and matched healthy controls by single-cell mass cytometry to assess the phenotype of NK cells. In addition, we evaluated the cell function of NK cells (degranulation and cytokine production) and the killing of B cell subpopulations in a B cell-NK cell in vitro co-culture model. We found that SLE NK cells expressed higher levels of CD38 and were not able to adequately upregulate SLAMF1 and SLAMF7 following activation. In addition, ligation of SLAMF7 with elotuzumab or of CD38 with daratumumab on SLE NK cells enhanced degranulation of both healthy and SLE NK cells and primed them to kill circulating plasma cells in an in vitro co-culture system. Overall, our data indicated that dysregulated expression of CD38, SLAMF1 and SLAMF7 on SLE NK cells is associated with an altered interplay between SLE NK cells and plasma cells, thus suggesting their contribution to the accumulation of (auto)antibody producing cells. Accordingly, targeting SLAMF7 and CD38 may represent novel therapeutic approaches in SLE by enhancing NK cell function and promoting elimination of circulating plasma cell

The large N limit of M2-branes on Lens spaces

We study the matrix model for N M2-branes wrapping a Lens space L(p,1) = S^3/Z_p. This arises from localization of the partition function of the ABJM theory, and has some novel features compared with the case of a three-sphere, including a sum over flat connections and a potential that depends non-trivially on p. We study the matrix model both numerically and analytically in the large N limit, finding that a certain family of p flat connections give an equal dominant contribution. At large N we find the same eigenvalue distribution for all p, and show that the free energy is simply 1/p times the free energy on a three-sphere, in agreement with gravity dual expectations.Comment: 28 pages, 4 figure

Innate Lymphoid Cells in Autoimmune Diseases.

Innate lymphoid cells (ILC) are a heterogeneous group of immune cells characterized by lymphoid morphology and cytokine profile similar to T cells but which do not express clonally distributed diverse antigen receptors. These particular cells express transcription factors and cytokines reflecting their similarities to T helper (Th)1, Th2, and Th17 cells and are therefore referred to as ILC1, ILC2, and ILC3. Other members of the ILC subsets include lymphoid tissue inducer (LTi) and regulatory ILC (ILCreg). Natural killer (NK) cells share a common progenitor with ILC and also exhibit a lymphoid phenotype without antigen specificity. ILC are found in low numbers in peripheral blood but are much more abundant at barrier sites such as the skin, liver, airways, lymph nodes, and the gastrointestinal tract. They play an important role in innate immunity due to their capacity to respond rapidly to pathogens through the production of cytokines. Recent evidence has shown that ILC also play a key role in autoimmunity, as alterations in their number or function have been identified in systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Here, we review recent advances in the understanding of the role of ILC in the pathogenesis of autoimmune diseases, with particular emphasis on their role as a potential diagnostic biomarker and as therapeutic targets

SLAMF Receptor Expression Identifies an Immune Signature That Characterizes Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, linked to alterations in both the innate and the adaptive immune system. Due to the heterogeneity of the clinical presentation, the diagnosis of SLE remains complicated and is often made years after the first symptoms manifest, delaying treatment, and worsening the prognosis. Several studies have shown that signaling lymphocytic activation molecule family (SLAMF) receptors are aberrantly expressed and dysfunctional in SLE immune cells, contributing to the altered cellular function observed in these patients. The aim of this study was to determine whether altered co-/expression of SLAMF receptors on peripheral blood mononuclear cells (PBMC) identifies SLE characteristic cell populations. To this end, single cell mass cytometry and bioinformatic analysis were exploited to compare SLE patients to healthy and autoimmune diseases controls. First, the expression of each SLAMF receptor on all PBMC populations was investigated. We observed that SLAMF1+ B cells (referred to as SLEB1) were increased in SLE compared to controls. Furthermore, the frequency of SLAMF4+ monocytes and SLAMF4+ NK were inversely correlated with disease activity, whereas the frequency SLAMF1+ CD4+ TDEM cells were directly correlated with disease activity. Consensus clustering analysis identified two cell clusters that presented significantly increased frequency in SLE compared to controls: switch memory B cells expressing SLAMF1, SLAMF3, SLAMF5, SLAMF6 (referred to as SLESMB) and circulating T follicular helper cells expressing the same SLAMF receptors (referred to as SLEcTFH). Finally, the robustness of the identified cell populations as biomarkers for SLE was evaluated through ROC curve analysis. The combined measurement of SLEcTFH and SLEB1 or SLESMB cells identified SLE patients in 90% of cases. In conclusion, this study identified an immune signature for SLE based on the expression of SLAMF receptors on PBMC, further highlighting the involvement of SLAMF receptors in the pathogenesis of SLE

