Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

Open Access via Springer Compact Agreement Acknowledgements We are very grateful to Prof. Calderwood (Yale University, USA) for providing the THD DNA construct, Dr. Massimiliano Baldassarre (University of Aberdeen) for useful discussions on integrin regulation and Charlie Taylor for helping to optimise the THD transfection experiments. We thank the NHS Grampian Endowment Fund for funding this research and CRANES and the Roland Sutton Academic Trust for financial support for AA.Peer reviewedPublisher PD

KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Peer reviewedPublisher PD

The RUMERTIME Process as a Protective Factor in School Attendance Problems

The RUMERTIME Process (RP) is a five-step culturally responsive social-emotional, problem-solving, prevention-intervention strategy used to educate, equip, and empower students, educators, and families. The RP equips individuals with the abilities to recognize, understand, manage, express, and reflect on their thoughts, interactions, mindsets, and emotions (RUMERTIME) in relation to themselves, others, and the daily life challenges they face within multiple systems and settings. The RP is embedded within the Cultivating SEEDS System framework (CSS) and is utilized to equip culturally diverse communities, inclusive of students, family members, educators, and administrators, with the social-emotional skills to effectively solve student attendance problems (SAPs). The data shared in this practice intervention article are descriptive in nature and highlight the RP as a protective factor and explain its three goals. The paper consists of three parts: (a) introduction of the RP, which is embedded in the CSS framework; (b) description of implementation of the RP as integral to the Daytime Intervention Room (DIR) program; and (c) discussion of risk factors that qualified students to receive services through the DIR program as well as data that demonstrated how the RP performed as a protective factor. The DIR program was aimed at creating an alternative to out-of-school suspension (OSS) and the traditional punitive in-school suspension (ISS). The program was established in each of the four schools in an urban high-needs school district in the midwest region of the United States. The DIR program was intentionally designed to include multiple levels, stakeholders, and delivery support, thus creating a solid base for the holistic development of students, educators, and parents. In conjunction with the CSS framework, the DIR program sought to increase academic performance, decrease the number of behavior referrals, and improve attendance rates in this high-needs urban school district

Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

We thank the Development Trust, University of Aberdeen, for funding a fellowship to M.P. and a studentship to A.A. Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590898.Peer reviewedPostprin

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

We thank the Engineering and Physical Sciences Research Council, UK, for a research grant (EP/M01262X/1).Peer reviewedPostprin

The psychological predictors of acute and chronic pain in women following breast cancer surgery : a systematic review

Objectives: Numerous psychological factors have been found to be associated with acute and chronic pain following breast cancer surgery. However, individual studies tend to be limited to a small number of predictors and many fail to employ prospective designs. This study aimed to identify a broader range of psychological predictors of acute and chronic pain following breast cancer surgery through a systematic review of relevant prospective studies. Methods: Web of Science, psychINFO, PubMed, and MEDLINE databases were searched to identify relevant prospective cohort studies. Studies were included if women were to undergo mastectomy or wide local excision, if psychological factors were assessed before surgery, and pain assessed after surgery. Results: Twelve studies (representing 11 independent cohorts) met the inclusion criteria and described 10 psychological predictors. Anxiety and depression were the most frequently assessed psychological factors, and were measured in nine of the 12 studies. Anxiety and psychological robustness emerged as significant predictors of acute pain. Distress was the strongest predictor of chronic pain. The relationship between depression and chronic post-surgical pain was, at best, mixed. Discussion: This review has identified a range of psychological predictors of acute and chronic pain following breast cancer surgery, however the evidence was conflicting and limited. Future studies should demonstrate adequate power and take account of known confounders

Northeast Conference on Andean Archaeology and Ethnohistory (NCAAE) Statement on Sexual harassment and Community Values

This is a statement on sexual harassment and community values signed by eight members of the Northeast Conference on Andean Archaeology and Ethnohistory (NCAAE)https://digitalcommons.library.umaine.edu/andean_past_special/1008/thumbnail.jp

Morphological consequences of hybridization between farm and wild Atlantic salmon Salmo salar under both wild and experimental conditions

The escape of Atlantic salmon Salmo salar from aquaculture has been identified as a significant threat to the persistence and stability of wild salmon populations. Yet the magnitude of phenotypic impacts due to hybridization remains largely unresolved. We evaluated the phenotypic consequences of hybridization using geometric morphometrics both under natural conditions in the wild and in the laboratory using common garden experiments. Juvenile Atlantic salmon field-collected in 2015 and 2016 from 18 southern Newfoundland rivers were classified as pure wild, pure farm, or F1 hybrids using genetic assignment. Overall size and shape differences between wild and farm, and wild and F1 hybrid individuals were small, largely size related, and present between pure farm and other crosses. Laboratory-reared pure wild, pure farm, and F1 hybrid salmon were grown in tank and semi-natural conditions. Wild fish were significantly larger than both farm and hybrid salmon at first feeding; these size differences remained at 80 d post first feeding under semi-natural conditions, but all crosses were the same size in tank conditions, and there were no differences between pure farm and hybrid individuals under either condition. Significant shape differences were present among all pairwise comparisons under tank conditions, and in semi-natural conditions, pure wild individuals differed significantly from pure farm and hybrid individuals. Our results suggest phenotypic differences observed under laboratory conditions between wild and farm×wild hybrid individuals may not be appreciable in the wild, and that significant genetic changes may occur in wild populations experiencing hybridization in the absence of obvious large phenotypic changes.publishedVersio

NGR Tumor-Homing Peptides : Structural Requirements for Effective APN (CD13) Targeting

Acknowledgements We thank The Development Trust, University of Aberdeen, for financial support and a fellowship to M.P.Peer reviewedPublisher PD