Energy Conversion Alternatives Study (ECAS), General Electric Phase 1. Volume 2: Advanced Energy Conversion Systems. Part 2: Closed Turbine Cycles

For abstract, see N76-23680

Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells.

Myosin VIIA is expressed by sensory hair cells and has a primary structure predicting a role in membrane trafficking and turnover, processes that may underlie the susceptibility of hair cells to aminoglycoside antibiotics. [3H]Gentamicin accumulation and the effects of aminoglycosides were therefore examined in cochlear cultures of mice with different missense mutations in the myosin VIIA gene, Myo7a, to see whether myosin VIIA plays a role in aminoglycoside ototoxicity. Hair cells from homozygous mutant Myo7a(sh1) mice, with a mutation in a non-conserved region of the myosin VIIA head, respond rapidly to aminoglycoside treatment and accumulate high levels of gentamicin. Hair cells from homozygous mutant Myo7a(6J) mice, with a mutation at a highly conserved residue close to the ATP binding site of the myosin VIIA head, do not accumulate [3H]gentamicin and are protected from aminoglycoside ototoxicity. Hair cells from heterozygotes of both alleles accumulate [3H]gentamicin and respond to aminoglycosides. Although aminoglycoside uptake is thought to be via apical surface-associated endocytosis, coated pit numbers on the apical membrane of heterozygous and homozygous Myo7a(6J) hair cells are similar. Pulse-chase experiments with cationic ferritin confirm that the apical endocytotic pathway is functional in homozygous Myo7a(6J) hair cells. Transduction currents can be recorded from both heterozygous and homozygous Myo7a(6J) hair cells, suggesting it is unlikely that the drug enters via diffusion through the mechanotransducer channel. The results show that myosin VIIA is required for aminoglycoside accumulation in hair cells. Myosin VIIA may transport a putative aminoglycoside receptor to the hair cell surface, indirectly translocate it to sites of membrane retrieval, or retain it in the endocytotic pathway

Data gathering and architecture aspects of a major EU wide energy efficiency project for SMEs

“Support and Training for an Excellent Energy Efficiency Performance” is a 3-year European project helping over 600 European cross-sector small and medium sized enterprises (SMEs) to reduce their energy use and become more energy-efficient. Companies participating in STEEEP benefit from tailored training and guidance on effective energy management tools and best practices provided by an established network of energy advisors from Chambers of Commerce and Industry (CCIs) in 10 different countries. SMEs in many EU countries employ over 90% of the workforce, so improving the energy efficiency of EU SMEs is therefore compelling, with clear advantages for the European economy. Energy efficiency in SMEs previously received less attention than in larger companies, the public sector and dwellings. Previously, policymakers had little energy (and related) data for SMEs, making prioritising ways to support energy conservation difficult. In addition staffing resources and knowledge levels within SMEs frequently determine the level of commitment to energy efficiency and implementing EU energy and climate policy, with a dedicated or even part time energy manager for many SMEs a rarity. The STEEEP project aims to help this by introducing training to SMEs via CCIs, and monitoring savings and providing feedback to SMEs. Crucial to this is the benchmarking of energy use: Basic data about the SMEs, the SME’s energy consumption, and information about the SME policies and procedures relating to energy were gathered form each of the over 600 participants. Managing these data is a considerable task, notably in several languages, using combinations of numeric, free text and other data, gathered through questionnaires. It is not merely fiscal metering data, and supporting information that are gathered, we ask for from occupancy, to building types, and to complete the energy management matrix. We describe how this is done; the data processing . survey design, initial data gathering, benchmarking, and database architecture. Energy use is gathered as the project progresses , with interventions and changes captured. This paper describes the methods used and presents lessons learnt. This include the process of collecting , storing and analyzing the data from over 600 SMEs in 10 different countries. It identifies how barriers were overcome and how information from the data collection is being used by Chambers of Commerce and Industry to help reduce energy use of SME