The Control System for the Cryogenics in the LHC Tunnel [First Experience and Improvements]

The Large Hadron Collider (LHC) was commissioned at CERN and started operation with beams in 2008. Several months of operation in nominal cryogenic conditions have triggered an optimisation of the process functional analysis. This lead to a few revisions of the control logic, which were realised on-the-fly. During the 2008-09 shut-down, and in order to enhance the safety, availability and operability of the LHC cryogenics, a major rebuild of the logic and several hardware modifications were implemented. The databases, containing instruments and controls in-formation, are being rationalized; the automatic tool, that extracts data for the control software, is being simplified. This paper describes the main improvements and sug-gests perspectives of further developments

Reception Tests of the Cryogenic Distribution line for the Large Hadron Collider

The paper describes the thermo-mechanical validation of the first sector of cryogenic distribution line (QRL) [1]. The design of the line is recalled and the test methodology presented together with the main results of the reception test at cryogenic temperature

Perioperative and long-term operative outcomes after surgery for trigeminal neuralgia: microvascular decompression vs percutaneous balloon ablation

<p>Abstract</p> <p>Objectives</p> <p>Numerous medical and surgical therapies have been utilized to treat the symptoms of trigeminal neuralgia (TN). This retrospective study compares patients undergoing either microvascular decompression or balloon ablation of the trigeminal ganglion and determines which produces the best long-term outcomes.</p> <p>Methods</p> <p>A 10-year retrospective chart review was performed on patients who underwent microvascular decompression (MVD) or percutaneous balloon ablation (BA) surgery for TN. Demographic data, intraoperative variables, length of hospitalization and symptom improvement were assessed along with complications and recurrences of symptoms after surgery. Appropriate statistical comparisons were utilized to assess differences between the two surgical techniques.</p> <p>Results</p> <p>MVD patients were younger but were otherwise similar to BA patients. Intraoperatively, twice as many BA patients developed bradycardia compared to MVD patients. 75% of BA patients with bradycardia had an improvement of symptoms. Hospital stay was shorter in BA patients but overall improvement of symptoms was better with MVD. Postoperative complication rates were similar (21% vs 26%) between the BA and MVD groups.</p> <p>Discussion</p> <p>MVD produced better overall outcomes compared to BA and may be the procedure of choice for surgery to treat TN.</p

Equal pay by gender and by nationality: a comparative analysis of Switzerland's unequal equal pay policy regimes across time

What explains the adoption of two different policies on equal pay by gender (EPG) and by nationality (EPN) in Switzerland? And why is the liberal, litigation-based, equal pay policy regime set up by the Gender Equality Act of 1996 much less effective than the neocorporatist ‘accompanying measures' to the Bilateral European Union-Switzerland Agreement on Free Movement of Persons adopted in 1999 to ensure equal pay for workers of different national origins? The formation of two different policy regimes cannot be explained by different levels of political will. Equally, different ‘varieties of capitalism' cannot explain the setup of the two different equal pay policy regimes within the very same country. Instead, our qualitative comparative analysis across time suggests that the differences can be best explained by a particular constellation of attributes, namely the use of different policy frames—i.e. ‘anti-discrimination' in the EPG and ‘unfair competition' in the EPN case—and the different setting of interest politics epitomised by the opposite stances adopted by Switzerland's employer associations in the two case