11 research outputs found
t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML
Mortality by causes in HIV-infected adults: comparison with the general population
<p>Abstract</p> <p>Background</p> <p>We compared mortality by cause of death in HIV-infected adults in the era of combined antiretroviral therapy with mortality in the general population in the same age and sex groups.</p> <p>Methods</p> <p>Mortality by cause of death was analyzed for the period 1999-2006 in the cohort of persons aged 20-59 years diagnosed with HIV infection and residing in Navarre (Spain). This was compared with mortality from the same causes in the general population of the same age and sex using standardized mortality ratios (SMR).</p> <p>Results</p> <p>There were 210 deaths among 1145 persons diagnosed with HIV (29.5 per 1000 person-years). About 50% of these deaths were from AIDS. Persons diagnosed with HIV infection had exceeded all-cause mortality (SMR 14.0, 95% CI 12.2 to 16.1) and non-AIDS mortality (SMR 6.9, 5.7 to 8.5). The analysis showed excess mortality from hepatic disease (SMR 69.0, 48.1 to 78.6), drug overdose or addiction (SMR 46.0, 29.2 to 69.0), suicide (SMR 9.6, 3.8 to 19.7), cancer (SMR 3.2, 1.8 to 5.1) and cardiovascular disease (SMR 3.1, 1.3 to 6.1). Mortality in HIV-infected intravenous drug users did not change significantly between the periods 1999-2002 and 2003-2006, but it declined by 56% in non-injecting drug users (<it>P </it>= 0.007).</p> <p>Conclusions</p> <p>Persons with HIV infection continue to have considerable excess mortality despite the availability of effective antiretroviral treatments. However, excess mortality in the HIV patients has declined since these treatments were introduced, especially in persons without a history of intravenous drug use.</p
Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Pamplona, 1991-95
FUNDAMENTO: evaluar el impacto a corto plazo de la contaminación atmosférica sobre la mortalidad diaria de la ciudad de Pamplona MÉTODO: Estudio ecológico con una población de 212.000 habitantes. Se realiza análisis de datos de series temporales, mediante regresión lineal múltiple y regresión de Poisson, con la información de datos de mortalidad diaria, niveles de contaminación atmosférica para Partículas y SO2, parámetros meterológicos de temperatura y humedad media diarios y número de casos semanales de gripe, en los años 1991 a 1995 RESULTADOS: La media de muertes diarias por causas no externas es de 4,15 muertos con un rango de cero a 13 muertes. La ciudad de Pamplona tiene una temperatura media anual de 12,7ºC (-2,3ºC a 31.6ºC) y una humedad relativa del 68.5%. En el modelo, la temperatura (con retardo de un día y retardo de 6 días temperatura al cuadrado) y la humedad (con retardo de un día) esta relacionada con la mortalidad por todas las causas. Pero la mortalidad por causas no externas sólo se relaciona en el modelo con la temperatura (retardo un día, P: 0.035) y cinco días con temperatura al cuadrado (p: 0.028) Las estimaciones puntuales del riesgo relativo de partículas muestran que el máximo riesgo de morir se produce en las causas respiratorias con un riesgo relativo de 1.13. Sin embargo ninguna de estas asociaciones es estadísticamente significativa. En el caso de Dióxido de Azufre las estimaciones están muy próximas al valor nulo y ninguna de ellas es significativa. CONCLUSIONES: la Temperatura tiene efecto sobre la mortalidad por todas las causas tanto externas como no externas y la humedad solo tienen efecto sobre la mortalidad por causas no externas. No se ha podido demostrar una influencia de los niveles diarios de contaminación ambiental sobre la mortalidad diaria.Background: To assess the short-term impact of air pollution
on the daily death rate in the City of Pamplona.
Method: Ecological study with a population of 212,000 inhabitants.
A time series data analysis is conducted by means of
multiple linear regression and Poisson regression, with the
daily death rate data, air pollution levels for Particles and S02,
weather parameters of average relative humidity and temperature
daily and number of cases weekly of flu for the 1991-1995
period.
Results: The average number of deaths daily for
non-externa1 causes is that of 4.15 deaths, with a range from
zero to 13 deaths. The city of Pamplona has a mean annual temperature
of 12.7” C (-2.3” C to 3 1.6” C) and a relative humidity
of 68.5%. In the model, the temperature (with a one-day time
lag and a six-day time lag temperature squared) and the humidity
(with a one-day time lag) is related to the death rate for al1
causes. But the death rate for non-externa1 causes is only related
in the model with the temperature (one-day time lag,
P:O.O35) and five-day time lag with temperature squared (p:
0.028).
The timely estimates of the relative particle-related risk
show that the highest risk of dying stems from respiratory causes
with a relative risk of 1.13. However, none of these relationships
is statistically signifícant. In the case of Sulfur Dioxide,
the estimates closely near the zero figure, and none of them
is significant.