A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injury

We tested the hypothesis that a selective phosphodiesterase type 4 inhibitor (PDE4-I; IC486051) would attenuate early inflammatory and oxidative processes following spinal cord injury (SCI) when delivered during the first 3 days after injury. Rats receiving a moderately severe thoracic-clip-compression SCI were treated with the PDE4-I (0.5, 1.0, and 3.0 mg/kg IV) in bolus doses from 2-60 h post-injury. Doses at 0.5 mg/kg and 1.0 mg/kg significantly decreased myeloperoxidase (MPO) enzymatic activity (neutrophils), expression of a neutrophil-associated protein and of ED-1 (macrophages), and estimates of lipid peroxidation in cord lesion homogenates at 24 h and 72 h post-injury by 25-40%. The 3.0 mg/kg dose had small or no effects on these measures. The PDE4-I treatment (0.5 or 1.0 mg/kg) reduced expression of the oxidative enzymes gp91phox, inducible nitric oxide synthase, and cyclooxygenase-2, and diminished free radical generation by up to 40%. Treatment with 0.5 mg/kg PDE4-I improved motor function (as assessed by the Basso-Beattie-Bresnahan scale) significantly from 4-8 weeks after SCI (average difference 1.3 points). Mechanical allodynia elicited from the hindpaw decreased by up to 25%. The PDE4-I treatment also increased white matter volume near the lesion at 8 weeks after SCI. In conclusion, the PDE4-I reduced key markers of oxidative stress and leukocyte infiltration, producing cellular protection, locomotor improvements, and a reduction in neuropathic pain. Early inhibition of PDE4 is neuroprotective after SCI when given acutely and briefly at sufficient doses. © 2011, Mary Ann Liebert, Inc

General hardware multicasting for fine-grained message-passing architectures

Manycore architectures are increasingly favouring message-passing or partitioned global address spaces (PGAS) over cache coherency for reasons of power efficiency and scalability. However, in the absence of cache coherency, there can be a lack of hardware support for one-to-many communication patterns, which are prevalent in some application domains. To address this, we present new hardware primitives for multicast communication in rack-scale manycore systems. These primitives guarantee delivery to both colocated and distributed destinations, and can capture large unstructured communication patterns precisely. As a result, reliable multicast transfers among any number of software tasks, connected in any topology, can be fully offloaded to hardware. We implement the new primitives in a research platform consisting of 50K RISC-V threads distributed over 48 FPGAs, and demonstrate significant performance benefits on a range of applications expressed using a high-level vertex-centric programming model

Meteor light curves: the relevant parameters

We investigate a uniform sample of 113 light curves (LCs) of meteors collected at the Wise Observatory in November 2002 while observing the Leonid meteor shower. We use previously defined descriptors such as the skewness F and a recently defined pointedness parameter along with a number of other measurable or derived quantities to explore the parameter space in search of meaningful LC descriptors. We make extensive use of statistical techniques to reveal links among the variables and to understand their relative importance. In particular, we show that meteors with long-duration trails rise slowly to their maximal brightness and also decay slowly from there while showing milder flaring than other meteors. Early skewed LCs show a fast rise to the peak. We show that the duration of te luminous phase of the meteor is th emost important variable differentiating among the 2002 LCs. The skewness parameter F appears only as the 2nd or 3rd in explaining the LC variance. We suggest that the pointedness parameter P could possibly be useful to discriminate among meteors from different showers, or to compare observations and model predictions.Comment: 10 pages (2 figures) in press with MNRA

Web-based glacial and bedrock geologic map products and databases for Marion County, Indiana

