The Case for a Low Extragalactic Gamma-ray Background

Measurements of the diffuse extragalactic gamma-ray background (EGRB) are complicated by a strong Galactic foreground. Estimates of the EGRB flux and spectrum, obtained by modeling the Galactic emission, have produced a variety of (sometimes conflicting) results. The latest analysis of the EGRET data found an isotropic flux I_x=1.45+-0.05 above 100 MeV, in units of 10^-5 s^-1 cm^-2 sr^-1. We analyze the EGRET data in search for robust constraints on the EGRB flux, finding the gamma-ray sky strongly dominated by Galactic foreground even at high latitudes, with no conclusive evidence for an additional isotropic component. The gamma-ray intensity measured towards the Galactic poles is similar to or lower than previous estimates of I_x. The high latitude profile of the gamma-ray data is disk-like for 40<|b[deg]|<70, and even steeper for |b|>70; overall it exhibits strong Galactic features and is well fit by a simple Galactic model. Based on the |b|>40 data we find that I_x<0.5 at a 99% confidence level, with evidence for a much lower flux. We show that correlations with Galactic tracers, previously used to identify the Galactic foreground and estimate I_x, are not satisfactory; the results depend on the tracers used and on the part of the sky examined, because the Galactic emission is not linear in the Galactic tracers and exhibits spectral variations across the sky. The low EGRB flux favored by our analysis places stringent limits on extragalactic scenarios involving gamma-ray emission, such as radiation from blazars, intergalactic shocks and production of ultra-high energy cosmic rays and neutrinos. We suggest methods by which future gamma-ray missions such as GLAST and AGILE could indirectly identify the EGRB.Comment: Accepted for publication in JCAP. Increased sizes of polar regions examined, and added discussion of spectral data. Results unchange

Observing the Sun with the Atacama Large Millimeter-submillimeter Array (ALMA): Fast-Scan Single-Dish Mapping

The Atacama Large Millimeter-submillimeter Array (ALMA) radio telescope has commenced science observations of the Sun starting in late 2016. Since the Sun is much larger than the field of view of individual ALMA dishes, the ALMA interferometer is unable to measure the background level of solar emission when observing the solar disk. The absolute temperature scale is a critical measurement for much of ALMA solar science, including the understanding of energy transfer through the solar atmosphere, the properties of prominences, and the study of shock heating in the chromosphere. In order to provide an absolute temperature scale, ALMA solar observing will take advantage of the remarkable fast-scanning capabilities of the ALMA 12m dishes to make single-dish maps of the full Sun. This article reports on the results of an extensive commissioning effort to optimize the mapping procedure, and it describes the nature of the resulting data. Amplitude calibration is discussed in detail: a path that utilizes the two loads in the ALMA calibration system as well as sky measurements is described and applied to commissioning data. Inspection of a large number of single-dish datasets shows significant variation in the resulting temperatures, and based on the temperature distributions we derive quiet-Sun values at disk center of 7300 K at lambda=3 mm and 5900 K at lambda=1.3 mm. These values have statistical uncertainties of order 100 K, but systematic uncertainties in the temperature scale that may be significantly larger. Example images are presented from two periods with very different levels of solar activity. At a resolution of order 25 arcsec, the 1.3 mm wavelength images show temperatures on the disk that vary over about a 2000 K range.Comment: Solar Physics, accepted: 24 pages, 13 figure

Imprint of Intergalactic Shocks on the Radio Sky

Strong intergalactic shocks are a natural consequence of structure formation in the universe. They are expected to deposit large fractions of their energy in relativistic electrons (xi_e~0.05 according to SNR observations) and magnetic fields (xi_B~0.01 according to cluster halo observations). We calculate the synchrotron emission from such shocks using an analytical model, calibrated with a hydrodynamical LCDM simulation. The resulting signal composes a large fraction of the extragalactic radio background (ERB) below 500 MHz. The associated angular fluctuations dominate the sky for frequencies nu<10 GHz and angular scales arcmin-deg (after a modest removal of point sources), provided that xi_e*xi_B>3*10^-4. The fluctuating signal is most pronounced for nu<500 MHz, dominating the sky even for xi_e*xi_B=5*10^-5. The signal will be easily observable by next generation radio telescopes such as LOFAR and SKA, and is marginally observable with present telescopes. It may be identified using cross-correlations with tracers of large scale structure, possibly even in existing <10 GHz CMB anisotropy maps and high resolution ~1 GHz radio surveys. Detection of the signal will provide the first identification of intergalactic shocks and of the WHIM, and gauge the unknown intergalactic magnetic field. We show that existing observations of the diffuse <500 MHz radio background are well fit by a simple, double-disk Galactic model, precluding a direct identification of the diffuse ERB. Modelling the frequency-dependent anisotropy pattern observed at very low (1-10 MHz) frequencies can disentangle the distributions of Galactic cosmic-rays, ionized gas and magnetic fields. Space missions such as ALFA will thus provide important insight into the structure and composition of our Galaxy (abridged).Comment: Accepted for publication in ApJ. Presentation improved and references adde

Inhibiting the Inflammasome: A Chemical Perspective

Inflammasomes are high molecular weight complexes that sense and react to injury and infection. Their activation induces caspase-1 activation and release of interleukin-1β, a pro-inflammatory cytokine involved in both acute and chronic inflammatory responses. There is increasing evidence that inflammasomes, particularly the NLRP3 inflammasome, act as guardians against noninfectious material. Inappropriate activation of the NLRP3 inflammasome contributes to the progression of many noncommunicable diseases such as gout, type II diabetes, and Alzheimer’s disease. Inhibiting the inflammasome may significantly reduce damaging inflammation and is therefore regarded as a therapeutic target. Currently approved inhibitors of interleukin-1β are rilonacept, canakinumab, and anakinra. However, these proteins do not possess ideal pharmacokinetic properties and are unlikely to easily cross the blood–brain barrier. Because inflammation can contribute to neurological disorders, this review focuses on the development of small-molecule inhibitors of the NLRP3 inflammasome