Conclusions: The Temperature has an impact of the death
rate for al1 causes, both externa1 and non-extemal, and the relative
humidity solely has an impact on the death rate for
non-externa1 causes. It has not been possible to prove any influente
of the daily enviromnental pollution levels on the daily
death rate
Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en Pamplona, 1991-95
FUNDAMENTO: evaluar el impacto a corto plazo de la contaminación atmosférica sobre la mortalidad diaria de la ciudad de Pamplona MÉTODO: Estudio ecológico con una población de 212.000 habitantes. Se realiza análisis de datos de series temporales, mediante regresión lineal múltiple y regresión de Poisson, con la información de datos de mortalidad diaria, niveles de contaminación atmosférica para Partículas y SO2, parámetros meterológicos de temperatura y humedad media diarios y número de casos semanales de gripe, en los años 1991 a 1995 RESULTADOS: La media de muertes diarias por causas no externas es de 4,15 muertos con un rango de cero a 13 muertes. La ciudad de Pamplona tiene una temperatura media anual de 12,7ºC (-2,3ºC a 31.6ºC) y una humedad relativa del 68.5%. En el modelo, la temperatura (con retardo de un día y retardo de 6 días temperatura al cuadrado) y la humedad (con retardo de un día) esta relacionada con la mortalidad por todas las causas. Pero la mortalidad por causas no externas sólo se relaciona en el modelo con la temperatura (retardo un día, P: 0.035) y cinco días con temperatura al cuadrado (p: 0.028) Las estimaciones puntuales del riesgo relativo de partículas muestran que el máximo riesgo de morir se produce en las causas respiratorias con un riesgo relativo de 1.13. Sin embargo ninguna de estas asociaciones es estadísticamente significativa. En el caso de Dióxido de Azufre las estimaciones están muy próximas al valor nulo y ninguna de ellas es significativa. CONCLUSIONES: la Temperatura tiene efecto sobre la mortalidad por todas las causas tanto externas como no externas y la humedad solo tienen efecto sobre la mortalidad por causas no externas. No se ha podido demostrar una influencia de los niveles diarios de contaminación ambiental sobre la mortalidad diaria.Background: To assess the short-term impact of air pollution
on the daily death rate in the City of Pamplona.
Method: Ecological study with a population of 212,000 inhabitants.
A time series data analysis is conducted by means of
multiple linear regression and Poisson regression, with the
daily death rate data, air pollution levels for Particles and S02,
weather parameters of average relative humidity and temperature
daily and number of cases weekly of flu for the 1991-1995
period.
Results: The average number of deaths daily for
non-externa1 causes is that of 4.15 deaths, with a range from
zero to 13 deaths. The city of Pamplona has a mean annual temperature
of 12.7” C (-2.3” C to 3 1.6” C) and a relative humidity
of 68.5%. In the model, the temperature (with a one-day time
lag and a six-day time lag temperature squared) and the humidity
(with a one-day time lag) is related to the death rate for al1
causes. But the death rate for non-externa1 causes is only related
in the model with the temperature (one-day time lag,
P:O.O35) and five-day time lag with temperature squared (p:
0.028).
The timely estimates of the relative particle-related risk
show that the highest risk of dying stems from respiratory causes
with a relative risk of 1.13. However, none of these relationships
is statistically signifícant. In the case of Sulfur Dioxide,
the estimates closely near the zero figure, and none of them
is significant.
Conclusions: The Temperature has an impact of the death
rate for al1 causes, both externa1 and non-extemal, and the relative
humidity solely has an impact on the death rate for
non-externa1 causes. It has not been possible to prove any influente
of the daily enviromnental pollution levels on the daily
death rate
t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML
Papilomavirus con terapia fotodinámica en la consulta de enfermería dermatológica (ceder)
Assessing the effect of environmental and anthropogenic factors on land-cover diversity in a Mediterranean mountain environment
Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: Influence of dose and stem cell source shows better outcome with rich marrow
Several studies have compared bone marrow (BM) and peripheral blood (PB) as stem cell sources in patients receiving allografts, but the cell doses infused have not been considered, especially for BM. Using the ALWP/EBMT registry, we retrospectively studied 881 adult patients with acute myelocytic leukemia (AML), who received a non-T-depleted allogeneic BM (n = 515) or mobilized PB (n = 366) standard transplant, in first remission (CR1), from an HLA-identical sibling, over a 5-year period from January 1994. The BM cell dose ranged from 0.17 to 29 × 108/kg with a median of 2.7 × 108/kg. The PB cell dose ranged from 0.02 to 77 × 10 8/kg with a median of 9.3 × 108/kg. The median dose for patients receiving BM (2.7 × 108/kg) gave the greatest discrimination. In multivariate analyses, high-dose BM compared to PB was associated with lower transplant-related mortality (RR = 0.61; 95% CI, 0.39-0.98; P = .04), better leukemia-free survival (RR = 0.65; 95% CI, 0.46-0.91; P = .013), and better overall survival (RR = 0.64; 95% CI, 0.44-0. 92; P = .016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich. © 2003 by The American Society of Hematology