This poster was presented at the 2010 meeting of the North-Central and South-Central Sections of the Geological Society of America, 44th Annual Meeting, in Branson, MO, April 11-13, 2010.The Internet has become a medium of choice for delivering geologic information to both technical users and the general public. The Indiana Geological Survey (IGS) is creating a Web-based glacial and bedrock geologic map site for Marion County in central Indiana to provide detailed geologic information needed to address environmental and resource management issues related to a growing population and land-use conflicts. Marion County is the location of Indianapolis, the state capital and largest city. The IGS anticipates that the information available via the Web site will be widely used by the general public, industry, and government entities concerned about the geology, groundwater, and other natural resources in this county. The Marion County Web site links an Internet map server (IMS) and database to provide a portal to the IGS’s enterprise geodatabases that allows users to efficiently create, manage, update, and distribute maps and data. The IMS site retrieves maps and cross sections of Marion County completed during earlier IGS mapping projects. Map layers pertaining to bedrock geology, surficial geology, hydrology, infrastructure, and imagery are included. Database information includes (1) lithologic information compiled from water-well records stored in the Indiana Department of Natural Resources, Division of Water archives, (2) natural gamma-ray geophysical log data, (3) stratigraphic test hole data, and (4) petroleum-well-record data. The development of the Web site is funded by the IGS and the Great Lakes Geologic Mapping Coalition.Great Lakes Geologic Mapping Coalitio

Tales from the playing field: black and minority ethnic students' experiences of physical education teacher education

This article presents findings from recent research exploring black and minority ethnic (BME) students’ experiences of Physical Education teacher education (PETE) in England (Flintoff, 2008). Despite policy initiatives to increase the ethnic diversity of teacher education cohorts, BME students are under-represented in PETE, making up just 2.94% of the 2007/8 national cohort, the year in which this research was conducted. Drawing on in-depth interviews and questionnaires with 25 BME students in PETE, the study sought to contribute to our limited knowledge and understanding of racial and ethnic difference in PE, and to show how ‘race,’ ethnicity and gender are interwoven in individuals’ embodied, everyday experiences of learning how to teach. In the article, two narratives in the form of fictional stories are used to present the findings. I suggest that narratives can be useful for engaging with the experiences of those previously silenced or ignored within Physical Education (PE); they are also designed to provoke an emotional as well as an intellectual response in the reader. Given that teacher education is a place where we should be engaging students, emotionally and politically, to think deeply about teaching, education and social justice and their place within these, I suggest that such stories of difference might have a useful place within a critical PETE pedagogy

Web-Based Geologic Maps, Databases, and HTML Pages for Marion County, Indiana

This poster was presented at the 2011 meeting of the Indiana Academy of Science, 126th Annual Academy Meeting, March 4-5, 2011, Indianapolis, Indiana.The Indiana Geological Survey (IGS) has created an internet map server for Marion County in central Indiana. The site provides detailed geologic information needed to address environmental issues, resource management issues, and land-use conflicts related to a growing population. Marion County is the location of Indianapolis, the state capital and largest city. The IGS anticipates that the Web site will be widely used by the general public, industry, and government entities concerned about the geology, groundwater, and other natural resources. The Marion County Web site links an Internet map server (IMS) and database to provide a portal to the IGS‘s enterprise geodatabases, which allow users to efficiently create, manage, update, and distribute maps and data. The IMS site retrieves maps of bedrock and surficial geology completed during earlier IGS mapping projects. Hydrogeology, infrastructure, and imagery map layers are also included. Database information includes lithologic information (iLITH) compiled from water-well records stored in the Indiana Department of Natural Resources, Division of Water archives and natural gamma-ray geophysical log data, stratigraphic test hole data, and petroleum well-record data from the IGS. Currently, the following products are being prepared: (1) illustrated Web pages discussing the surficial geology, bedrock geology, and bedrock topography; (2) illustrated Web pages discussing digital elevation model terrain, gamma-ray log, iLITH, and clay thickness data sets; (3) online glossary; and (4) metadata for the map layers. The development of the Web site is funded by the IGS and the Great Lakes Geologic Mapping Coalition.Great Lakes Geologic Mapping Coalitio

High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

We thank The Development Trust, University of Aberdeen, for financial support and a fellowship to M.P. The work was also supported by the CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester (KJW Co-I; reference 16465). We thank Dr Massimiliano Baldassarre (University of Aberdeen) for helpful discussions.Peer reviewedPostprin