Examining Recent Expert Elicitation Judgment Guidelines: Value Assumptions and the Prospects for Rationality

This paper was presented at the VALDOR Symposium, Stockholm, June 1999. The author examines the value assumptions in the U.S. Department of Energy and Nuclear Regulatory Commission guidance on the use of expert judgment relating to high level nuclear waste disposal site selection

The relation of perceptual factors and speed of handwriting to spelling ability.

Thesis (Ed.M.)--Boston Universit

Response to Wolf et al.: Furthering Debate over the Suitability of Trap-Neuter-Return for Stray Cat Management

To continue dialogue over proposed Australian trials of Trap-Neuter-Return (TNR), we applied a framework requiring identification of areas of agreement, areas of disagreement, and identification of empirical data collection required to resolve disagreements. There is agreement that Australia has a problem with stray cats, causing problems of impacts on wildlife, nuisance,disease transmission (including public health issues and exchange of diseases between stray cat and pet cat populations), poor welfare outcomes for stray cats, and an emotional burden on staff euthanising healthy stray cats. There is disagreement on whether (i) current measures are failing, leading to unacceptably high euthanasia levels, (ii) some contributors to the debate misunderstand TNR, (iii) TNR trials will reduce urban cat populations and associated problems, (iv) TNR is an ethical solution to cat overpopulation, and (v) some contributors to the debate promulgated misinformation. Although not everyone agrees that TNR trials should proceed, as a hypothetical exploration, we propose an experimental approach explicitly comparing TNR to alternatives. Trials could only be considered if other detailed and well-funded attempts at stray cat control focusing across an entire Local Government Area (LGA) prove ineffective

A Case of Letting the Cat out of the Bag - Why Trap-Neuter-Return is Not an Ethical Solution for Stray Cat (Felis Catus) Management.

Trap-Neuter-Return (TNR) programs, in which stray cats are captured, neutered and returned to the environment are advocated as a humane, ethical alternative to euthanasia. We review the TNR literature in light of current debate over whether or not there should be further TNR trials in Australia. We revisit the problems arising from stray cats living in association with human habitation and estimate how many stray cats would have to be processed through a scientifically-guided TNR program to avoid high euthanasia rates. We also identify10 ethical and welfare challenges that have to be addressed: we consider the quality of life for stray cats, where they would live, whether the TNR process itself is stressful, whether TNR cats are vulnerable to injury, parasites and disease, can be medically treated, stray cats’ body condition and diet, and their impacts on people, pet cats, and urban wildlife, especially endemic fauna. We conclude that TNR is unsuitable for Australia in almost all situations because it is unlikely to resolve problems caused by stray cats or meet ethical and welfare challenges. Targeted adoption, early-age desexing, community education initiatives and responsible pet ownership have greater promise to minimize euthanasia, reduce numbers rapidly, and address the identified issues

Gene Expression Analysis of In Vitro Cocultures to Study Interactions between Breast Epithelium and Stroma

The interactions between breast epithelium and stroma are fundamental to normal tissue homeostasis and for tumor initiation and progression. Gene expression studies of in vitro coculture models demonstrate that in vitro models have relevance for tumor progression in vivo. For example, stromal gene expression has been shown to vary in association with tumor subtype in vivo, and analogous in vitro cocultures recapitulate subtype-specific biological interactions. Cocultures can be used to study cancer cell interactions with specific stromal components (e.g., immune cells, fibroblasts, endothelium) and different representative cell lines (e.g., cancer-associated versus normal-associated fibroblasts versus established, immortalized fibroblasts) can help elucidate the role of stromal variation in tumor phenotypes. Gene expression data can also be combined with cell-based assays to identify cellular phenotypes associated with gene expression changes. Coculture systems are manipulable systems that can yield important insights about cell-cell interactions and the cellular phenotypes that occur as tumor and stroma co-evolve

Intermittent attendance at breast cancer screening

Background. To determine why women skip rounds and factors influencing return of previous non attenders (PNAs) to breast screening. Design and methods. Retrospective, quantitative, structured questionnaire posted to 2500 women. First PNAs did not attend their first screening appointment in 2007/2008 but then attended in 2010; First Controls first attended in 2010 without missed previous appointments. Women who attended screening in 2006 or earlier then skipped a round but returned in 2010 were Subsequent PNAs; Subsequent Controls attended all appointments.Results. More First Controls than First PNAs had family history of cancer (72.7% vs 63.2%; P=0.003); breast cancer (31.3% vs 24.8%; P=0.04). More PNAs lived rurally; more First PNAs had 3rd level education (33.2% vs 23.6%; P=0.002) and fewer had private insurance than First Controls (57.7% vs 64.8%; P=0.04). Excellent/good health was reported in First PNAs and First Controls (82.9% vs 83.2%), but fewer Subsequent PNAs than Subsequent Controls (72.7% vs 84.9%; P=0.000). Common considerations at time of missed appointment were had mammogram elsewhere (33% First PNA) and postponed to next round (16% First PNA, 18.8% Subsequent PNA). Considerations when returning to screening were similar for First PNAs and Subsequent PNAs: I am older (35.4%, 29.6%), I made sure I remembered (29%, 23.6%), could reschedule (17.6%, 20.6%), illness of more concern (16.5%, 19%). More First PNAs stated my family/friends advised (22.3% vs 15.2%) or my GP (12.6% vs 4.6%) advised me to attend, heard good things about BreastCheck (28.8% vs 13.6%).Conclusions. Intermittent attenders do not fit socio-demographic patterns of non-attenders; GP recommendation and word of mouth were important in women’s return to screening. Fear and anxiety seem to act as a screening facilitator rather than an inhibitor

Human factors and patient safety in undergraduate healthcare education : A systematic review

Peer reviewedPublisher PD

Body Size and Bite Force of Stray and Feral Cats - Are Bigger or Older Cats Taking the Largest or More Difficult to Handle Prey

As carnivorans rely heavily on their head and jaws for prey capture and handling, skull morphology and bite force can therefore reflect their ability to take larger or more difficult-to-handle prey. For 568 feral and stray cats (Felis catus), we recorded their demographics (sex and age), source location (feral or stray) and morphological measures (body mass, body condition); we estimated potential bite force from skull measurements for n = 268 of these cats, and quantified diet composition from stomach contents for n = 358. We compared skull measurements to estimate their bite force and determine how it varied with sex, age, body mass, body condition. Body mass had the strongest influence of bite force. In our sample, males were 36.2% heavier and had 20.0% greater estimated bite force (206.2 ± 44.7 Newtons, n = 168) than females (171.9 ± 29.3 Newtons, n = 120). However, cat age was the strongest predictor of the size of prey that they had taken, with older cats taking larger prey. The predictive power of this relationship was poor though (r2 \u3c 0.038, p \u3c 0.003), because even small cats ate large prey and some of the largest cats ate small prey, such as invertebrates. Cats are opportunistic, generalist carnivores taking a broad range of prey. Their ability to handle larger prey increases as the cats grow, increasing their jaw strength, and improving their hunting skills, but even the smallest cats in our sample had tackled and consumed large and potentially ‘dangerous’ prey that would likely have put up a defence